Description of Research Expertise

An extension of Dr. Weinstein's special interest in organ preservation surgery has been clinical research in the area of Transoral Robotic Surgery (TORS) He is Principal investigator of the first IRB approved human clinical trial for robotic surgery in the field of Head and Neck Surgery. As co-founder of the first in the world research program in human TORS, he has been involved with clinical research in both developing new techniques, instrumentation, as well as adaptation of laser technology to robotic surgery. Dr. Weinstein has also been involved in establishing the first training program in TORS. Dr. Weinstein has trained physician/researchers from a number of centers around the United States in the TORS techniques and has had trained visiting surgeons in the TORS techniques from Japan, Korea, China, Australia, Sweden, Brazil, France, India as well as others. He has authored numerous articles in the area of robotic surgery and is on the editorial board of the Journal of Robotic Surgery and is a founding Board Member and First President of the SRS(Society for Robotic Society).

Recent Peer Reviewed Articles ( For Complete List See below)

1. Chawla S, Kim S, Loevner LA, Quon H, Wang S, Mutale F, Weinstein G, Delikatny EJ, Poptani H.: Proton and phosphorous MR spectroscopy in squamous cell carcinomas of the head and neck. Acad Radiol 16(11): 1366-72, Nov 2009.

2. Chawla S, Kim S, Loevner LA, Quon H, Wang S, Mutale F, Weinstein G, Delikatny EJ, Poptani H.: Proton and phosphorous MR spectroscopy in squamous cell carcinomas of the head and neck. Acad Radiol 16(11): 1366-72, Nov 2009.

3. Lee JY, O'Malley BW, Newman JG, Weinstein GS, Lega B, Diaz J, Grady MS.: Transoral robotic surgery of craniocervical junction and atlantoaxial spine: a cadaveric study. J Neurosurg Spine 12(1): 13-8, Jan 2010.

4. Bar Ad V, Weinstein G, Dutta PR, Chalian A, Both S, Quon H.: Gabapentin for the treatment of pain related to radiation-induced mucositis, in patients with head and neck tumors treated with intensity modulated radiation therapy (IMRT) Head and Neck Journal 32(2): 173-7, Feb 2010.

5. Kim S, Loevner LA, Quon H, Kilger A, Sherman E, Weinstein G, Chalian A, Poptani H.: Prediction of response to chemoradiation therapy in squamous cell carcinomas of the head and neck using dynamic contrast-enhanced MR imaging. AJNR Am J Neuroradiol 31(2): 262-8, Feb 2010.

6. Selber JC, Robb G, Serletti JM, Weinstein G, Weber R, Holsinger FC.: Transoral robotic free flap reconstruction of oropharyngeal defects: a preclinical investigation. Plast Reconstr Surg. 2010 Mar;125(3):896-900 125(3): 896-900, Mar 2010.

7. Selber JC, Robb G, Serletti JM, Weinstein G, Weber R, Holsinger FC.: Transoral robotic free flap reconstruction of oropharyngeal defects: a preclinical investigation. Plast Reconstr Surg 125(3): 896-900, Mar 2010.

8. Lee JY, Lega B, Bhowmick D, Newman JG, O'Malley BW Jr, Weinstein GS, Grady MS, Welch WC.: Da Vinci Robot-Assisted Transoral Odontoidectomy for Basilar Invagination. ORL J Otorhinolaryngol Relat Spec 72(2): 91-95, May 2010.

9. Basu D, Nguyen TT, Montone KT, Zhang G, Wang LP, Diehl JA, Rustgi AK, Lee JT, Weinstein GS, Herlyn M.: Evidence for mesenchymal-like sub-populations within squamous cell carcinomas possessing chemoresistance and phenotypic plasticity. Oncogene 29(29): 4170-82, Jul 2010

10. Atkins, JH, Mandel, JE, Weinstein, GS, Mirza, N: A Pilot Study of Respiratory Inductance Plethysmography as a Safe, Noninvasive Detector of Jet Ventilation Under General Anesthesia Anesth Analg epub ahead of print, Aug 2010.

11. Grossman C, Zhu T, Finlay J, Dimofte A, Malloy K, O'Malley B Jr, Weinstein G, Busch TM, Quon H.: Targeted laryngeal photodynamic therapy with a balloon diffusing light source. Photodiagnosis Photodyn Ther 7(3): 158-161, Sep 2010

12. Weinstein GS, Quon H, O'Malley Jr. BW, Kim GG, Cohen MA. : Selective neck dissection and de-intensified postoperative radiation and chemotherapy for Oropharyngeal Cancer: A Subset Analysis of the University of Pennsylvania TORS Trial Laryngoscope 120(9): 1749-55, Sep 2010.

13. Benito J, Holsinger FC, Pérez-Martín A, Garcia D, Weinstein GS, Laccourreye O.: Aspiration after supracricoid partial laryngectomy: Incidence, risk factors, management, and outcomes. Head Neck Page: In press. 2010.

14. Lee JYK, O'Malley, BW, Newman, JG, Weinstein, GS, Lega, B, Diaz, J, Grady, MS: Transoral Robotic Surgery of the SkullBase: A Cadaver and Feasibility Study. ORL J Otorhinolaryngol Relat Spec. 2010;72(4):181-7. 72(4): 181-7, 2010.

15. O'Malley, BW Jr, Quon, H, Weinstein, GS : TransOral Robotic Surgery (TORS) for Parapharyngeal Space Tumors ORL Otorhino and Related Spec In press, 2010.

16. Quon, H, O'Malley, BW, Jr. Weinstein, GS: Postoperative Adjuvant Therapy Following TransOral Robotic Resection (TORS) for Oropharyngeal Carcinomas: rationale and current treatment approach. ORL Page: In press, 2010

17. Cohen MA , Weinstein GS, O'Malley Jr. BW, Feldman M, and Quon H. : Transoral Robotic Surgery (TORS) and Human Papillomavirus (HPV) Status: Oncologic Results. Head and Neck Surgery in press.

18. Weinstein GS, O'Malley Jr. BW, Cohen MA, and Quon H. : Transoral Robotic Surgery(TORS) for Advanced Oropharyngeal Carcinoma. The Archives of Otolaryngology: Head and Neck Surgery in press.



Editorials, Reviews, Chapters, including participation in committee reports (print or other media):
1. Laccourreye, O., Weinstein, G.S., Brasnu, D. and Laccourreye, H.: Editorial response on "A clinical trial of continuous cisplatin-fluorouracil induction chemotherapy and supracricoid partial laryngectomy with cricohyoidoepiglottopexy for glottic cancer staged as T2." Cancer 76: 149-151, 1995.

2. Weinstein, G.S., Laccourreye, O. and Yousem, D. : The role of CT and MR planning in conservation laryngeal surgery. The Neuroimaging Clinics of North America. Yousem, D. (eds.). May 1996.

3. Brasnu, D., Weinstein, G.S., Laccourreye, O.: Supracricoid partial laryngectomies for endolaryngeal carcinoma: oncological and functional indications and results. , In Proceedings of the Fourth International Conference on Head and Neck Cancer, Toronto, July 28 - August 1, 1996, Shah, J.P. and Johnson, J.T. (eds.). The Society of Head and Neck Surgeons, Arlington, Virginia. 1996.

4. Rassekh, C , Weinstein, G.S. and Laccourreye, O.: Supracricoid laryngectomy with cricohyoidopexy. Otolaryngology - Head and Neck Surgery. Bailey, B. et al (eds.). Lippincott - Raven 1998.

5. Weinstein, G.S.: Conservation laryngeal surgery. Renewal of Certification Study Guide in Otolaryngology Head and Neck Surgery, Gluckman, J. (eds.). Kendall/Hunt Publishing Company, Dubuque, Iowa, 1998.

6. Weinstein, G.S.: Malignant neoplasms of the salivary glands. Renewal of Certification Study Guide in Otolaryngology Head and Neck Surgery. Gluckman, J. (eds.). Kendall/Hunt Publishing Company, Dubuque, Iowa 1998.

7. Weinstein, G.S. and Laccourreye, O.: Supracricoid Partial Laryngectomy. Advances in Head and Neck Oncology, Robbins, K.T., Editor. Singular Publishing Group, Inc., San Diego, California, 1998. Robbins, K.T. (eds.). Singular Publishing Group, Inc., San Diego, California, 1998.

8. Weinstein, G.S., Laccourreye, O. and Rassekh, C.: Conservation laryngeal surgery. Otolaryngology - Head and Neck Surgery. Cummings, C., et al. (eds.). W.B. Saunders, Philadelphia, Pennsylvania, 1998.

9. Laccourreye O., Weinstein, G.S. : Cirurgia de los tumores gloticos y subgloticos Tratado de Otorrinolaringologica y Cirugia de Cabeza Y Cuello Suiarez, C., Medina, J. (eds.). Poyectos Medicos Guadalajara, 1999.

10. Laccourreye, H., Laccourreye, O.,Weinstein, G.S.: Preoperative Evaluation for Organ Preservation Surgery of the Larynx. Organ Preservation Surgery for Laryngeal Cancer. Weinstein, G.S., Laccourreye, O., Brasnu, D., Laccourreye, H. (eds.). Singular Publishing Group, San Diego, California, 2000.

11. Laccourreye, O., Laccourreye, H., El-Sawy, M., Weinstein, G.S. : Supracricoid Partial Laryngectomy with Cricohyoidoepiglottopexy. Organ Preservation Surgery for Laryngeal Cancer. Weinstein, G.S., Laccourreye, O., Brasnu, D., Laccourreye, H. (eds.). Singular Publishing Group, San Diego, California, 2000.

12. Laccourreye, O., Weinstein, G.S.: Supraglottic Laryngectomy. Organ Preservation Surgery for Laryngeal Cancer. Weinstein, G.S., Laccourreye, O., Brasnu, D., Laccourreye, H. (eds.). Singular Publishing Group, San Diego, California, 2000.

13. Weinstein, G., Anderson, T.: Commentary on exuberant nasal polyposis. Resident and Staff Physician 46: 37-44, 2000.

14. Weinstein, G.S., Brasnu, D., Laccourreye, H.: Laryngeal Anatomy: Surgical and Clinical Implications. Organ Preservation Surgery for Laryngeal Cancer. Weinstein, G.S., Laccourreye, O., Brasnu, D., Laccourreye, H. (eds.). Singular Publishing Group, San Diego, California, 2000.

15. Weinstein, G.S., Laccourreye, O.: Organ Preservation Surgery of the Larynx: A New Paradigm. Organ Preservation Surgery for Laryngeal Cancer. Weinstein, G.S., Laccourreye, O., Brasnu, D., Laccourreye, H. (eds.). Singular Publishing Group, San Diego, California. 2000.

16. Weinstein, G.S., Laccourreye, O. : Vertical Partial Laryngectomies. Organ Preservation Surgery for Laryngeal Cancer. Weinstein, G.S., Laccourreye, O., Brasnu, D., Laccourreye, H. (eds.). Singular Publishing Group, San Diego, California 2000.

17. Weinstein, G.S., Laccourreye, O., Muscatello, L. : Optimizing Postsurgical Clinical Outcome. Organ Preservation Surgery for Laryngeal Cancer. Weinstein, G.S., Laccourreye, O., Brasnu, D., Laccourreye, H. (eds.). Singular Publishing Group, San Diego, California, 2000.

18. Weinstein, G.S., Harvey, R. : Open Surgical Resection of Sinus Neoplasms. Diseases of the Sinuses: Diagnosis and Endoscopic Management. Kennedy, D., Zinreich, S.J., Bolger, W, (eds.). B.C. Decker, Inc., Hamilton, Ontario, Canada, 2001.

19. Weinstein, G.S. : Partial Laryngeal Procedures. Head and Neck Cancers. Ensly, J.F., Lippman, S.M., Jacobs, J.R., Gutkind, J.S. (eds.). Academic Press, 2002.

20. Tufano, R., Weinstein, G.S., Laccourreye, O. and Rassekh, C.: Conservation laryngeal surgery. Otolaryngology - Head and Neck Surgery. Cummings, C., et al. (eds.). W.B. Saunders, Philadelphia, Pennsylvania, 2004.

21. Weinstein, G. S., Myers, E. N., Shapshay, S. M., Weber, R.: Nonsurgical treatment of laryngeal cancer. N Engl J Med 350(10): 1049-53; author reply 1049-53, 2004.

22. Hockstein, N., Weinstein, G.S., O'Malley, B.W.: Transoral Robotic Surgery (TORS). Robotics in Surgery: History, Current and Future Applications. Faust, R.A. (eds.). Nova Publishers, 2006.

23. Weinstein, GS, Laccourreye, O, Rassekh, C. : Early Glottic and Supraglottic Carcinoma: Open Supraglottic and Supracricord Partial Laryngectomy. Otolaryngology - Head and Neck Surgery. Bailey, B. et. al. (eds.). Lippincott - Raven, 2006.

Books:
1. Weinstein, G.S., Laccourreye, O., Brasnu, D., Laccourreye, H.: Organ Preservation Surgery for Laryngeal Cancer. Singular Publishing, Group, Inc, San Diego, California, 1999.

Alternative Media:
1. Weinstein, G.S. : Organ Preservation Surgery: Is total laryngectomy always needed after radiation failure? News form S.P.O.H.N.C., Vol. II, No.1. Support for People with Oral and Head and Neck Cancer, Inc. II(1), September 2001.

2. Basu, D.B., Truelson, J.M., Weinstein, G.S.: Management of the Neck With Carotid Artery Involvement. E-Medicine Online Textbook, and URL: http://www.emedicine.com/ent/TOPIC508.HTM 2006.

3. Lai, S.Y., Weinstein, G.S.: Conservation Laryngeal Surgery, Supracricoid Laryngectomy. E-Medicine Online Textbook, and URL: http://www.emedicine.com/ent/TOPIC570.HTM 2006.

4. Quon, H., Basu, D.B., Weinstein, G.S., Weng, H. : Radiation Therapy, Hypopharyngeal Cancer. E-Medicine Online Textbook, and URL: http://www.emedicine.com/ent/TOPIC585.HTM 2007.

5. Weinstein GS, O'Malley, BW: da Vinci Transoral Surgery Procedure Guide. Intuitive Surgical Training Publication. Intuitive Surgical, Inc. Page: 1-30, August 2008.


Grants:



Past:
A Single Center Retrospective Investigation of the use of the da Vinci Surgical System in Transoral Surgery (TORS) Targeting Patients with Oral and Laryngopharyngeal benign and malignant lesions , Intuitive Surgical, Inc. , 5/2008-2/2009 (Gregory Weinstein, M.D., PI), 1% effort (Role in grant: PI)

SCOR Hyperbaric Oxygen Therapy, NIH, 8/2004-7/2005 (Stephen Thom, M.D., PI), 3% effort (Role in grant: Co-investigator)

Phase III open label L/T study of Cervimuline, Daichi Corp., 3/2003-3/2005 (Gregory S. Weinstein, PI), 5% effort (Role in grant: PI)

Smoking Cessation Program for Head and Neck Cancer Patients, NIH/NCI, 6/2002-5/2004 (P. Garati, PI), , 2% effort (Role in grant: Co-investigator)

Phase II study of the safety and efficacy of allovectin-7 immunotherapy for the treatment of primary, resectable squamous cell carcinoma of the oral cavity and oropharynx. , Vical Corp., 6/2001-5/2002 (David Rosenthal, M.D., PI), , 1% effort (Role in grant: Co-Investigator)

A Phase I study of epirubicin, cisplatin and metastatic upper gastrointestinal, recurrent or metastatic squamous cell carcinoma of the head and neck and metastatic non-small cell lung cancer., Pharmacia, Corp., 3/2001-2/2002 (David Rosenthal, M.D., PI), 1% effort (Role in grant: Co-Investigator)

A phase III, multicenter, randomized double-blind, placebo-controlled study to assess the efficacy and safety of cevimeline in the treatment of xerostomia secondary to radiation therapy for cancer in the head and neck region, Daiichi, Corp., 1/2001-12/2002 (Gregory Weinstein, M.D., PI), 1% effort (Role in grant: Local PI)

Biochemoprevention followed by fenretinide versus placebo maintenance for advanced laryngal dysplasia, MD Anderson and NIH: Center for Scientific Review, 1/2000-1/2005 (Robert Lustig, M.D., PI), 1% effort (Role in grant: Co-investigator)

IFN Alpha/IL-12-2001 : An open label multiple administration, rising dose study of the safety, tolerability and efficacy of IFN alpha/II-12-2001 in patients with unresectable or recurrent/refraqctory sqaumous cell carcinoma of the neck, Valentis, Inc., 10/1999-9/2000 (Shelley McQuone, M.D., PI), 1% effort (Role in grant: Sub-investigator)

Interlukin 12: An open label multiple administration, rising dose study of the safety, tolerabolity and efficacy of Interleukin 12 in patients with unresectable or recurrent/refractory squamous cell carcinoma of the neck, Valentis, Inc., 8/1999-7/2000 (Shelley McQuone, M.D., PI), 1% effort (Role in grant: Co-Investigator)

IFN Alpha 1001: An open label multiple administration, rising dose study of safety, tolerability and efficacy of IFN alpha 1001 gene medicine in patients with unresectable or recurrent/refractory squamous cell carcinoma of the neck, Valentis, Inc. , 5/1999-4/2000 (Shelley McQuone, M.D., PI), 1% effort (Role in grant: Sub-investigator)

Phase I trial of Bi-weekly SPI-77 (Liposomal Cisplatin) with concurrent radiotherapy, Cequus/Alza Corp., 5/1999-4/2000 (David Rosenthal, M.D., PI), 1% effort (Role in grant: Co-Investigator)

A Phase I/II investigation of topotecan, paclitaxel, and carboplatin with G-csf metastatic and recurrent head and neck cancer. , In house/Smith Kline, 2/1999-1/2000 (Victor Aveles, M.D., PI), 1% effort (Role in grant: Co-Investigator)

HUP Phase II trial of combined modality therapy for oropharyngeal cancer, Bristol Myers Squibb, 3/1998-2/2002 (Mitchell Machtay, M.D., PI), 5% effort (Role in grant: Co-Investigator, Single Center/No Salary Support)

A randomized Phase II trial assessing human erythropoitin(EPO) and standard of care practices in patients with advanced head and neck cancer undergoing surgery. , Orthobiotec, Inc., 1/1997-12/2000 (Gregory S. Weinstein, PI), 5% effort (Role in grant: PI)

Selected Publications

Iocca Oreste, Sollecito Thomas P, Alawi Faizan, Weinstein Gregory S, Newman Jason G, De Virgilio Armando, Di Maio Pasquale, Spriano Giuseppe, Pardiñas López Simón, Shanti Rabie M: Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta-analysis of malignant transformation rate by subtype. Head & neck 42 (3): 539-555,2019.

Gershowitz Jared, Chao Hann-Hsiang, Doucette Abigail, Lukens John N, Swisher-McClure Samuel, Weinstein Gregory S, O'Malley Bert W, Chalian Ara A, Rassekh Christopher H, Newman Jason G, Cohen Roger B, Bauml Joshua M, Aggarwal Charu, Lin Alexander: Risk of post-operative, pre-radiotherapy contralateral neck recurrence in patients treated with surgery followed by adjuvant radiotherapy for human papilloma virus-associated tonsil cancer. The British journal of radiology 92 (1104): 20190466,2019.

Shah Ravi R, Weinstein Gregory S, Mirza Natasha A: Voice Restoration after Radiation and Supracricoid Partial Laryngectomy by Injection Augmentation of the Arytenoid. Journal of voice : official journal of the Voice Foundation : 2019.

Swisher-McClure Samuel, Lukens John N, Aggarwal Charu, Ahn Peter, Basu Devraj, Bauml Joshua M, Brody Robert, Chalian Ara, Cohen Roger B, Fotouhi-Ghiam Alireza, Geiger Geoffrey, Gershowitz Jared, Livolsi Virginia, Mitra Nandita, Montone Kathleen, Newman Jason, Ojerholm Eric, O'Malley Bert, Rajasekaran Karthik, Tan Erik, Weinstein Gregory, Lin Alexander: A Phase 2 Trial of Alternative Volumes of Oropharyngeal Irradiation for De-intensification (AVOID): Omission of the Resected Primary Tumor Bed After Transoral Robotic Surgery for Human Papilloma Virus-Related Squamous Cell Carcinoma of the Oropharynx. International journal of radiation oncology, biology, physics 106 (4): 725-732,2020.

Holsinger F Christopher, Magnuson J Scott, Weinstein Gregory S, Chan Jason Y K, Starmer Heather M, Tsang Raymond K Y, Wong Eddy W Y, Rassekh Christopher H, Bedi Nikita, Hong Steven S Y, Orosco Ryan, O'Malley Bert W, Moore Eric J: A Next-Generation Single-Port Robotic Surgical System for Transoral Robotic Surgery: Results From Prospective Nonrandomized Clinical Trials. JAMA otolaryngology-- head & neck surgery 145 : 1027-1034,2019.

Henry Laura E, Haugen Thorsen W, Rassekh Christopher H, Adappa Nithin D, Weinstein Gregory S, O'Malley Bert W: A novel transpalatal-transoral robotic surgery approach to clival chordomas extending into the nasopharynx. Head & neck : 2019.

Gomez Ernest D, Thaler Erica R, O'Malley Bert W, Rassekh Christopher H, Weinstein Gregory S, Newman Jason G, Brody Robert M: Techniques for developing and viewing stereoscopic three-dimensional teaching videos for transoral robotic surgery (TORS). Journal of robotic surgery : 2019.

Workman Alan D, Brody Robert M, Kuan Edward C, Baranov Esther, Brooks Steven G, Alonso-Basanta Michelle, Newman Jason G, Rassekh Christopher H, Chalian Ara A, Chiu Alexander G, Weinstein Gregory S, Feldman Michael D, Adappa Nithin D, O'Malley Bert W, Palmer James N: Sinonasal Undifferentiated Carcinoma: A 15-Year Single Institution Experience. Journal of neurological surgery. Part B, Skull base 80 (1): 88-95,2019.

Charu Aggarwal, Roger B. Cohen, Matthew P. Morrow, Kimberly A. Kraynyak, Albert J. Sylvester, Dawson M. Knoblock, Joshua M. Bauml, Gregory S. Weinstein, Alexander Lin, Jean Boyer, Lindsay Sakata, Sophie Tan, Aubrey Anton, Kelsie Dickerson, Drishty Mangrolia, Russell Vang, Michael Dallas, Sandra Oyola, Susan Duff, Mark Esser, Rakesh Kumar, David Weiner, Ildiko Csiki and Mark L. Bagarazzi: Immunotherapy Targeting HPV16/18 Generates Potent Immune Responses in HPV-Associated Head and Neck Cancer. Clinical Cancer Research 25 (1): 110-124,2019.

Chao Hann-Hsiang, Schonewolf Caitlin A, Tan Erik X, Swisher-McClure Samuel, Ghiam Alireza F, Weinstein Gregory S, O'Malley Bert W, Chalian Ara A, Rassekh Christopher H, Newman Jason G, Cohen Roger B, Bauml Joshua M, Aggarwal Charu, Lin Alexander, Lukens John N: The impact of treatment package time on locoregional control for HPV+ oropharyngeal squamous cell carcinoma treated with surgery and postoperative (chemo)radiation. Head & neck 41 (11): 3858-3868,2019.

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