Neuroscience and cancer innovations that are redefining the future are a major focus of this issue. The cover story highlights the new, brain-powered Pavilion at the Hospital of the University of Pennsylvania, where cutting-edge neuroscience work will transform research and clinical care. Other stories highlight cancer, from a look back on the half-century career of Penn’s longest-serving cancer center director, to cancer outreach in our communities, and a creative cancer patient helping others through art.