Penn Medicine Provider

About me

  • Cali and Weldon Research Professor in FOP
  • Professor of Orthopaedic Surgery in Genetics

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My research

Haupt, J. A. Stanley, C.M. McLeod, B.D. Cosgrove, A.L. Culbert, L. Wang, F. Mourkioti, R.L. Mauck, E.M. Shore ACVR1 R206H FOP mutation alters mechanosensing and tissue stiffness during heterotopic ossification. , Molec. Biol. Cell., 30(1): 2019,17-29


Convente, M.R., S.A. Chakkalakal, E. Yang, R.J. Caron, D. Zhang, T. Kambayashi, F.S. Kaplan, and E.M. Shore Depletion of mast cells and macrophages impairs heterotopic ossification in an Acvr1R206H mouse model of fibrodysplasia ossificans progressiva. , J. Bone Min. Res., 33: 2018,269-282


Girish Ramaswamy, Hyunsoo Kim, Deyu Zhang, Vitali Lounev, Joy Y. Wu, Yongwon Choi, Frederick S. Kaplan, Robert J. Pignolo & Eileen M. Shore. Gsα Controls Cortical Bone Quality by Regulating Osteoclast Differentiation via cAMP/PKA and β-Catenin Pathways. , Sci Rep. 7, 45140; doi: 10.1038/srep45140.: 2017


Chakkalakal, S.A., K. Uchibe, M. Convente, D. Zhang, A. Economides, F.S. Kaplan, M. Pacifici, M. Iwamoto, E.M. Shore Palovarotene inhibits heterotopic ossification and maintains limb mobility and growth in mice with the human ACVR1R206H FOP mutation. , J. Bone Min. Res. , 31: 2016,1666-1675


Culbert, A.L., S.A. Chakkalakal, E. Theosmy, T.A. Brennan, F.S. Kaplan, and E.M. Shore Alk2 regulates early chondrogenic fate in FOP heterotopic endochondral ossification. , Stem Cells, 32: 2014,1289-1300


Regard, J.B., D. Malhotra, J. Gvozdenovic-Jeremic, M. Josey, M. Chen, L.S. Weinstein, E.M. Shore, F.S. Kaplan, and Y. Yang Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification. , Nature Medicine, 19: 2013,1505-1512


Shore, E.M. and F.S. Kaplan Inherited Human Diseases of Heterotopic Bone Formation. , Nature Reviews Rheumatology , 6(9): 2010,518-527


Medici, D., E.M. Shore, V.Y. Lounev, F.S. Kaplan, R. Kalluri, and B.R. Olsen Conversion of vascular endothelial cells into multipotent stem-like cells. , Nature Medicine , 16(12): 2010,1400-1406


Shen, Q., S.C. Little, M. Xu, J. Haupt, C. Ast, T. Katagiri, S. Mundlos, P. Seemann, F.S. Kaplan, M.C. Mullins, E.M. Shore. Fibrodysplasia ossifcans progressiva ACVR1 R206H mutation activates BMP-independent chondrogenesis and ventralization of zebrafish embryos. , J. Clin. Invest, 119(11): 2009,3462-3472


Shore EM., Xu M., Feldman GJ., Fenstermacher DA., FOP International Research Consortium., Brown MA., Kaplan FS. A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva , Nature Genetics, 38(5): 2006,525-527


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