News Releases

Using CRISPR gene editing, a team from Penn Medicine and Children’s Hospital of Philadelphia (CHOP) have thwarted a lethal lung disease, in an animal model, in which a harmful mutation causes death within hours after birth.

Researchers from the Perelman School of Medicine at the University of Pennsylvania have shown, in mice, that one type of stem cell that makes adult neurons is the source of this lifetime stock of new cells in the hippocampus.

The Gene Therapy Program Preclinical Vector Core in the Perelman School of Medicine at the University of Pennsylvania has been awarded a Gene Therapy Resource Program (GTRP) contract for a third consecutive five-year period from the National Heart, Lung and Blood Institute (NHLBI) of the National Institutes of Health (NIH).

Penn Medicine research team participates in international consortium on Alzheimer’s genetics

Drugs called thiazolidinediones (TZDs) reverse insulin resistance in patients with type 2 diabetes by targeting the activity of a receptor protein. However, an array of side effects, including weight gain, edema, and high cholesterol, limits their use in the clinic.

In a paper published this week in Science, researchers from the Perelman School of Medicine at the University of Pennsylvania found that in mouse embryos--only eight days after fertilization--compacted regions along the genome increase at protein-coding genes.

New stem-cell-based test aims to decrease uncertainty of gene variants with unclear health significance

A twist on the molecular mechanism of how a new cancer drug works could aid in better identifying the best treatments for patients for an array of cancers.