Description of Research Expertise

Keywords: muscle stem cells, stem cell activation, muscle disorders, mechanobiology, aging, telomeres, NF-kB signaling, muscle regeneration, stem cell regulation, muscular dystrophy, cardiomyopathy, mitochondria, oxidative stress, M2 macrophages, muscle atrophy, muscle wasting.

Selected Publications

Ma N., Mourkioti F: Ex vivo two-photon imaging of whole-mount skeletal muscles to visualize stem cell behavior STAR Protocols 5 (1): 1-14,2024.

Das S, Hilman MC, Yang F, Mourkioti F, Yang W, Cullen DK.: Motor neurons and endothelial cells additively promote development and fusion of human iPSC-derived skeletal myocytes Skeletal Muscle 7 (14): 2024.

Tichy ED, Lee JH, Li G, Estep KN, Johnson FB, Mourkioti F.: Impacts of radiation exposure, hindlimb unloading, and recovery on murine skeletal muscle cell telomere length NPJ Microgravity 15 (9): 76,2023.

Bautista C.A., Srikumar A., Tichy E.D., Qian G., Jiang X., Qin L., Mourkioti F., Dyment N. CD206: CD206+ tendon resident macrophages and potential crosstalk with fibroblasts and the ECM during tendon growth and maturation. Front. Physiol., Sec. Skeletal Physiology 14 : 2023.

Ma N., Chen D., Lee, J.H., Kuri P., Hernandez E.B., Kocan B., Mahmood H., Tichy E.D., Rompolas P., Mourkioti F.: Piezo1 regulates the regenerative capacity of skeletal muscles via orchestration of stem cell morphological states Science Advances 8 (11): 1-14,2022.

Stanley A, Tichy ED, Kocan J, Roberts DW, Shore EM and Mourkioti F.: Dynamics of skeletal muscle-resident stem cells during myogenesis in fibrodysplasia ossificans progressiva NPJ Regenerative Medicine-Nature 7 (1): 2022.

Tichy ED, Mourkioti F.: Telomere length assessments of muscle stem cells in rodent and human skeletal muscle sections STAR Protoc 2 (4): 2021.

Tichy ED, Ma N., Sidibe D., Loro E., Kocan J., Chen DZ., Khurana TS., Hasty P., Mourkioti F.: Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shortening Cell Reports 35 (6): 2021.

Lutian Yao, Elisia D. Tichy, Leilei Zhong, Sarthak Mohanty, Luqiang Wang, Emily Ai, Shuying Yang, Foteini Mourkioti1*, Ling Qin *: Gli1 defines a subset of fibroadipogenic progenitors that promote skeletal muscle regeneration with less fat accumulation Journal of Bone and Mineral Research 36 (6): 1159-1173,2021.

Suradip Das, Kevin D. Browne, Franco A. Laimo, Joseph C. Maggiore, Melanie C. Hilman, , Halimulati Kaisaier, Carlos A. Aguilar, Zarina S. Ali, Foteini Mourkioti, D. Kacy Cullen: Pre-Innervated Tissue Engineeried Muscle Promotes a Pro-Regenerative Microenvironment Following Volumetric Muscle Loss Communications Biology-Nature 3 (1): 2020.

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Academic Contact Information

McKay Orthopaedic Research Laboratory
377A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104-6081
Phone: 215-898-8214