Description of Research Expertise

Dr. Jones is a physician-epidemiologist who investigates the risk factors for respiratory failure during critical illness with a focus on the determinants of acute respiratory distress syndrome (ARDS). She conducts studies that apply her knowledge in pulmonary and critical care medicine, clinical epidemiology, genetic epidemiology, and public health. The purpose of her research is to identify novel genetic determinants of ARDS to elucidate the underlying biology, identify new targets for disease-specific pharmacotherapy, and advance a precision medicine paradigm for treatment of critical illness.

Selected Publications

Jones TK, Reilly JP, Anderson BJ, Miano TA, Dunn TG, Turner AP, Agyekum RS, Feng R, Ittner CAG, Shashaty MGS, Meyer NJ.: ARDS Mediates the Association Between Early Plasma sRAGE Concentrations and Mortality in Sepsis Am J Respir Crit Care Med 208 (5): 628-630,2023.

Cosgriff CV, Miano TA, Mathew D, Huang AC, Giannini HM, Kuri-Cervantes L, Pampena MB, Ittner CAG, Weisman AR, Agyekum RS, Dunn TG, Oniyide O, Turner AP, D'Andrea K, Adamski S, Greenplate AR, Anderson BJ, Harhay MO, Jones TK, Reilly JP, Mangalmurti NS, Shashaty MGS, Betts MR, Wherry EJ, Meyer NJ.: Validating a Proteomic Signature of Severe COVID-19 Crit Care Explor 4 (12): e0800,2022.

Hernandez-Beeftink T, Guillen-Guio B, Lorenzo-Salazar JM, Corrales A, Suarez-Pajes E, Feng R, Rubio-Rodríguez LA, Paynton ML, Cruz R, García-Laorden MI, Prieto-González M, Rodríguez-Pérez A, Carriedo D, Blanco J, Ambrós A, González-Higueras E, Espinosa E, Muriel A, Tamayo E, Martin MM, Lorente L, Domínguez D, de Lorenzo AG, Giannini HM, Reilly JP, Jones TK, Añón JM, Soro M, Carracedo Á, Wain LV, Meyer NJ, Villar J, Flores C; Genetics of Sepsis (GEN-SEP) Network.: A genome-wide association study of survival in patients with sepsis Crit Care 26 (1): 341,2022.

Miano TA, Hennessy S, Yang W, Dunn TG, Weisman AR, Oniyide O, Agyekum RS, Turner AP, Ittner CAG, Anderson BJ, Wilson FP, Townsend R, Reilly JP, Giannini HM, Cosgriff CV, Jones TK, Meyer NJ, Shashaty MGS.: Association of vancomycin plus piperacillin-tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study Intensive Care Med 48 (9): 1144-1155,2022.

Belvitch P, Casanova N, Sun X, Camp SM, Sammani S, Brown ME, Mascarhenas J, Lynn H, Adyshev D, Siegler J, Desai A, Seyed-Saadat L, Rizzo A, Bime C, Shekhawat GS, Dravid VP, Reilly JP, Jones TK, Feng R, Letsiou E, Meyer NJ, Ellis N, Garcia JGN, Dudek SM.: A cortactin CTTN coding SNP contributes to lung vascular permeability and inflammatory disease severity in African descent subjects Transl Res 244 : 56-74,2022.

Jones TK, Reilly JP, Anderson BJ, Miano TA, Dunn TG, Weisman AR, Agyekum R, Feng R, Ittner CAG, Shashaty MGS, Meyer NJ.: Elevated Plasma Levels of Matrix Metalloproteinase-3 and Tissue-Inhibitor of Matrix Metalloproteinases-1 Associate with Organ Dysfunction and Mortality in Sepsis Shock 57 (1): 41-47,2022.

Jones Tiffanie K, Feng Rui, Kerchberger V Eric, Reilly John P, Anderson Brian J, Shashaty Michael G S, Wang Fan, Dunn Thomas G, Riley Thomas R, Abbott Jason, Ittner Caroline A G, Christiani David C, Mikacenic Carmen, Wurfel Mark M, Ware Lorraine B, Calfee Carolyn S, Matthay Michael A, Christie Jason D, Meyer Nuala J: Plasma sRAGE Acts as Genetically Regulated Causal Intermediate in Sepsis-Associated ARDS. American journal of respiratory and critical care medicine 201 (1): 47-56,2020.

Guillen-Guio Beatriz, Lorenzo-Salazar Jose M, Ma Shwu-Fan, Hou Pei-Chi, Hernandez-Beeftink Tamara, Corrales Almudena, García-Laorden M Isabel, Jou Jonathan, Espinosa Elena, Muriel Arturo, Domínguez David, Lorente Leonardo, Martín María M, Rodríguez-Gallego Carlos, Solé-Violán Jordi, Ambrós Alfonso, Carriedo Demetrio, Blanco Jesús, Añón José M, Reilly John P, Jones Tiffanie K, Ittner Caroline Ag, Feng Rui, Schöneweck Franziska, Kiehntopf Michael, Noth Imre, Scholz Markus, Brunkhorst Frank M, Scherag André, Meyer Nuala J, Villar Jesús, Flores Carlos: Sepsis-associated acute respiratory distress syndrome in individuals of European ancestry: a genome-wide association study. The Lancet. Respiratory medicine 8 (3): 258-266,2020.

Wu Ann Chen, Kiley James P, Noel Patricia J, Amur Shashi, Burchard Esteban G, Clancy John P, Galanter Joshua, Inada Maki, Jones Tiffanie K, Kropski Jonathan A, Loyd James E, Nogee Lawrence M, Raby Benjamin A, Rogers Angela J, Schwartz David A, Sin Don D, Spira Avrum, Weiss Scott T, Young Lisa R, Himes Blanca E: Current Status and Future Opportunities in Lung Precision Medicine Research with a Focus on Biomarkers. An American Thoracic Society/National Heart, Lung, and Blood Institute Research Statement. American journal of respiratory and critical care medicine 198 (12): e116-e136,2018.

Reilly John P, Wang Fan, Jones Tiffanie K, Palakshappa Jessica A, Anderson Brian J, Shashaty Michael G S, Dunn Thomas G, Johansson Erik D, Riley Thomas R, Lim Brian, Abbott Jason, Ittner Caroline A G, Cantu Edward, Lin Xihong, Mikacenic Carmen, Wurfel Mark M, Christiani David C, Calfee Carolyn S, Matthay Michael A, Christie Jason D, Feng Rui, Meyer Nuala J: Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis. Intensive care medicine 44 (11): 1849-1858,2018.

Academic Contact Information

Hospital of the University of Pennsylvania
5048 Gates Building
3400 Spruce Street
Philadelphia, PA 19104
Phone: 215-662-3202