Matthew J. O'Connor, MD

Pediatric Cardiology

Sees newborns through age 18

Matthew J. O'Connor, MD

Pediatric Cardiology

Sees newborns through age 18

Dr. O'Connor is an independent physician who is not employed by Penn Medicine Lancaster General Health.

Call 717-544-0375 Request Appointment

Alagille Syndrome
Anomalies of the Aorta
Anomalous Coronary Artery
Anomalous Pulmonary Venous Return
Aortic Valve Disorders
Aortopulmonary Window
Arrhythmia (Irregular Heartbeat)
Athlete's Heart
Atrial Septal Defect (ASD)
Atrioventricular Canal Defect
Atrioventricular Septal Defect
Bacterial Endocarditis
Barth Syndrome
Bicuspid Aortic Valve Disease
Brugada Syndrome
Cardiomyopathy (Cardiomyopathies)
Cardio-Oncology
Cardiorenal Syndrome (CRS)
Common Aortopulmonary Trunk
Congenital Anomaly of the Aortic Arch
Congenital Anomaly of the Coronary Artery
Congenital Heart Disease
Congenital Infundibular Stenosis
Congenital Insufficiency of the Aortic Valve
Congenital Mitral Valve Regurgitation
Congenital Pulmonary Valve Atresia
Congenital Stenosis of the Aortic Valve
Congenital Stenosis of the Mitral Valve
Congenital Stenosis of the Pulmonary Valve
Congenital Subaortic Stenosis
Congenital Tricuspid Stenosis
Congenitally Corrected Transposition of the Great Arteries
Congestive Heart Failure (CHF)
Constrictive Pericarditis
Coronary Artery Anomaly
Coronary Artery Fistula
Cyanotic Heart Disease
Dextrocardia
Dilated Cardiomyopathy
Double Aortic Arch
Double Outlet Right Ventricle
Ebstein Anomaly
Ehlers-Danlos Syndrome
Eisenmenger Syndrome
Endocardial Cushion Defect
Familial Arrhythmias
Familial Cardiomyopathy
Familial Dyslipidemia
Fetal Arrhythmia
Fetal Cardiology
Fetal Cardiomyopathy
Genetic Cardiomyopathy
Genetic Heart Disease
Heart Block
Heart Murmur
Heart Tumor (Cardiac Tumor)
Hemitruncus
Hypertension (High Blood Pressure)
Hypertrophic Cardiomyopathy
Hypoplastic Left Heart Syndrome
Idiopathic Hypertrophic Subaortic Stenosis
Inherited Cardiac Arrhythmia
Kabuki Syndrome
Kawasaki Disease
Loeys-Dietz Syndrome
Long QT Syndrome
Marfan Syndrome
Mitral Stenosis
MTHFR Mutation
Partial Anomalous Pulmonary Venous Return
Patent Ductus Arteriosus
Patent Foramen Ovale (PFO)
Peripheral Pulmonary Stenosis
Persistent Ostium Primum
Pulmonary Artery Coarctation and Atresia
Pulmonary Artery Stenosis
Pulmonary Hypertension
Pulmonary Valve Disorders
Pulmonary Valve Insufficiency
Pulmonary Valve Stenosis (PVS)
Pulmonary Vein Stenosis
Pulmonary Veno Occlusive Disease
Restrictive Cardiomyopathy
Septal Defect
Subaortic Stenosis
Supravalvular Aortic Stenosis
Syncope
Tetralogy of Fallot
Transposition of the Great Vessels
Tricuspid Atresia
Truncus Arteriosus
Tufted Angioma
Twin Reversed Arterial Perfusion
Velo-Cardio-Facial Syndrome
Ventricular Septal Defect (VSD)
Viral Cardiomyopathy
Wolff-Parkinson-White Syndrome (WPW)

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Board Certification

Pediatrics, 2007
Pediatrics/Cardiology (AMA)

Education and Training

Medical School: University of Virginia
Residency: University of Virginia; University of Virginia Children's Hospital
Fellowship: Children's Hospital of Philadelphia

Primary Location

CHOP Specialty Care, Lancaster

Suite 300
2104 Harrisburg Pike
Lancaster, PA 17601

Map Call 717-544-0375

View details

Penn Medicine Hospital Privileges

Chester County Hospital: Has privileges to treat patients in the hospital.
Lancaster General Hospital: Has privileges to treat patients in the hospital.

Selected Publications

Bell S, Berger J, Boyle C, Edelson JB, Edwards JJ, Ha L, Lin KY, Maeda K, Rossano JW, Wittlieb-Weber CA, White R, O'Connor MJ: Characteristics and outcomes of children determined to be noncandidates for heart transplant JHLT Open 4 : 2024.

Kamsheh AM, Meyers KE, Palermo RA, Wu L, Burstein DS, Edelson JB, Lin KY, Maeda K, Rossano JW, Wittlieb-Weber CA, O'Connor MJ: Hypertension: an important but reversible cause of systolic dysfunction in a cohort of pediatric patients Pediatr Cardiol 45 : 331-339,2024.

Holzhauser L, Reza N, Edwards JJ, Birati EY, Owens AT, McLean R, Maeda K, O'Connor MJ, Rossano JW, Mondal A, Katcoff H, Edelson JB: Emergency department use and hospital mortality among heart transplant recipients in the United States J Am Heart Assoc 13 : e032676,2024.

Ybarra AM, Kamsheh AM, O'Connor MJ, Hollander SA, Bano M, Ploutz M, Vaughn G, Lambert A, Wallendorf M, Kirklin J, Canter CE: Survival does not differ by annual center transplant volume-A Pediatric Heart Transplant Society Registry study Pediatr Transplant 28 : e14720,2024.

Chen S, Shezad MF, Lorts A, McCormick AD, Mao CY, Simpson KE, O'Connor MJ, Barnes A, Lubert AM, Castleberry C, Schmidt J, Schroeder K, Joong A, Bearl DW, Lal AK, Mokshagundam D, Conway J, Cedars A, Schumacher KR: Outcomes after initial heart failure consultation in Fontan patients Cardiol Young : 1-8,2023.

Bansal N, D'Souza N, Wisotzkey BL, Albers E, Shih R, Exil V, McQueen M, Hillenburg JP, Azeka E, Law S, Peng DM, O'Connor M, Gajarski R, Vanderpluym C, Lorts A, Barnes A, Sojka M, Bano M, Keating M, Rosenthal DN, Conway J, Schroeder K, Nandi D: Successful implementation of telehealth visits in the paediatric heart failure and heart transplant population Pediatr Cardiol : 2023.

Edwards J, Mejia E, Boyle C, Ha L, O'Connor M, Joshi P, White R, Rossano J, Berger J, Wittlieb-Weber C, Lin K, Maeda K, Edelson J: Donor derived cell free DNA is correlated with DSA and rejection in pediatric heart transplant recipients International Society for Heart and Lung Transplantation 2023 Annual Meeting, Denver, CO (poster presentation) : 2023.

Bell S, Berger J, Boyle C, Edelson JB, Edwards JJ, Ha L, Lin KY, Maeda K, Rossano JW, Wittlieb-Weber C, White R, O'Connor MJ: Characteristics and outcomes of children determined not to be candidates for heart transplantation International Society for Heart and Lung Transplantation 2023 Annual Meeting, Denver, CO (poster presentation) : 2023.

Kamsheh AM, Bilker WB, Okunowo O, Burstein DS, Edelson JB, Lin KY, Maeda K, Mavroudis CD, O'Connor MJ, Wittlieb-Weber C, Bogner HR, Rossano JW: Prolonged inotrope use after surgery for congenital heart disease: risk factors for inpatient mortality International Society for Heart and Lung Transplantation 2023 Annual Meeting, Denver CO (poster presentation) : 2023.

Rabinowitz EJ, Mehegan M, Joong A, Shezad M, Griffiths E, O'Connor MJ, Mokshagundam D, Said AS: Post-stage 2 palliation single ventricular assist device outcomes: an Advanced Cardiac Therapies Improving Outcomes Network (Action) Registry analysis International Society for Heart and Lung Transplantation 2023 Annual Meeting, Denver CO (platform presentation) : 2023.

Academic Contact Information

Children's Hospital of Philadelphia
Division of Cardiology
3401 Civic Center Blvd
Philadelphia, PA 19104
Phone: 267-426-5700
Patient appointments: 800-789-7366

ACTION-Advanced Cardiac Therapies Improving Outcomes Network, National
American Heart Association, National
International Society for Heart and Lung Transplantation, International
United Network for Organ Sharing, National