Description of Research Expertise
Phase I-II clinical trials (COPD, critical care, pulmonary hypertension, respiratory viral infection, Hepatitis B)
Selected Publications
Esther CR, Lazaar AL, Bordonali E, Qaqish B, Boucher RC: Elevated airway purines in chronic obstructive pulmonary disease Chest 140 (4): 954-960,2011.
Lazaar AL, Sweeney LE, MacDonald AJ, Alexis NE, Chen C, Deans A, Tal-Singer R: SB-656933, a novel CXCR2 selective antagonist, inhibits ex-vivo neutrophil activation and ozone-induced airway inflammation in humans British Journal of Clinical Pharmacology 72 (2): 282-293,2011.
Singh D, Petavy F, Macdonald AJ, Lazaar A and O`Connor BJ: The inhaled phosphodiesterase 4 inhibitor GSK256066 inhibits allergen challenge responses in asthma Respiratory Research 11 (1): 26,2010.
Kim JH, Van Biesen C, Lazaar AL: VEGF alters tracheal ring force generation in a rho-dependent manner Am J Respir Crit Care Med 169 : A445,2004.
Kazi AS, Lotfi S, Krymskaya VP, Lazaar AL.: Vascular endothelial growth factor (VEGF) up regulates fibronectin and matrix metalloproteinase-2 (MMP-2) secretion by human airway smooth muscle cells Am J Respir Crit Care Med 167 : A689,2003.
Goncharova EA, Goncharov DA, Panettieri RA, Lazaar AL, Krymskaya VP.: VEGF stimulates proliferation and migration of LAM-derived cells Am J Respir Crit Care Med 167 : A953,2003.
Kim JH, Ammit AJ, Puré E, Lazaar AL.: Hyaluronan activates NF-kB and induces IL-6 by human airway smooth muscle cells Am J Respir Crit Care Med 167 : A690,2003.
Lazaar AL, Panettieri RA: Airway Smooth Muscle: An Immunomodulatory Cell? Therapeutic Targets in Airway Inflammation 177 : 767-780,2003.
Lazaar AL, Albelda SM, Pilewski JM, Brennan B, Pure E, Panettieri RA Jr.: T lymphocytes adhere to airway smooth muscle cells via integrins and CD44 and induce smooth muscle cell DNA synthesis Journal of Experimental Medicine 180 (3): 807-16,1994.
Academic Contact Information
Penn Medicine University City
3737 Market Street
10th floor
Philadelphia,
PA
19104-4318
Phone: 215-662-8766
Patient appointments: 800-789-7366