Description of Research Expertise

Electrophysiology of the human atria and ventricles
Mechanism of supraventricular and ventricular arrhythmias
Anatomic and electrophysiologic substrate of atrial and ventricular arrhythmias.
Catheter ablative therapy in atrial and ventricular arrhythmias
Device therapy in management of ventricular arrhythmias
Arrhythmogenic cardiomyopathy and cardiac arrhythmias

Selected Publications

Shirai Y, Liang JJ, Santangeli P, Supple GE, Riley MP, Garcia FC, Lin D, Dixit S, Callans DJ, Marchlinski FE, Frankel DS, Schaller RD: Catheter Ablation of Premature Ventricular Complexes with Low Intraprocedural Burden Guided Exclusively by Pace-mapping J Cardiovasc Electrophysio 30 (11): 2326,2019.

Kodali S, Shirai Y, Muser D, Callans DJ, Marchlinski FE, Santangeli P: Ventricular Tachycardia in Nonischemic Cardiomyopathy:Anteroseptal Versus Inferolateral Origin Based On ICD Ventricular Electrogram Timing J Cardiovasc Electrophysiol 30 (11): 2334-2343,2019.

Maheshwari A, Shirai Y, Hyman MC, Arkles JS, Santangeli P, Schaller RD, Supple GE, Nazarian S, Lin D, Dixit S, Callans DJ, Marchlinski FE, Frankel DS: Septal Versus Mitral Isthmus Ablation for Treatment of Mitral Annular Flutter JACC Clin Electrophysiol : 2019.

Ustunkaya T, Desjardins B, Wedan R, Chahal CAA, Zimmerman SL, Saju N, Zahid S, Sharma A, Han Y, Trayanova N, Marchlinski FE, Calkins H, Tandri H, Nazarian S.: Epicardial Conduction Speed, Electrogram Abnormality, and Computed Tomography Attenuation Associations in Arrhythmogenic Right Ventricular Cardiomyopathy JACC Clin Electrophysio 5 (10): 1158,2019.

Briceño DF, Liang JJ, Shirai Y Markman TM, Enriquez A, Lin A, Santangeli P, Riley MP, Schaller RD, Nazarian S, Lin D, Kumareswaran R, Arkles JS, Hyman MC, Supple GE, Frankel DS, Garcia FC, Callans DJ, Marchlinski FE, , Dixit S.: Clinical and Electrophysiological Characteristics of Idiopathic Ventricular Arrhythmias Originating from the Slow Pathway Region Heart Rhythm 16 (9): 142,2019.

Kuo L, Shirai Y, Muser D, Liang JJ, Castro SA, Santangeli P, Schaller RD, Supple GE, Lin D, Nazarian S, Dixit S, Callans DJ, Marchlinski FE, Frankel DS.: Comparison of the Arrhythmogenic Substrate Between Men and Women with Nonischemic Cardiomyopathy Heart Rhythm 16 (9): 141,2019.

Kodali S, Shirai Y, Callans DJ, Zado ES, Marchlinski FE, Santangeli P: Usefulness of ICD Electrograms Analysis to Distinguish Endocardial Versus Epicardial Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy. J Cardiovasc Electrophysiol 30 (9): 1526,2019.

Yang J, Brunnquell M, Liang JJ, Callans DJ, Garcia FC, Lin D, Frankel DS, Kay J, Marchlinski FE, Tzou W, Sauer WH, Liu B, Ruckdeschel ES, Collins K, Santangeli P, Nguyen DT.: Long term Follow-up after Ventricular Tachycardia Ablation in Patients with Congenital Heart Disease J Cardiovasc Electrophysiol 30 (9): 1560,2019.

Zielonka B, Kim YY, Supple GE, Partington SL, Ruckdeschel ES, Marchlinski FE, Frankel DS: Improvement in Ventricular Function with Rhythm Control of Atrial Arrhythmias May Delay the Need for Atrioventricular Valve Surgery in Adults with Congenital Heart Disease Congenit Heart Dis : 2019.

566., Boersma LV, Natale A, Haines D, DeLurgio D, Sood N, Marchlinski F, Calkins H, Hoyt RH, Sanders P, Irwin J, Packer D, Mittal S, Durrani S, DiBiase L, Sangrigoli R, Tada H, Sasano T, Tomita H, Yamane T, Kuck KH, Wazni O, Tarakji K, Cerkvenik J, van Bragt KA, Abeln BGS, Verma A.: Prevalence, timing, and impact of early recurrence of atrial tachyarrhythmias after pulsed field ablation: A secondary analysis of the PULSED AF trial. Heart Rhythm : 2024.

Chaumont C, Tschabrunn CM, Oraii A, Zado ES, Yogasundaram H, Sekigawa M, Markman T, Deo R, Dixit S, Epstein AE, Garcia FC, Lin D, Riley MP, Supple GE, Hyman MC, Nazarian S, Callans DJ, Anselme F, Frankel DS, Marchlinski FE.: Long-term freedom from ventricular arrhythmias in ARVC with endocardial only ablation: origin, and ablation outcomes of ventricular premature depolarizations initiating ventricular fibrillation. Heart Rhythm : 2024.

Marchlinski FE, Oraii A, Muser D.: "Anticoagulation for atrial fibrillation in patients with intermediate stroke risk: is the grey zone becoming less grey?" Eur Heart J 45 (1): 67-69,2024.

Thind M, Oraii A, Chaumont C, Arceluz MR, Sekigawa M, Yogasundaram H, Sugrue A, Mirwais M, AlSalem AB, Zado ES, Guandalini GS, Markman TM, Deo R, Schaller RD, Dixit S, Epstein AE, Supple GE, Tschabrunn CM, Santangeli P, Callans DJ, Hyman MC, Nazarian S, Frankel DS, Marchlinski FE: Predictors of Non-Pulmonary vein triggers for atrial fibrillation: A clinical risk score. Heart Rhythm (24): 2024.

marrouche NF, Wazni O, McGann C, Greene T, Dean JM, Dagher L, Kholmovski E, Mansour M, Marchlinski F, Wilber D, Hindricks G, Mahnkopf C, Wells D, Jais P, Sanders P, Brachmann J, Bax JJ, Morrison-de Boer L, Deneke T, Calkins H, Sohns C, Akoum N;: Effect of MRI-Guided Fibrosis Ablation vs Conventional Catheter Ablation on Atrial Arrhythmia Recurrence in Patients With Persistent A-Fib: The DECAAF II. Randomized Clinical Trial. J JAMA : 2022.

Thind M, Arceluz MR, Lucena-Padros I, Kubala M, Mirwais M, Bode W, Cerantola M, Sugrue A, Van Niekerk C, Vigdor A, Patel NA, AlSalem AB, Zado ES, Kumareswaran R, Lin D, Arkles JS, Garcia FC, Guandalini GS, Markman TM, Riley MP, Deo R, Schaller RD, Nazarian S, Dixit S, Epstein AE, Supple GE, Frankel DS, Tschabrunn CM, Santangeli P, Callans DJ, Hyman MC, Marchlinski FE: Identifying Origin of Nonpulmonary Vein Triggers Using 2 Stationary Linear Decapolar Catheters: A Novel Algorithm JACC Clin Electrophysiol : 2023.

Arceluz MR, Liuba I, Tschabrunn CM, Frankel DS, Santangeli P, Supple GS, Schaller RD, Garcia FC, Callans DJ, Guandalini Gustavos S. Walsh K, Nazarian S, Zado ES, Marchlinski FE.: "Sinus Rhythm QRS Amplitude and Fractionation in Patients with Non-Ischemic Cardiomyopathy to Identify Ventricular Tachycardia Substrate and Location" Heart Rhythm 19 (2): 187-194,2022.

Marrouche NF, Wazni O, McGann C, Greene T, Dean JM, Dagher L, Kholmovski KE, Mansour M, Marchlinski FE, Wilber D, Hendricks G, Mahnkopf C, Wells D, Jais P, Sanders P, Brachmann J, Bax JJ, Morrison-de Boer L, Deneke T, Calkins H, Sohns C, Akoum N: DECAAF-II investigators: Effect of MRI-guided fibrosis ablation vs conventional catheter ablation on atrial arrhythmia recurrence in patients with persistent A-fib: The DECAAF II Randomized Clinical Trial. JAMA 21;327 (23): 2296-2305,2022.

Shirai Y, Liang JJ, Santangeli P, Supple GE, Riley MP, Garcia FC, Lin D, Dixit S, Callans DJ, Marchlinski FE, Frankel DS, Schaller RD: Catheter Ablation of Premature Ventricular Complexes with Low Intraprocedural Burden Guided Exclusively by Pace-mapping J Cardiovasc Electrophysiol : 2019.

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Academic Contact Information

The Pavilion
One Convention Avenue
2 Pavilion - City Side
Electrophysiology Suite

Philadelphia, PA 19104-4283
Phone: 215-662-6005
Patient appointments: 800-789-7366