Gastric (stomach) cancer

Gastric cancer, also known as stomach cancer, starts in the lining of the stomach. The stomach is a muscular, sac-like organ in the upper abdomen, just below the ribs. It plays a central role in digesting food.

Most stomach cancers are adenocarcinomas, a type of cancer that develops in the inner layer of the stomach. Less common types include:

• Lymphomas: These cancers begin in the immune system cells found in the stomach wall.
• Gastrointestinal stromal tumors (GISTs): This type can develop along any part of the digestive tract, but commonly occurs in the stomach wall cells.
• Neuroendocrine tumors (NETs): Also called carcinoid tumors, these tumors originate from the hormone-producing cells of the stomach and begin in the digestive tract.

Managing stomach cancer requires exceptional skill and expertise. We have highly trained surgeons who excel in removing challenging stomach tumors. In addition, our cancer specialists—gastroenterologists, radiologists, and pathologists—work together to develop customized treatment plans and support services tailored to your specific needs.

Stomach cancer symptoms

Gastric cancer usually doesn’t present noticeable symptoms in its early stages. When symptoms do appear, they may include:

• Indigestion or heartburn
• Difficulty swallowing
• Loss of appetite
• Abdominal pain or discomfort
• Nausea and vomiting
• Fatigue
• Unintended weight loss
• Feeling full after eating small amounts of food
• Blood in the stool

What causes stomach cancer

The exact cause of stomach cancer isn’t fully understood, but experts believe that damage to the stomach lining, such as from infections or acid reflux, can lead to changes in the cells. These changes can cause the cells to grow uncontrollably, forming a tumor.

A small portion of stomach cancers have a genetic link, caused by a problem in the CDH1 gene. People with a CDH1 genetic mutation have a greater chance of developing hereditary diffuse gastric cancer (HDGC). Penn Medicine specialists offer unique expertise in treating CDH1 mutation and stomach cancer risk.

Stomach cancer diagnosis at Penn Medicine

An accurate diagnosis from trusted cancer specialists is essential for creating individualized treatment plans for stomach cancer. Our team uses advanced diagnostic tools to enhance the detection and treatment of gastric cancer.

Stomach cancer treatment at Penn Medicine

Successfully treating stomach cancer requires specialized expertise and training. Treatment options can include surgery, chemotherapy, immunotherapy, radiation, and other therapies. Our team of specialists stays updated with the latest research to develop a treatment plan tailored to achieve the best possible outcome for you.

Exceptional expertise in stomach cancer care

Penn Medicine doctors receive extensive training that provides them with deep expertise in treating rare and complex stomach cancers. A multidisciplinary team, including oncologists and pathologists, collaborates on every patient’s care, ensuring thorough and well-rounded treatment.

Our surgeons perform a high volume of successful gastrectomy (stomach removal) surgeries to treat stomach cancer. In many cases, thoracic surgeons, surgical oncologists, and gastrointestinal surgeons work together, performing specialized procedures. This team approach enables us to make sure you get the best treatment.

Also, you’ll have the support of a nurse navigator, who will help schedule appointments and provide necessary support. We offer a range of resources, including counseling and meditation classes, to help you maintain your well-being throughout your stomach cancer journey.