Penn Medicine Provider
Pathology and Laboratory Medicine
Christopher D. Watt, MD, PhD
Sees patients age 18 and up
Penn Pathology and Laboratory Medicine HUP

About me

  • Associate Director, Molecular Pathology Laboratory
  • Associate Professor of Clinical Pathology and Laboratory Medicine

My clinical expertise is in Molecular Pathology.

Education and training

  • Medical School: University of Pennsylvania School of Medicine
  • Residency: Hospital of the University of Pennsylvania
  • Fellowship: Hospital of the University of Pennsylvania

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
Dr. Watt is a Penn Medicine physician.

Qualifications and experience

My research

Bakas S, Sako C, Akbari H, Bilello M, Sotiras A, Shukla G, Rudie JD, Santamaría NF, Kazerooni AF, Pati S, Rathore S, Mamourian E, Ha SM, Parker W, Doshi J, Baid U, Bergman M, Binder ZA, Verma R, Lustig RA, Desai AS, Bagley SJ, Mourelatos Z, Morrissette J, Watt CD, Brem S, Wolf RL, Melhem ER, Nasrallah MP, Mohan S, O'Rourke DM, Davatzikos C The University of Pennsylvania glioblastoma (UPenn-GBM) cohort: advanced MRI, clinical, genomics, & radiomics , Sci Data, 9(1): 2022


Nelson N, Priore S, Sondermann J, Herlihy S, Watt CD Evaluation of Positive Control Material for MGMT Promoter Methylation Studies , Journal of Molecular Diagnostics, 23(11): 2021,1618


Gentile C, Richard-Greenblatt M, Fink J, Elkan M, Harris RM, Van Deerlin VM, Glaser L, Watt CD, Herlihy SE A Practical Comparison of Seven Molecular SARS-CoV-2 Methods , The Journal of Molecular Diagnostics, 22(11): 2020,S33


Zhang Q, Orlando EJ, Wang HY, Bogusz AM, Liu X, Lacey SF, Strauser HT, Nunez-Cruz S, Nejati R, Zhang P, Brooks S, Watt CD, Melenhorst JJ, June CH, Schuster SJ, Wasik MA Transdifferentiation of lymphoma into sarcoma associated with profound reprogramming of the epigenome , Blood, 136(17): 2020,1980-1983


Herlihy SE, Carlin A, Nasrallah NP, Watt CD and Van Deerlin VM Evaluation of a Targeted Realtime Assay for Rapid Identification of IDH1 and IDH2 Disease-Associated Variants in Brain Tumors , The Journal of Molecular Diagnostics, 21(6): 2019,1201


Garces S, Nelson N, Watt CD, and Priore S FLT3 Variants Near Codon 835: An Institutional Experience Comparing Rapid Restriction Digest Testing with Massively Parallel Sequencing. , The Journal of Molecular Diagnostics, 21(6): 2019,1230


McMahon C, Ferng T, Canaani J, Wang E, Morrissette J, Eastburn D, Pellegrino M, Durruthy-Durruthy R, Watt CD, Asthana S, Lasater E, DeFilippis RA, Peretz C, McGary L, Deihimi S, Logan A, Luger S, Shah N, Carroll M, Smith C, and Perl A Clonal selection with Ras pathway activation mediates secondary clinical resistance to selective FLT3 inhibition in acute myeloid leukemia. , Cancer Discovery, 9(8): 2019,1050-1063


Brown JT, Beldorth IJ, Laosinchai-Wolf W, Fahey ME, Jefferson KL, Ruskin AK, Roth JJ, Cai L, Watt CD, Press RD, Yang F, Hedges JB, and Andruss BF Analytical validation of a highly sensitive, multiplexed chronic myeloid leukemia monitoring system targeting BCR-ABL1 RNA. , The Journal of Molecular Diagnostics, 21(4): 2019,718-733


Nasrallah MP, Binder ZA, Oldridge DA, Zhao J, Lieberman DB, Roth JJ, Watt CD, Sukhadia S, Klinman E, Daber RD, Desai A, O’Rourke DM, and Morrissette JJD Molecular neuropathology in practice: Clinical profiling and integrative analysis of molecular alterations in glioblastoma. , Academic Pathology, 6: 2019,2374289519848353


McMahon CM, Canaani J, Rea B, Sargent R, Watt CD, Morrissette JJD, Carroll M, and Perl AE Gilteritinib induces differentiation in relapsed and refractory FLT3-mutated acute myeloid leukemia. , Blood Advances, 3(10): 2019,1581-1585