Breast cancer in people assigned male at birth is rare, but it can grow and spread like any other cancer if left untreated. We offer precise diagnostic testing for men at Penn Medicine. Our Breast Cancer Program specialists pinpoint the characteristics of male breast cancer and provide personalized, effective treatment.
What is male breast cancer?
Male breast cancer is when there is abnormal cell growth in the breast cells of people assigned male at birth. Though it is rare, men can get breast cancer. Just like women, men have breast tissue that can develop cancer. Most breast cancer in men is ductal carcinoma, which means the cancer cells began growing in the (milk) ducts of the breast but can also begin in the glands (lobular cancer), even though these breast parts are not functional in men.
The risk factors for breast cancer in men are similar to other types of breast cancer. According to the American Cancer Society, breast cancer is about 100 times less common in men than it is in women. Male breast cancer can occur at any age, but typically develops in men between the ages of 60 and 70. Additional conditions that increase risk factors for men include:
- Obesity
- Undescended testicle
- Testicular swelling, due to adult-onset mumps
- Removal of one or more testicles
- Estrogen treatment, given as hormone therapy for men with prostate cancer
- Having a BRCA1 or BRCA2 genetic mutation (both genders can have a BRCA mutation).
Male breast cancer symptoms
People who are assigned male at birth are not screened for breast cancer, so any changes to your breast should be checked by a doctor. While some men may have no symptoms, the first sign of male breast cancer is usually a lump that feels like a hard knot. Others may exhibit the more common symptoms of breast cancer.
Without regular screening for male breast cancer, symptoms may be the first warning of a possible breast cancer diagnosis. See or contact your doctor immediately if you notice any of the following:
- Mass or lump in the breast
- Nipple discharge (may be bloody)
- Nipple retraction (turning inward)
- Skin ulcers (open sores) on the breast
Male breast cancer diagnosis
If breast cancer is suspected, we use breast imaging and breast biopsy to diagnose male breast cancer. Your care team will check your lymph nodes to determine the stage of cancer during your breast cancer diagnosis.
Types of breast cancer in men
Identifying the type of breast cancer helps us determine the most effective treatment. Men can be diagnosed with several different types of breast cancer, including:
- Ductal carcinoma in situ (DCIS), considered early-stage male breast cancer
- Inflammatory breast cancer (IBC), where the first sign is a red, swollen, and warm breast
- Invasive ductal carcinoma (IDC), which accounts for 80 percent of male breast cancers
- Paget’s disease of the nipple, when a tumor grows from the ducts beneath the nipple
A pathologist studies breast cancer tissue to identify hormone receptor status, which will determine the presence or absence of excess progesterone and estrogen receptors, as well as HER2 status. This will affect the treatment plan.
Treatment for breast cancer in men
We personalize breast cancer treatment according to a tumor’s type, stage, and receptor status. Our specialized providers collaborate to create a treatment plan that is advanced and effective.
If pathologists are able to identify ER+/PR+ hormone receptors and human epidermal growth factor receptor 2 (HER2), this will affect the treatment plan. About 90 percent of male breast cancers are hormone receptor-positive and treatable with hormone therapy. If cancer is HER2-positive, we treat it with targeted therapy.
Other possible treatments for male breast cancer include one or a combination of other options.
Why choose Penn Medicine for male breast cancer?
We offer comprehensive breast cancer care for all types and stages of male breast cancer. At Penn Medicine, you’ll find:
- Advanced imaging: Our specialized radiologists use leading-edge imaging technology to diagnose breast cancer in men. Our quick and accurate diagnosis ensures you get personalized treatment as soon as possible.
- Leaders in targeted therapy: We use our experience and expertise in targeted therapy to deliver advanced breast cancer treatment based on tumor characteristics.
- Access to innovative care: Through our diverse portfolio of breast cancer research and clinical trials, you have access to new and promising treatments for male breast cancer.
- Care where you live: All Penn Medicine breast cancer locations provide expert breast cancer diagnosis, testing, and treatment. Specialists across the network work together seamlessly to get you the care you need when and where you need it.
- Genetic cancer research: In some cases, male breast cancer can be linked to a BRCA genetic mutation. Penn Medicine’s Basser Center for BRCA has helped accelerate progress for BRCA-related cancer research and therapies.
Rated “exceptional” by The National Cancer Institute
Penn Medicine’s Abramson Cancer Center is a world leader in cancer research, patient care, and education. Our status as a national leader in cancer care is reflected in our continuous designation as a Comprehensive Cancer Center by the National Cancer Institute (NCI) since 1973, one of 7 such centers in the United States. The ACC is also a member of the National Comprehensive Cancer Network, one of a select few cancer centers in the U.S., that are working to promote equitable access to high-quality, advanced cancer care.