Description of Research Expertise
Thormbosis, fibrinolysis, vascular biology, immunohematology
Selected Publications
Sarkar A, Yadav SK, Field CO, Gollomp K, McCrae KM, Ortel T, Gruel Y, Rollen J, Arepally GM, Rauova L, Cines DB, Poncz M.: Anti-phospholipid syndrome (APS) antibody (Ab)-induced thrombosis can be blocked by platelet factor 4 (PF4)-directed Abs: A novel therapeutic for APS? ASH : 2024.
Myoung S, Francis SJ, Chen J, Lee G, Rauova L, Poncz M, Cines DB, Kuchibhatla M, Khandelwal S, Arepally GM.: Complement Activation as a biomarker for platelet activating HIT antibodies. ASH 2024. ASH : 2024.
Field CO, Sarkar A, Bdeir Kh, McRae KR, Ortel TL, Kowalska MA, Rauova L, Cines DB, Gollomp K, Poncz M.: Antiphospholipid syndrome (APS) is a platelet factor 4 (PF4)-centric immunothrombotic disorder. ASH : 2024.
Rauova L, Oberg J, Gilbert S, Cines DB, Poncz M.: A murine model of vaccine-induced immune thrombotic thrombocytopenia (VITT) leads to anti-NAP2 and anti-PF4 antibodies and may involve TLR9 activation. ISTH : 2024.
Ngo ATP, Skidmore A, Yarovoi I, Sarkar A, Levine ND, Bochenek V, Zhao G, Rauova L, Kowalska MA, Eckart K, Mangalmurti NS, Rux A, Cines DB, Poncz M, Gollomp K.: Platelet factor 4 limits neutrophil extracellular trap- and cell-free DNA-induced thrombogenicity and endothelial injury. JCI-Insight. 8 (22): 2023.
Bussel JM, Hou M, Cines DB.: Management of primary ITP in pregnancy. New Eng J Med. 389 (6): 540,2023.
Sarkar A, Khandelwal S, Koma G, Kim H, Gruel Y, Rollin J, Passam FH, Wool GD, Arepally GM, Cines DB, Rauova L, Poncz M.: Prevention of thrombocytopenia and thrombosis in HIT using deglycosylated KKO: a novel therapeutic? Blood Adv : 2023.
Cines DB, Greinacher A.: Vaccine-induced immune thrombotic thrombocytopenia Blood 141 : 1659-1665,2023.
Cai Z, Bdeir K, Yarovoi SV, Rauova L, Arepally GM, Khandelwal S, Rollin J, Gruel Y, Zaitsev S, Poncz M, Greene MI, Cines DB.: Modulation of ultralarge immune complexes in heparin-induced thrombocytopenia J Thromb Haemost : 2023.
Rauova L, Oberg J, Field C, Levine N, Arepally HM, Cines DB, Cohen T, Poncz M: ChadOx exposure-induced neutrophil-activating peptide 2 (NAP2) antibodies: Murine-based insights into the pathgenesis of vaccine-induced immune thrombotic thrombocytopenia (VITT). ISTH : 2023.
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Academic Contact Information
Dept. Pathology and Laboratory Medicine
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania
Philadelphia,
PA
19104
Phone: 215-662-3966
Patient appointments: 800-789-7366