Description of Research Expertise

My research focuses on understanding the molecular stimuli and clinical consequences of synovial inflammation in osteoarthritis (OA) and meniscal injury. We have identified specific inflammatory pathways that are over-expressed in patients with early-stage knee OA, including Toll-like receptor pathways and chemokine-mediated pathways. We are now exploring how these pathways impact OA development and progression after joint injury in animal models, incorporating pain-related outcomes with with translational relevance. The ultimate goal of our laboratory's work is to develop novel anti-inflammatory strategies to reduce pain and disability from OA.

Selected Publications

CR Scanzello, B McKeon, BH Swaim, E DiCarlo, EU Asomugha, V Kanda, A Nair, DM Lee, JC Richmond, JN Katz, MK Crow, SR Goldring.: Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship with symptoms Arthritis & Rheumatism 63 (2): 391-400,2011.

Q Wang, AL Rozelle, CM Lepus, CR Scanzello, JJ Song, DM Larsen, JF Crish, G Bebek, SY Ritter, TM Lindstrom, I Hwang, HH Wong, L Punzi, A Encarnacion, M Shamloo, SB Goodman, T Wyss-Coray, SR Goldring, R Gobezie, MK Crow, VM Holers DM Lee, WH Robinson: Identification of a central role for complement in osteoarthritis Nature Medicine 17 (12): 1674-9,2011.

A Nair, V Kanda, C Bush-Joseph, N Verma, S Chubinskaya, K Mikecz, TT Glant, A-M Malfait, MK Crow, GT Spear, A Finnegan, CR Scanzello: Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to TLR-4 and TLR-2 ligands via soluble CD14 Arthritis & Rheumatism 64 (7): 2268-77,2012.

CR Scanzello, AS Albert, E DiCarlo, KB Rajan, V Kanda, EU Asomugha, BH Swaim, JN Katz, SR Goldring, JC Richmond, B McKeon.: The influence of synovial inflammation and hyperplasia on symptomatic outcomes up to two-years post-operatively in patients undergoing partial meniscectomy. Osteoarthritis Cartilage 21 (9): 1392-9,2013.

Nair A, Gan J, Bush-Joseph C, Verma N, Tetreault MW, Saha K, Margulis A, Fogg L, Scanzello CR.: Synovial chemokine expression and relationship with knee symptoms in patients with meniscal tears. Osteoarthritis Cartilage 23 (7): 1158-64,2015.

Sambamurthy Nisha, Nguyen Vu, Smalley Ryan, Xiao Rui, Hankenson Kurt, Gan Justin, Miller Rachel E, Malfait Anne-Marie, Dodge George R, Scanzello Carla R: Chemokine receptor-7 (CCR7) deficiency leads to delayed development of joint damage and functional deficits in a murine model of osteoarthritis. Journal of orthopaedic research 36 (3): 864-87,2018.

Sambamurthy Nisha, Zhou Cheng, Nguyen Vu, Smalley Ryan, Hankenson Kurt D, Dodge George R, Scanzello Carla R: Deficiency of the pattern-recognition receptor CD14 protects against joint pathology and functional decline in a murine model of osteoarthritis. PloS One 13 (11): e0206217,2018.

RE Miller, CR Scanzello, A-M Malfait: An Emerging Role for Toll-like Receptors at the Neuroimmune Interface in Osteoarthritis Semin Immunopathol 41 (5): 583-594,2019.

S Kolasinski, T Neogi, M Hochberg, C Oatis, GH Guyatt, J Block, L Callahan, C Copenhaver, C Dodge, D Felson, K Geller, W Harvey, G Hawker, E Herzig, K Kwoh, A Nelson, J Samuels, C Scanzello, D White, B Wise, R Altman, D DiRenzo, J Fontanarosa, G Giradi, M Ishimori, D Misra, A Shah, A Shmagel, L Thoma, M Turgunbaev, A Turner, J Reston.: 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip and Knee. Arthritis & Rheumatology 72 (2): 220-233 ,2020.

S Bansal, KD Meadows, LM Miller, KS Saleh, JM Patel, BD Stoeckl, EA Lemmon, MW Hast, MH Zgonis, CR Scanzello, DM Elliott, RL Mauck: Six Month Outcomes of Clinically Relevant Meniscal Injury in a Large Animal Model Orthopaedic Journal of Sports Medicine 9 (11): 23259671211035444,2021.

View all publications

Academic Contact Information

Division of Rheumatology
University of Pennsylvania, School of Medicine
5th Floor White Bldg
3400 Spruce Street
&
CMC VA Medical Center
3900 Woodland Ave.
Bldg 21, Rm A215
Philadelphia, PA 19104