Penn Medicine Provider
Medical Oncology
Angela DeMichele, MD, MSCE
5.0
(230)
Accepting new patients
Sees patients age 18 and up
Rena Rowan Breast Center

About me

  • Co-Leader, Breast Cancer Research Program
  • Co-Director, 2-PREVENT Breast Cancer Translational Center of Excellence
  • Mariann T. and Robert J. MacDonald Professor in Breast Cancer Care Excellence

Dr. DeMichele specializes in developing new therapies for breast cancer, neoadjuvant therapy  and preventing breast cancer recurrence.

Co-Chair of the ECOG/ACRIN Cooperative Group Breast Committee; Chair, Trial Operations Working Group, I-SPY Consortium; Member of the NCI Breast Cancer Steering Committee

Education and training

  • Medical School: Washington University in St. Louis
  • Residency: Hospital of the University of Pennsylvania
  • Fellowship: University of Bologna School of Medicine
  • Fellowship: Hospital of the University of Pennsylvania

What my patients think about me

Average Rating
5.0

230 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

July 2025
5.0
5.0
compassionate, knowledgeable
July 2025
5.0
5.0
dr. demichele is so thorough and makes me feel like she cares for me and my health.
July 2025
5.0
5.0
she is the right mix of friendly, smart, awe inspiring, sweet and empathetic. and her knowledge and curiosity and love for her field shines through.
July 2025
5.0
5.0
Dr. Demichele is very trustworthy and real

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
Dr. DeMichele is a Penn Medicine physician.

Qualifications and experience

My research

Mukhtar, R. A., Dimitroff, K., Yau, C., Chien, A. J., Connolly, E. P., Howard-McNatt, M., Rao, R., Ladores, V., Golshan, M., Sauder, C. A., Ahmed, K., Lancaster, R., Fox, J., Gutnik, L., Lee, M. C., Tchou, J., Prionas, N., Arciero, C. A., Reyna, C., Kuerer, H., Switalla, K., Taunk, N., Tuttle, T. M., Moran, M. S., Postlewait, L. M., Perlmutter, J., DeMichele, A., Yee, D., Hylton, N., Symmans, W. F., Rugo, H. S., Shatsky, R., Isaacs, C., Esserman, L. J., Van't Veer, L., Boughey, J. C. Impact of Neoadjuvant Chemotherapy on Surgical Outcomes and Conversion to Node-Negativity in Invasive Lobular Breast Cancer: Analysis of Molecularly High-Risk Tumors by Histologic Subtype on the I-SPY2 Clinical Trial , Annals of surgical oncology: 2025


Villacampa, G., Pascual, T., Tarantino, P., Cortés, J., Perez-García, J., Llombart-Cussac, A., Conte, P., Mancino, M., Guarneri, V., Dieci, M. V., Waks, A. G., Schettini, F., Brasó-Maristany, F., Griguolo, G., de Castro, B. A., Reboredo, C., Antolín, S., Bueno-Muiño, C., Echavarría, I., López-Tarruella, S., Massarrah, T., Monte-Millán, M. D., Martin, M., Buckingham, W., Parker, J. S., Vivancos, A., Polyak, K., Filho, O. M., Wolff, A. C., DeMichele, A., Tung, N. M., Perou, C. M., Paré, L., Villagrasa, P., Prat, A., Tolaney, S. M. HER2DX and survival outcomes in early-stage HER2-positive breast cancer: an individual patient-level meta-analysis , Lancet Oncology: 2025


Kaur, M., Dimitroff, K., Boughey, J. C., Esserman, L. J., Yau, C., Tchou, J., Quirarte, A., Lee, M. C., Howard-McNatt, M. M., Switalla, K., Kuerer, H., Sauder, C., Postlewait, L. M., Arciero, C., Rao, R., Wallace, A., Reyna, C., Ahmed, K., Gutnik, L., Taunk, N., Perlmutter, J., DeMichele, A., Yee, D., Yee, D., Hylton, N., Symmans, W. F., Rugo, H. S., Shatsky, R., Isaacs, C., Rudra, S., Pohlmann, P., Ewing, C., Wong, J., Alvarado, M., Jaskowiak, N., Prionas, N., Golshan, M., Piltin, M. A., Olopade, O. I., Mukhtar, R. A. Disparities in the Surgical Management of the Axilla by Self-Identified Race in the Multicenter Neoadjuvant I-SPY2 Trial , Annals of surgical oncology: 2025


Shinn, E., Zahrieh, D., DeMichele, A., Zdenkowski, N., Lemieux, J., Mao, J., Bjelic-Radisic, V., Naughton, M. J., Pfeiler, G., Gelmon, K., Balko, J. M., Egle, D., Zoppoli, G., Traina, T., Jimenez, M. M., Novoa, S. A., Haddad, T., Chan, A., Ring, A., Wolff, A., Symanns, W. F., Lorenzo, J. P., Sabanatha, D., Burstein. H. J., Bellet-Ezquerra, M., Foukakis, T., Novik, Y., Rubovszky, G., Singer, C. F., Muehlbacher, K., Filho, O. M., Goulioti, T., Law, E., Partridge, A. H., Carey, L. A., Zoroufy, A., Hlauschek, D., Fesl, C., Mayer, E. L., Gnant, M. Impact of adding palbociclib on treatment adherence to ongoing adjuvant endocrine treatment in the global randomized PALLAS randomized trial in patients with early breast cancer , Breast Cancer Res Treat: 2025


Wolf, D. M., Yau, C., Campbell, M., Glas, A., Barcaru, A., Mittempergher, L., Kuilman, M., Brown-Swigart, L., Hirst, G., Basu, A., Magbanua, M., Sayaman, R., Huppert, L., Delson, A., I-SPY2 Investigators, Symmans, W. F., Borowsky, A., Pohlmann, P., Rugo, H., Clark, A., Yee, D., DeMichele, A., Perlmutter, J., Petricoin, E. F., Chein, J., Stringer-Reasor, E., Shatsky, R., Liu, M., Han, H., Soliman, H., Isaacs, C., Nanda, R., Hylton, N., Pusztai, L., Esserman, L., van 't Veer, L. Immune Subtyping Identifies Patients With Hormone Receptor-Positive Early-Stage Breast Cancer Who Respond to Neoadjuvant Immunotherapy (IO): Results From Five IO Arms of the I-SPY2 Trial , JCO Precis Oncol: 2025


Hahnen, E., Hauke, J., Gelmon, K., Marmé, F., Ernst, C., Martin, M., Untch, M., Bonnefoi, H., Knudsen, E., Im, S.-A., DeMichele, A., Van’t Veer, L., Kim, S.-B., Bear, H., McCarthy, N., Rhiem, K., Turner, N., Witkiewicz, A., Rojo, F., Filipits, M., Martin, LA., Fasching, P. A., Schem, C., Becker, K., García-Sáenz, J. A., Kelly, C. M., Reimer, T., Toi, M., Rugo, H. S., Denkert, C., Gnant, M., Makris, A., Liu, Y., Valota, O., Felder, B., Weber, K., Nekljudova, V., Loibl, S. BRCA1/2 and Other Predisposition Genes in High-Risk Hormone Receptor+/Human Epidermal Growth Factor Receptor 2- Breast Cancer Treated With Endocrine Therapy With or Without Palbociclib: A Secondary PENELOPE-B Study Analysis , JCO Precision Oncology: 2025


Thomas, A., Mayer, E. L., DeMichele, A., Harbeck, N., Curigliano, G., Ignatiadis, M., Adam, V., Zhou, Y., Brown, T. P., Gilham, L., Chua, B. H., Kalinsky, K., Wolff, A. C., & O'Reilly, S. Further Optimizing Care of Patients With Operable Hormone Receptor-Sensitive Breast Cancer , J Clin Oncol: 2025


Huppert, L. A., Wolf, D., Yau, C., Brown-Swigart, L., Hirst, G. L., Isaacs, C., Pusztai, L., Pohlmann, P. R., DeMichele, A., Shatsky, R., Yee, D., Thomas, A., Nanda, R., Perlmutter, J., Heditsian, D., Hylton, N., Symmans, F., Van't Veer, L. J., Esserman, L., & Rugo, H. S. Pathologic complete response (pCR) rates for patients with HR+/HER2- high-risk, early-stage breast cancer (EBC) by clinical and molecular features in the phase II I-SPY2 clinical trial , Annals of Oncology: 2025


Li, W., Onishi, N., Gibbs, J. E., Wilmes, L. J., Le, N. N., Metanat, P., Price, E. R., Joe, B. N., Kornak, J., Yau, C., Wolf, D. M., Magbanua, M. J. M., LeStage, B., van 't Veer, L. J., DeMichele, A. M., Esserman, L. J., & Hylton, N. M. MRI-Based Model for Personalizing Neoadjuvant Treatment in Breast Cancer , Tomography: 2025


Mukhtar, R. A., Gottipati, S., Yau, C., López-Tarruella, S., Earl, H., Hayward, L., Hiller, L., Osdoit, M., van der Noordaa, M., de Croze, D., Hamy, A. S., Laé, M., Reyal, F., Sonke, G. S., Steenbruggen, T. G., van Seijen, M., Wesseling, J., Martín, M., Del Monte-Millán, M., Boughey, J. C., Goetz, M. P., Hoskin, T., Valero, V. Edge, S. B., Abraham, J. E., Bartlett, J. M. S., Caldas, C., Dunn, J., Provenzano, E., Sammut, S. J., Thomas, J. S., Graham, A., Hall, P., Mackintosh, L., Fan, F., Godwin, A. K., Schwensen, K., Sharma, P., DeMichele, A. M., Cole, K., Pusztai, L., Kim, M., van 't Veer, L. J., Cameron, D., Laura J Esserman, L. J., Fraser Symmans, W. A pooled analysis evaluating prognostic significance of Residual Cancer Burden in invasive lobular breast cancer , NPJ Breast Cancer: 2025