Description of Research Expertise

Dr. Grunwald is world renowned for his research on blood flow in the retina. He has helped to develop techniques to measure the circulation in the eye. In his laboratory, the Vivian Simkins Lasko Retinal Vascular Research Laboratory, non-invasive state of the art technology is employed to study the role of circulatory changes in the development of vision-threatening eye diseases such as age-related macular degeneration (AMD), diabetic retinopathy, glaucoma, retinitis pigmentosa, and others and the pharmacologic effects of medications on the human ocular vasculature and its circulation.

Clinical Trials
Dr. Grunwald is an investigator on the following trials:
•Complications of Age-Related Macular Degeneration Prevention Trial (CAPT)
•The Comparison of Age-Related Macular Degeneration Treatments Trials (CATT)
•Retinopathy in Chronic Renal Insufficiency (RCRIC)

He is the Principal Investigator of two grants that will quantitate changes occurring in the retina due to diabetic retinopathy, systemic hypertension and age-related macular degeneration.

Keywords
Age-related macular degeneration (AMD), choroidal circulation, diabetic retinopathy, ocular vasculature, optic nerve blood flow, pharmacologic effects, retina, retinal circulation, retinal vasculature

Selected Publications

Cuilla TA, Ying GS, Maguire MG, Martin DF, Jaffe GJ, Grunwald JE, Daniel E, Toth CA: Influence of the Vitreomacular Interface on Treatment Outcomes in the Comparison of Age-Related Macular Degeneration Treatments Trials. Ophthalmology 122 (6): 1203-11,2015.

Altaweel MM, Daniel E, Martin DF, Mittra RA, Grunwald JE, Lai MM, Melamud A, Morse LS, Huang J, Ferris FL, Fine SL, Maguire MG: Outcomes of eyes with lesions composed of >50% blood in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT). Ophthalmology 122 (2): 391-398.e5,2015.

Gewaily DY, Grunwald JE, Pistilli M, Ying GS, Maguire MG, Daniel E, Ostroff CP, Fine SL: Delayed patchy choroidal filling in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). American journal of ophthalmology 158 (3): 525-31.e2,2014.

Ricardo AC, Grunwald JE, Parvathaneni S, Goodin S, Ching A, Lash JP: Retinopathy and CKD as predictors of all-cause and cardiovascular mortality: National Health and Nutrition Examination Survey (NHANES) 1988-1994. American journal of kidney diseases : the official journal of the National Kidney Foundation 64 (2): 198-203,2014.

Ying GS, Kim BJ, Maguire MG, Huang J, Daniel E, Jaffe GJ, Grunwald JE, Blinder KJ, Flaxel CJ, Rahhal F, Regillo C, Martin DF: Sustained visual acuity loss in the comparison of age-related macular degeneration treatments trials. JAMA ophthalmology 132 (8): 915-21,2014.

Daniel E, Toth CA, Grunwald JE, Jaffe GJ, Martin DF, Fine SL, Huang J, Ying GS, Hagstrom SA, Winter K, Maguire MG: Risk of scar in the comparison of age-related macular degeneration treatments trials. Ophthalmology 121 (3): 656-66,2014.

Scialla JJ, Xie H, Rahman M, Anderson AH, Isakova T, Ojo A, Zhang, Nessel L, Hamano T, Grunwald JE, Raj DS, Yang W, He J, Lash JP, Go AS, Kusek JW, Feldman H, Wolf M: Fibroblast growth factor-23 and cardiovascular events in CKD. Journal of the American Society of Nephrology : JASN 25 (2): 349-60,2014.

Maguire MG, Daniel E, Shah AR, Grunwald JE, Hagstrom SA, Avery RL, Huang J, Martin RW, Roth DB, Castellarin AA, Bakri SJ, Fine SL, Martin DF: Incidence of Choroidal Neovascularization in the Fellow Eye in the Comparison of Age-related Macular Degeneration Treatments Trials. Ophthalmology 120 (10): 2035-2041,2013.

Grunwald JE, Daniel E, Huang J, Ying GS, Maguire MG, Toth CA, Jaffe GJ, Fine SL, Blodi B, Klein ML, Martin AA, Hagstrom SA, Martin DF: Risk of Geographic Atrophy in the Comparison of Age-related Macular Degeneration Treatments Trials. Ophthalmology 121 (1): 150-61,2013.

Jaffe GJ, Martin DF, Toth CA, Daniel E, Maguire MG, Ying GS, Grunwald JE, Huang J: Macular Morphology and Visual Acuity in the Comparison of Age-related Macular Degeneration Treatments Trials. Ophthalmology 120 (9): 1860-70,2013.

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Academic Contact Information

Scheie Eye Institute
51 North 39th Street
2689
Philadelphia, PA 19104
Patient appointments: 800-789-7366