Description of Research Expertise

The Resnick laboratory studies cell signaling cascades and their alterations in pediatric brain tumors. The goal of the laboratory is to elucidate the molecular and genetic underpinnings of pediatric brain tumors in an effort to identify and develop targeted therapies. Additional, related studies focus on the characterization of novel cell signaling cascades impinging on cancer biology, including the inositol polyphosphates and their associated metabolism. Dr. Resnick also leads a number of Open Data initiatives focused on genomic data sharing and the necessary infrastructure to support collaborative research efforts.

Key words: brain, central nervous system, development, molecular oncology, neurooncology, signaling, inositol polyphosphates, and transcriptional regulation, cell and molecular biology, neuroscience, Brain Tumors.

Selected Publications

Kim S, Kim SF, Maag D, Maxwell MJ, Resnick AC, Juluri KR, Chakraborty A, Koldobskiy MA, Cha SH, Barrow R, Snowman AM, Snyder SH.: Amino Acid Signaling to mTOR Mediated by Inositol Polyphosphate Multikinase. Cell Metab. 13 (2): 215-21,2011.

Parsons DW, Li M, Zhang X, Jones S, Leary RJ, Lin JC, Boca SM, Carter H, Samayoa J, Bettegowda C, Gallia GL, Jallo GI, Binder ZA, Nikolsky Y, Hartigan J, Smith DR, Gerhard DS, Fults DW, VandenBerg S, Berger MS, Marie SK, Shinjo SM, Clara C, Phillips PC, Minturn JE, Biegel JA, Judkins AR, Resnick AC, Storm PB, Curran T, He Y, Rasheed BA, Friedman HS, Keir ST, McLendon R, Northcott PA, Taylor MD, Burger PC, Riggins GJ, Karchin R, Parmigiani G, Bigner DD, Yan H, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The genetic landscape of the childhood cancer medulloblastoma Science 331 (6016): 435-9,2011.

Maag D, Maxwell MJ, Hardesty DA, Boucher KL, Choudhari N, Hanno AG, Ma JF, Snowman AS, Pietropaoli JW, Xu R, Storm PB, Saiardi A, Snyder SH, Resnick AC: Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB. Proc Natl Acad Sci U S A. 108 (4): 1391-6,2011.

Lucy S. Chong, Katie L. Boucher, Namrata Choudhari, James H. Stephen, Phillip B. Storm, and Adam C. Resnick: An antibody-based approach for the detection of IP7-mediated protein phosphorylation Keystone Symposia 2011, Inositide Signalng in Pharmacology and Disease : 2011.

Dougherty MJ, Santi M, Brose MS, Ma C, Resnick AC, Sievert AJ, Storm PB, Biegel JA.: Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas Neuro Oncol 12 (7): 621-630,2010.

Sievert AJ, Choudhari N, Boucher K, Sharma S, Judkins AR, Biegel JA, Phillips PC, Storm PB, and Resnick AC: Molecular characterization and targeting of pediatric low-grade gliomas 14th International Symposium on Pediatric Neuro-Oncology : 2010.

Stephens JH, Sievert AJ, Resnick AC, Storm PB, Judkins AR, and Santi M: Clinicopathological and molecular characterization of pediatric myxopapillary ependymoma 2010 Society for NeuroOncology Annual Scientific Meeting : 2010.

Losito O, Szijgyarto Z, Resnick AC, Saiardi A: Inositol pyrophosphates and their unique metabolic complexity: analysis by gel electrophoresis. PLoS ONE 4 (5): e5580,2009.

Resnick AC & Saiardi A: Inositol Phosphates Wiley Encyclopedia of Chemical Biology : 1-12,2009.

D.A. Hardesty, D.A. Bhowmick, P.H. Kwag, P.B. Storm, A.C. Resnick: Knockdown of Inositol Polyphosphate Multikinase Modulates Glioblastoma Cellular Proliferation and AKT Activity in vitro. 2009 American Association of Neurological Surgeons Annual Meeting : 2009.

Saiardi Adolfo, Resnick Adam C, Snowman Adele M, Wendland Beverly, Snyder Solomon H: Inositol pyrophosphates regulate cell death and telomere length through phosphoinositide 3-kinase-related protein kinases. Proceedings of the National Academy of Sciences of the United States of America 102 (6): 1911-4,2005.

Resnick Adam C, Snowman Adele M, Kang Bingnan N, Hurt K Joseph, Snyder Solomon H, Saiardi Adolfo: Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity. Proceedings of the National Academy of Sciences of the United States of America 102 (36): 12783-8,2005.

Bhandari Rashna, Saiardi Adolfo, Ahmadibeni Yousef, Snowman Adele M, Resnick Adam C, Kristiansen Troels Z, Molina Henrik, Pandey Akhilesh, Werner J Kent, Juluri Krishna R, Xu Yong, Prestwich Glenn D, Parang Keykavous, Snyder Solomon H: Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event. Proceedings of the National Academy of Sciences of the United States of America 104 (39): 15305-10,2007.

Resnick Adam Cain, Saiardi Adolfo: Inositol polyphosphate multikinase: metabolic architect of nuclear inositides. Frontiers in bioscience : a journal and virtual library 1 (13): 856-66,2008.

Bhandari Rashna, Juluri Krishna R, Resnick Adam C, Snyder Solomon H: Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis. Proceedings of the National Academy of Sciences of the United States of America 105 (7): 2349-53,2008.

Sievert AJ, Jackson EM, Gai X, Hakonarson H, Judkins AR, Resnick AC, Sutton LN, Storm PB, Shaikh TH, Biegel JA: Duplication of 7q34 in Pediatric Low-Grade Astrocytomas Detected by High-Density Single-Nucleotide Polymorphism-Based Genotype Arrays Results in a Novel BRAF Fusion Gene. Brain pathology (Zurich, Switzerland) 19 (3): 449-458,2009.

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Academic Contact Information

Colket Translational Research Bldg
Rm. 4052 (office) / Rm. 4400 (Lab)
The Children's Hospital of Philadelphia
3501 Civic Center Blvd
Philadelphia, PA 19104
Phone: 267-425-2096