Description of Research Expertise

My research interests are in the pragmatic prediction of disease and in developing systems to improve the interpretation of clinical laboratory results. Current areas of research include:

1) Leveraging electronic health record data to screen for underdiagnosed diseases, including secondary hypertension

2) Developing and implementing computational tools to improve the quality of clinical laboratory results and facilitate context-dependent interpretation

3) Improving the prediction of primary cardiovascular disease by assessing the gap between existing biomarkers and the clinical needs

Selected Publications

Lingjiao Zhang, Xiruo Ding, Yanyuan Ma, Naveen Muthu, Imran Ajmal, Jason H. Moore, Daniel S. Herman*, Jinbo Chen*; * Co-corresponding: A maximum likelihood approach to electronic health record phenotyping using positive and unlabeled patients J Am Med Inform Assoc. 27 (1): 119 - 26,2020.

Herman DS, Rhoads DD, Schulz WL, Durant TJS: Artificial Intelligence and Mapping a New Direction in Laboratory Medicine: A Review Clin Chem 67 (11) : 1466 - 82,2021.

Daniel S Herman, Eseraldo Toro, Ezra G. Baraban, Adam Bagg, Ping Wang: Falsely Increased Plasma Lactate Dehydrogenase without Hemolysis Following Transport Through Pneumatic Tube System JALM 4 (3): 433 - 38,2019.

Herman DS, Smith C, Liu C, Vaughn CP, Palaniappan S, Pritchard CC, Shirts BH: Efficient Detection of Copy Number Mutations in PMS2 Exons with Close Homologs: Detection of Copy Number Variants in 3' PMS2 Exons J Mol Diagn 20 (4): 512-521,2018.

Roberts AM*, Ware JS*, Herman DS*, Schafer S, Baksi J, Bick AG, Buchan RJ, Walsh R, John S, Wilkinson S, Mazzarotto F, Felkin LE, Gong S, MacArthur JA, Cunningham F, Flannick J, Gabriel SB, Altshuler DM, Macdonald PS, Heinig M, Keogh AM, Hayward CS, Banner NR, Pennell DJ, O'Regan DP, San TR, de Marvao A, Dawes TJ, Gulati A, Birks EJ, Yacoub MH, Radke M, Gotthardt M, Wilson JG, O'Donnell CJ, Prasad SK, Barton PJ, Fatkin D, Hubner N, Seidman JG, Seidman CE, Cook SA.: Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease. Sci Transl Med 7 (270): 270ra6,2015.

Herman DS, Ranjitkar P, Yamaguchi D, Grenache DG, Greene DN.: Endogenous alkaline phosphatase interference in cardiac troponin I and other sensitive chemiluminescence immunoassays that use alkaline phosphatase activity for signal amplification. Clin Biochem 49 (15): 1118-1121,2016.

Bick AG, Flannick J, Ito K, Cheng S, Ramachandran VS, Parfenov MG, Herman DS, DePalma SR, Gupta N, Gabriel S, Funke BH, Rehm HL, Benjamin E, Aragam J, Taylor HA, Fox ER, Newton-Cheh C, Kathiresan S, O’Donnell C, Wilson JG, Altshuler DL, Hirschhorn JN, Seidman JG, Seidman C.: Burden of rare sarcomere gene variants in the Framingham and Jackson Heart Study Cohorts. Am J Hum Gen 91 (3): 513-9,2012.

Herman DS, Lam L, Taylor MR, Wang L, Teekakirikul P, Christodoulou D, Conner L, DePalma SR, McDonough B, Sparks E, Teodorescu DL, Cirino AL, Banner NR, Pennell DJ, Graw S, Merlo M, Di Lenarda A, Sinagra G, Bos JM, Ackerman MJ, Mitchell RN, Murry CE, Lakdawala NK, Ho CY, Barton PJ, Cook SA, Mestroni L, Seidman JG, Seidman CE.: Truncations of Titin Causing Dilated Cardiomyopathy. N Engl J Med. 366 (7): 619-28,2012.

Herman DS, Hovingh GK, Iartchouk O, Rehm HL, Kucherlapati R, Seidman JG, Seidman CE.: Filter-based hybridization capture of subgenomes enables resequencing and copy-number detection. Nat Methods 6 (7): 507-10,2009.

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Academic Contact Information

3400 Spruce St. 7103 Founders Blvd.
Philadelphia, PA 19104
Phone: 215-662-6575