Description of Research Expertise
My long-term research interest is in the molecular pathways that facilitate cross talk between intestinal epithelial cells and the immune system in order to modulate the outcomes of infections, inflammatory processes and cancer. Specifically, my laboratory focuses on understanding how the epithelial layer repairs itself after injury, how epithelial cells prevent deleterious changes that lead to tumorigenesis in the face of chronic inflammation and how epithelial cells influence the immune landscape.
Selected Publications
Belle NM: M1 and M2 Macrophages Differentially Regulate Colonic Crypt Renewal PracticeUpdate website : 2024.
Lucas M Ethgen, Christopher Pastore, Cailu Lin, Danielle R Reed, Li-Yin Hung, Bonnie Douglas, Dominic Sinker, De'Broski R Herbert, Nicole M Belle: A Trefoil factor 3- Lingo2 axis restrains proliferative expansion of type-1 T helper cells during GI nematode infection Mucosal Immunology 17 (2): 238-256,2024.
Nicole Belle, Christopher Pastore, Lucas Ethgen, De'Broski Herbert: LINGO2 expression on T cells promote anti-helminth immunity DDW 2022 : 2022.
Zullo, K.M, Douglas, B., Maloney N., Yingbiao J, Yun W, Herbine K, Cohen R, Pastore C, Cramer Z, Wang X, Wenjie W, Somsouk M, Hung L.Y., Lengner C, Kohanksi M.H., Cohen N.A and D. R. Herbert: LINGO3 regulates mucosal tissue regeneration and promotes TFF2 dependent recovery from colitis Scand J. Gastroenterology 56 (7): 791-805,2021.
Nicole M Belle, Christopher Pastore, Erin Jean and De'Broski R Herbert: LINGO2 expression on T cells selectively promotes anti-helminth immunity Virtual Immunology : 2021.
Nicole Belle: Model System Has Answered Critical Questions GI & Hepatology News : 2020.
Nicole M Belle, Erin Jean, Joon Park and De’broski Herbert: T cell expression of the transmembrane receptor, LINGO2 controls helminth induced colitis Mucosal Immunology Course & Symposium : 2020.
Belle NM, Ji Y, Wei Y, Park J, Srivatsa S, Hung LY, Young T, Herbine K, Oniskey T, Pastore C, Nieves W, Somsouk M, Herbert DR: TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths Nature Communications 10 (1): 4408,2019.
Maloney NS, Thackray LB, Goel G, Hwang S, Duan E, Vachharajani P, Xavier R, Virgin HW: Essential cell autonomous role for interferon regulatory factor 1 in interferon-γ-mediated inhibition of norovirus replication in macrophages J. Virol 86 (23): 12655-64,2012.
Hwang S, Maloney NS, Bruinsma MW, Goel G, Duan E, Zhang L, Shrestha B, Diamond MS, Dani A, Sosnovtsev SV, Green KY, Lopez-Otin C, Xavier RJ, Thackray LB, Virgin HW: Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma Cell Host Microbe 11 (4): 397-09,2012.
Academic Contact Information
Perelman Center for Advanced Medicine
7 South Pavilion
Philadelphia,
PA
19104
Phone: 215-349-8222