News Releases

"A biologist, a physicist, and a nanotechnologist walk into a ..." sounds like the start of a joke. Instead, it was the start of a collaboration that has helped to decipher a critical, but so far largely unstudied, phase of how cells divide. Errors in cell division can cause mutations that lead to cancer, and this study could shed light on the role of chromosome abnormalities in uncontrolled cell replication.

Far away from town hall showdowns on the future of health care in America, the next generation of doctors is preparing to don their first white coats, a sign of commitment and optimism as they begin learning the art and science of healing. The 161 individuals in the University of Pennsylvania School of Medicine's entering class of 2009 will recite the time honored Hippocratic Oath to "first, do no harm" in front of family and friends on Friday, August 14, as they start their medical careers. Ranging from 21 to 28 years in age, students in the class represent 61 colleges and 31 states from around the country - nearly one quarter are from Pennsylvania. However the health care reform debate is resolved, these men and women stand ready to follow in the Penn Medicine tradition of compassionate care, advanced medicine and putting patients first.

One year after a trio of young adults received gene therapy for an inherited form of blindness, researchers have documented that the patients are still experiencing the same level of remarkable vision improvements previously measured within weeks. This is the first study to report one-year gene therapy safety and efficacy results in treating young adults with Leber Congenital Amaurosis (LCA), a hereditary condition that causes severe vision impairment in infants and children. The findings are published in Human Gene Therapy, now online, and in the New England Journal of Medicine (NEJM) this week.

Findings Pave Way for New Recommendations to Nation’s 2.4 Million Breast Cancer Survivors

Molecules capable of blocking the formation of specific protein clumps that are believed to contribute to the dementia of Alzheimer's disease patients has been discovered by researchers

Fibrin, the chief ingredient of blood clots, is a remarkably versatile polymer. On one hand, it forms a network of fibers -- a blood clot -- that stems the loss of blood at an injury site while remaining pliable and flexible. On the other hand, fibrin provides a scaffold for thrombi, clots that block blood vessels and cause tissue damage, leading to myocardial infarction, ischemic stroke, and other cardiovascular diseases. How does fibrin manage to be so strong and yet so extensible under the stresses of healing and blood flow?

A brain-preserving cooling treatment called therapeutic hypothermia is a cost-effective way to improve outcomes after out-of-hospital cardiac arrest, which claims the lives of more than 300,000 people each year in the United States and leaves thousands of others neurologically devastated. The treatment, which lowers body temperature to prevent damage to the brain and other major organs when blood flow is restored to the body following cardiac arrest, is considered a "good value" when compared to many other accepted and widely utilized medical treatments, including dialysis for kidney failure or complex heart surgeries, according to new University of Pennsylvania School of Medicine research published this week in Circulation: Cardiovascular Quality and Outcomes.

In a post-recession America, even though as a nation income levels may rise, middle class families still won't be shielded from the crushing burden of health care costs and will watch their standards of living continue to erode, according to a study published this week in the New England Journal of Medicine (NEJM) by Daniel Polsky, Ph.D., and David Grande, M.D., M.P.A, of the University of Pennsylvania's Leonard Davis Institute of Health Economics.

The accepted dogma has been that bone-forming cells, derived from the body's connective tissue, are the only cells able to form the skeleton. However, new research shows that specialized cells in the blood share a common origin with white blood cells derived from the bone marrow and that these bloodstream cells are capable of forming bone at sites distant from the original skeleton. This work, published online this month in the journal Stem Cells, represents the first example of how circulating cells may contribute to abnormal bone formation.

Thomas Cappola, MD, ScM, an assistant professor in the division of Cardiovascular Medicine at the University of Pennsylvania School of Medicine, has been honored with a Presidential Early Career Award for Scientists and Engineers. The award, the highest honor bestowed by the U.S. government on outstanding early-career scientists and engineers, recognizes Cappola's outstanding achievements in research on causes and treatment for heart failure, which is the leading cause of hospitalization among adults in the United States.