About me
- Cali and Weldon Research Professor in FOP
- Professor of Orthopaedic Surgery in Genetics
My Locations
Qualifications and experience
- Advances in Mineral Metabolism (AIMM), International
- Advisory Council, Rare Bone Disease Alliance, International
- American Association for the Advancement of Science, National
- American Society for Bone and Mineral Research, National
- American Society for Human Genetics, International
- American Society of Cell Biology (ASCB)., National
- College of Physicians, Philadelphia, PA,, Local
- European Calcified Tissue Society (ECTS), International
- European Network of Congenital Imprinting Disorders (EUCID) Consensus, International
- International Fibrodysplasia Ossificans Progressiva Association, International
- Melorheostosis Association, National
- NIH Director’s New Innovator Award Program (DP2),, National
- NIH Special Emphasis Panel ZRG1 CVRS-S (55) R, Lasker Clinical Research Scholars Program Study Section, December 3, 2019., National
- NIH/NIAMS Musculoskeletal Oral and Skin Sciences (MOSS), ZRG1 MOSS-F (02);, National
- Progressive Osseous Heteroplasia Association, National
- Rare Bone Disease Alliance Scientific Advisory Panel, National
- Reviewer, NIH Director’s New Innovator Award Program, December, 2022 and December, 2023, National
- Reviewer, NIH Director’s New Innovator Award Program, December, 2023, National
- University of Arkansas for Medical Sciences Centers of Biomedical Research Excellence (COBRE, P20-GM125503) External Advisory Committee., National
Treatments and Conditions
My research
Haupt, J. A. Stanley, C.M. McLeod, B.D. Cosgrove, A.L. Culbert, L. Wang, F. Mourkioti, R.L. Mauck, E.M. Shore ACVR1 R206H FOP mutation alters mechanosensing and tissue stiffness during heterotopic ossification. , Molec. Biol. Cell., 30(1): 2019,17-29
Convente, M.R., S.A. Chakkalakal, E. Yang, R.J. Caron, D. Zhang, T. Kambayashi, F.S. Kaplan, and E.M. Shore Depletion of mast cells and macrophages impairs heterotopic ossification in an Acvr1R206H mouse model of fibrodysplasia ossificans progressiva. , J. Bone Min. Res., 33: 2018,269-282
Girish Ramaswamy, Hyunsoo Kim, Deyu Zhang, Vitali Lounev, Joy Y. Wu, Yongwon Choi, Frederick S. Kaplan, Robert J. Pignolo & Eileen M. Shore. Gsα Controls Cortical Bone Quality by Regulating Osteoclast Differentiation via cAMP/PKA and β-Catenin Pathways. , Sci Rep. 7, 45140; doi: 10.1038/srep45140.: 2017
Chakkalakal, S.A., K. Uchibe, M. Convente, D. Zhang, A. Economides, F.S. Kaplan, M. Pacifici, M. Iwamoto, E.M. Shore Palovarotene inhibits heterotopic ossification and maintains limb mobility and growth in mice with the human ACVR1R206H FOP mutation. , J. Bone Min. Res. , 31: 2016,1666-1675
Culbert, A.L., S.A. Chakkalakal, E. Theosmy, T.A. Brennan, F.S. Kaplan, and E.M. Shore Alk2 regulates early chondrogenic fate in FOP heterotopic endochondral ossification. , Stem Cells, 32: 2014,1289-1300
Regard, J.B., D. Malhotra, J. Gvozdenovic-Jeremic, M. Josey, M. Chen, L.S. Weinstein, E.M. Shore, F.S. Kaplan, and Y. Yang Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification. , Nature Medicine, 19: 2013,1505-1512
Shore, E.M. and F.S. Kaplan Inherited Human Diseases of Heterotopic Bone Formation. , Nature Reviews Rheumatology , 6(9): 2010,518-527
Medici, D., E.M. Shore, V.Y. Lounev, F.S. Kaplan, R. Kalluri, and B.R. Olsen Conversion of vascular endothelial cells into multipotent stem-like cells. , Nature Medicine , 16(12): 2010,1400-1406
Shen, Q., S.C. Little, M. Xu, J. Haupt, C. Ast, T. Katagiri, S. Mundlos, P. Seemann, F.S. Kaplan, M.C. Mullins, E.M. Shore. Fibrodysplasia ossifcans progressiva ACVR1 R206H mutation activates BMP-independent chondrogenesis and ventralization of zebrafish embryos. , J. Clin. Invest, 119(11): 2009,3462-3472
Shore EM., Xu M., Feldman GJ., Fenstermacher DA., FOP International Research Consortium., Brown MA., Kaplan FS. A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva , Nature Genetics, 38(5): 2006,525-527