Description of Research Expertise

Dr. Cormode's research focuses on the development of novel and multifunctional nanoparticle contrast agents for medical imaging applications. A current major area is the development of gold and bismuth nanoparticles as contrast agents for computed tomography (CT). The nanoparticles can be further modified to have a variety of additional functional properties, such as fluorescence, MRI contrast or therapeutic effects. Related areas of interest are novel computed tomography-based imaging methods, such as dual energy CT, spectral CT and iterative image reconstruction. These technologies are being applied for structural imaging and molecular imaging of the levels of specific cell types and proteins in vivo. These approaches provide enhanced characterization of cardiovascular diseases and cancers, which should allow improved selection of therapies and monitoring of response to treatments.

Undergraduates and master's students, as well as prospective graduate students and postdoctoral fellows are encouraged to email Dr. Cormode if interested in working in our lab.

Selected Publications

Huang, Yue; Liu, Yuan; Pandey, Nil K.; Shah, Shrey; Simon-Soro, Aurea; Hsu, Jessica, C.; Ren, Zhi; Xiang, Zhenting; Kim, Dongyeop; Ito, Tatsuro; Oh, Min Jun; Buckley, Christine; Alawi, Faizan; Li, Yong; Smeets, Paul J. M.; Boyer, Sarah; Zhao, Xingchen; Joester, Derk; Zero, Domenick T.; Cormode, David P.; Koo, Hyun.: Iron oxide nanozymes stabilize stannous fluoride for targeted biofilm killing and synergistic oral disease prevention Nature Communications 14 (1): 6087,2023.

Hajfathalian, Maryam; de Vries, Christiaan R.; Hsu, Jessica C.; Amirshaghaghi, Ahmad; Dong, Yuxi C.; Ren, Zhi; Liu, Yuan; Huang, Yue; Li, Yong; Knight, Simon; Jonnalagadda, Pallavi; Zlitni, Aimen; Grice, Elizabeth; Bollyky, Paul L.; Koo, Hyun; Cormode, David P.: Theranostic gold-in-gold cage nanoparticles enable photothermal ablation and photoacoustic imaging in biofilm-associated infection models Journal of Clinical Investigation 133 (21): e168485,2023.

Hsu, Jessica C.; Tang, Zhongmin; Eremina, Olga; Sofias, Alexandros; Lammers, Twan; Lovell, Jonathan F.; Zavaleta, Cristina; Cai, Weibo; Cormode, David P.: Nanomaterial-based contrast agents Nature Reviews Methods Primers 3 (1): 30,2023.

Nieves, Lenitza M.; Dong, Yuxi C.; Rosario-Berríos, Derick N.; Mossburg, Katherine; Hsu, Jessica C.; Cramer, Gwendolyn M.; Busch, Theresa M.; Maidment, Andrew D. A.; Cormode, David P.: Renally excretable silver telluride nanoparticles as contrast agents for x-ray imaging ACS Applied Materials and Interfaces 14 (30): 34354-34364,2022.

Dong, Yuxi C.; Kumar, Ananyaa; Rosario-Berríos, Derick N.; Si-Mohamed, Salim; Hsu, Jessica C.; Nieves, Lenitza M.; Douek, Philippe; Noël, Peter B.; Cormode, David P.: Ytterbium nanoparticle contrast agents for conventional and spectral-photon counting CT and their applications for hydrogel imaging ACS Applied Materials and Interfaces 14 (34): 39274-39284,2022.

Kim, Johoon; Hong, Gwanui; Mazaleuskaya, Luda; Hsu, Jessica, C.; Rosario-Berrios, Derick N.; Grosser, Tilo; Cho-Park, Park F.; Cormode, David P.: Ultrasmall antioxidant cerium oxide nanoparticles for regulation of acute inflammation ACS Applied Materials and Interfaces 13 (51): 60852–60864,2021.

Hsu, Jessica, C.; Du, Yu; Sengupta, Arjun; Dong, Yuxi C.; Mossburg, Katherine J.; Bouché, Mathilde; Maidment, Andrew D. A.; Weljie, Aalim M.; Cormode, David P.: Effect of nanoparticle synthetic conditions on ligand coating integrity and subsequent nano-bio interactions ACS Applied Materials and Interfaces 13 (49): 58401-58410,2021.

Si-Mohamed, Salim; Sigovan, Monica; Hsu, Jessica C.; Chalabreysse, Lara; Garrivier, Thibaut; Tatard-Leitman, Valérie; Naha, Pratap C.; Carnaru, Miruna; Boussel, Loic; Cormode, David P.; Douek, Philippe.: In vivo molecular K-edge imaging of atherosclerotic plaque using photon-counting CT Radiology 300 : 98–107,2021.

Bouché, Mathilde; Sheikh, Saad; Dong, Yuxi C.; Taing, Kimberly; Saxena, Deeksha; Hsu, Jessica C.; Chen, Minna. H; Salinas, Ryan D.; Song, Hongjun; Burdick, Jason, A.; Dorsey, Jay; Cormode, David P.: Radiation-responsive hydrogel for imaging and therapeutic delivery for glioblastoma treatment ACS Biomaterials Science & Engineering 7 (7): 3209-3320,2021.

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Academic Contact Information

Hospital of the University of Pennsylvania
Department of Radiology
3400 Spruce Street, 1 Silverstein
Philadelphia, PA 19104