Description of Research Expertise
Keywords: muscle stem cells, stem cell activation, muscle disorders, mechanobiology, aging, telomeres, NF-kB signaling, muscle regeneration, stem cell regulation, muscular dystrophy, cardiomyopathy, mitochondria, oxidative stress, M2 macrophages, muscle atrophy, muscle wasting.
Selected Publications
Das S, Hilman MC, Yang F, Mourkioti F, Yang W, Cullen DK.: Motor neurons and endothelial cells additively promote development and fusion of human iPSC-derived skeletal myocytes Skeletal Muscle 7 (14): 2024.
Ma N., Mourkioti F: Ex vivo two-photon imaging of whole-mount skeletal muscles to visualize stem cell behavior STAR Protocols 5 (1): 1-14,2023.
Tichy ED, Lee JH, Li G, Estep KN, Johnson FB, Mourkioti F.: Impacts of radiation exposure, hindlimb unloading, and recovery on murine skeletal muscle cell telomere length NPJ Microgravity : 2023.
Bautista C.A., Srikumar A., Tichy E.D., Qian G., Jiang X., Qin L., Mourkioti F., Dyment N. CD206: CD206+ tendon resident macrophages and potential crosstalk with fibroblasts and the ECM during tendon growth and maturation. Front. Physiol., Sec. Skeletal Physiology 14 : 2023.
Ma N., Chen D., Lee, J.H., Kuri P., Hernandez E.B., Kocan B., Mahmood H., Tichy E.D., Rompolas P., Mourkioti F.: Piezo1 regulates the regenerative capacity of skeletal muscles via orchestration of stem cell morphological states Science Advances 8 (11): 1-14,2022.
Stanley A, Tichy ED, Kocan J, Roberts DW, Shore EM and Mourkioti F.: Dynamics of skeletal muscle-resident stem cells during myogenesis in fibrodysplasia ossificans progressiva
NPJ Regenerative Medicine-Nature 7 (1): 2022.
Tichy ED, Mourkioti F.: Telomere length assessments of muscle stem cells in rodent and human skeletal muscle sections STAR Protoc 2 (4): 2021.
Tichy ED, Ma N., Sidibe D., Loro E., Kocan J., Chen DZ., Khurana TS., Hasty P., Mourkioti F.: Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shortening Cell Reports 35 (6): 2021.
Lutian Yao, Elisia D. Tichy, Leilei Zhong, Sarthak Mohanty, Luqiang Wang, Emily Ai, Shuying Yang, Foteini Mourkioti1*, Ling Qin *: Gli1 defines a subset of fibroadipogenic progenitors that promote skeletal muscle regeneration with less fat accumulation Journal of Bone and Mineral Research 36 (6): 1159-1173,2021.
Suradip Das, Kevin D. Browne, Franco A. Laimo, Joseph C. Maggiore, Melanie C. Hilman, , Halimulati Kaisaier, Carlos A. Aguilar, Zarina S. Ali, Foteini Mourkioti, D. Kacy Cullen: Pre-Innervated Tissue Engineeried Muscle Promotes a Pro-Regenerative Microenvironment Following Volumetric Muscle Loss Communications Biology-Nature 3 (1): 2020.
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Academic Contact Information
McKay Orthopaedic Research Laboratory
377A Stemmler Hall
3450 Hamilton Walk
Philadelphia,
PA
19104-6081
Phone: 215-898-8214