Description of Research Expertise

Dr. Meyer identifies genetic and molecular risk factors for acute respiratory distress syndrome (ARDS) and organ dysfunction during sepsis to better understand the pathophysiology of these conditions and to seek novel treatments. The goal of her work is to develop personalized therapy for sepsis and ARDS. Her research program includes:

1) A large observational cohort of critically ill subjects with sepsis including COVID-19 pneumonia phenotyped for infection subtype, comorbidities, survival, ARDS, acute kidney injury (AKI), and cognitive impairment
2) Discovery and validation of genetic and molecular risk factors for sepsis-associated organ dysfunction
3) Clinical trials for ARDS and sepsis [Active: iSPY COVID; CHILL cooling to heal injured lungs]

Selected Publications

Mathew D, Giles JR, Baxter AE, Oldridge DA, Greenplate AR, Wu JE, Alanio C, Kuri-Cervantes L, Pampena MB, D'Andrea K, Manne S, Chen Z, Huang YJ, Reilly JP, Weisman AR, Ittner CAG, Kuthuru O, Dougherty J, Nzingha K, Han N, Kim J, Pattekar A, Goodwin EC, Anderson EM, Weirick ME, Gouma S, Arevalo CP, Bolton MJ, Chen F, Lacey SF, Ramage H, Cherry S, Hensley SE, Apostolidis SA, Huang AC, Vella LA, U Penn COVID Processing Unit, Betts MR, Meyer NJ, Wherry EJ: Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications Science 369 (6508): eabc8511,2020.

Kuri-Cervantes L, Pampena MB, Meng W, Rosenfeld AM, Ittner CAG, Weisman, AR, Agyekum RS, Mathew D, Baxter AE, Vella LA, Kuthuru O, Apostolidis SA, Bershaw L, Dougherty J, Greenplate AR, Pattekar A, Kim J, Han N, Gouma S, Weirick ME, Arevalo CP, Bolton MJ, Goodwin EC, Anderson EM, Hensley SE, Jones TK, Mangalmurti NS, Luning Prak ET, Wherry EJ, Meyer NJ, Betts MR: Comprehensive mapping of immune perturbations associated with severe COVID-19 Sci Immunol 5 (49): eabd7114,2020.

Guillen-Guio Beatriz, Lorenzo-Salazar Jose M, Ma Shwu-Fan, Hou Pei-Chi, Hernandez-Beeftink Tamara, Corrales Almudena, García-Laorden M Isabel, Jou Jonathan, Espinosa Elena, Muriel Arturo, Domínguez David, Lorente Leonardo, Martín María M, Rodríguez-Gallego Carlos, Solé-Violán Jordi, Ambrós Alfonso, Carriedo Demetrio, Blanco Jesús, Añón José M, Reilly John P, Jones Tiffanie K, Ittner Caroline Ag, Feng Rui, Schöneweck Franziska, Kiehntopf Michael, Noth Imre, Scholz Markus, Brunkhorst Frank M, Scherag André, Meyer Nuala J, Villar Jesús, Flores Carlos: Sepsis-associated acute respiratory distress syndrome in individuals of European ancestry: a genome-wide association study. The Lancet. Respiratory medicine 8 (3): 258-266,2020.

Reilly JP, Wang F, Jones TK, Palakshappa JA, Anderson BJ, Shashaty MGS, Dunn TG, Johansson ED, Riley TR, Lim B, Abbott J, Ittner CAG, Cantu E, Lin X, Mikacenic C, Wurfel MM, Christiani DC, Calfee CS, Matthay MA, Christie JD, Feng R, Meyer NJ: Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis. Intensive Care Med 44 (11): 1849-1858,2018.

Meyer Nuala J, Reilly John P, Anderson Brian J, Palakshappa Jessica A, Jones Tiffanie K, Dunn Thomas G, Shashaty Michael G S, Feng Rui, Christie Jason D, Opal Steven M: Mortality Benefit of Recombinant Human Interleukin-1 Receptor Antagonist for Sepsis Varies by Initial Interleukin-1 Receptor Antagonist Plasma Concentration. Critical care medicine 46 (1): 21-28,2018.

Reilly JP, Meyer NJ. Shashaty MGS, Anderson BJ, Ittner CAG, Dunn TG, Lim B, Forker CM, Bonk MP, Kotloff ED, Feng R, Cantu E, Mangalmurti NS, Calfee CS, Matthay MA, Mikacenic C, Walley KR, Russell JA, Christiani DC, Wurfel MM, Lanken PN, Reilly MP, Christie JD: The ABO Histo-Blood Group, endothelial activation, and acute respiratory distress syndrome risk in critical illness J Clin Invest 131 (1): e139700,2021.

Jones TK, Feng R, Kerchberger VE, Reilly JP, Anderson BJ, Shashaty MGS, Wang F, Dunn TG, Riley TR, Abbott J, Ittner CAG, Christiani DC, Mikacenic C, Wurfel MM, Ware LB, Calfee CS, Matthay MA, Christie JD, Meyer NJ: Plasma sRAGE Acts as Genetically Regulated Causal Intermediate in Sepsis-Associated ARDS. Am J Respir Crit Care Med 201 (1): 47-56,2020.

Meyer NJ, Reilly JP, Feng R, Christie JD, Hazen SL, Albert CJ, Franke JD, Hartman CL, McHowat J, Ford DA: Myeloperoxidase-derived 2-chlorofatty acids contribute to human sepsis mortality via acute respiratory distress syndrome. JCI Insight 2 (23): e96432,2017.

Meyer Nuala J, Calfee Carolyn S: Novel translational approaches to the search for precision therapies for acute respiratory distress syndrome. The Lancet. Respiratory medicine 5 (6): 512-523,2017.

Palakshappa Jessica A, Meyer Nuala J: Which Patients with ARDS Benefit from Lung Biopsy? Chest 148 (4): 1073-1082,2015.

View all publications

Academic Contact Information

Division of Pulmonary and Critical Care Medicine
Hospital of the University of Pennsylvania
3400 Spruce Street
5037 Gates Building
Philadelphia, PA 19104
Phone: 215-662-7049
Patient appointments: 800-789-7366