Penn Medicine Provider
Pulmonary Medicine
George L. Anesi, MD, MSCE, MBE
Accepting new patients
Sees patients age 18 and up
Harron Lung Center - Inpatient Care

About me

  • Director, Medical Critical Care Bioresponse Program, and Medical Director, Special Pathogen Treatment Unit, Hospital of the University of Pennsylvania
  • Co-Chair, Penn Medicine Critical Care Alliance COVID-19 and Pandemic Preparedness Committee
  • Assistant Professor of Medicine (Pulmonary, Allergy and Critical Care) at the Hospital of the University of Pennsylvania

I am an Assistant Professor of Medicine at the University of Pennsylvania's Perelman School of Medicine and an Attending Physician in Pulmonary and Critical Care Medicine at the Hospital of the University of Pennsylvania. I have advanced training in health services research, clinical epidemiology, high-risk pathogen and disaster preparedness, biomedical ethics, and global health.

My NIH-funded research program focuses on hospital preparedness and the evaluation of critical care and acute care resources during times of strain to the system, including situations of dynamic strain (e.g., random variation in demand, seasonal trends, epidemics, and disasters) and fixed strain (e.g., critical illness in resource-limited settings domestically and globally).

I received my undergraduate degree from the University of Chicago and MD from Case Western Reserve University School of Medicine. I completed my internal medicine residency at Massachusetts General Hospital and fellowship in pulmonary and critical care medicine at Penn. I also hold masters degrees in clinical epidemiology from Penn and bioethics from Case Western.

At Penn, I see patients in the medical intensive care units (ICUs) and on the Rapid Response service. I serve as Director of the Medical Critical Care Bioresponse Program, Medical Director of the Special Pathogen Treatment Unit, and Co-Chair of the Penn Medicine Critical Care Alliance COVID-19 and Pandemic Preparedness Committee.

Education and training

  • Medical School: Case Western Reserve University School of Medicine
  • Residency: Massachusetts General Hospital
  • Fellowship: Hospital of the University of Pennsylvania

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital: Has privileges to treat patients in the hospital.
Dr. Anesi is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Anesi GL Approach to Hospital Preparedness for Acute Surge Events Due to Emerging Infectious Diseases , JAMA, 332(18): 2024


Anesi GL, Savarimuthu SM, Invernizzi J, Hyman R, Ramkillawan A, Eddey C, Wise RD, Smith MTD ICU Mortality Across Prepandemic and Pandemic Cohorts in a Resource-Limited Setting: A Critical Care Resiliency Analysis From South Africa , CHEST Critical Care, 1(1): 2023,100005


Anesi GL, Degnan K, Dutcher L, Saw S, Maguire C, Binkley A, Patel S, Athans V, Barton TD, Binkley S, Candeloro CL, Herman DJ, Kasbekar N, Kennedy L, Millstein JH, Meyer NJ, Talati NJ, Patel H, Pegues DA, Sayre PJ, Tebas P, Terico AT, Murphy KM, O’Donnell JA, White M, Hamilton KW The Penn Medicine COVID-19 Therapeutics Committee—Reflections on a Model for Rapid Evidence Review and Dynamic Practice Recommendations During a Public Health Emergency , Open Forum Infect Dis, 10(8): 2023,ofad428


Anesi GL, Andrews A, Bai H, Bhatraju PK, Brett-Major DM, Broadhurst MJ, Campbell ES, Cobb JP, Gonzalez M, Homami S, Hypes CD, Irwin A, Kratochvil CJ, Krolikowski K, Kumar VK, Landsittel D, Lee RA, Liebler JM, Lutrick K, Marts LT, Mosier JM, Mukherjee V, Postelnicu R, Rodina V, Segal LN, Sevransky JE, Spainhour C, Srivastava A, Uyeki TM, Wurfel MM, Wyles D, Evans L for the Severe Acute Respiratory Infection – Preparedness (SARI-PREP) Study Group Perceived Hospital Stress, Severe Acute Respiratory Syndrome Coronavirus 2 Activity, and Care Process Temporal Variance During the COVID-19 Pandemic , Crit Care Med, 51(4): 2023,445-459


Anesi GL, Dress E, Chowdhury M, Wang W, Small DS, Delgado MK, Bayes B, Barreda FX, Halpern SD, Liu VX Hospital Strain and Variation in Sepsis ICU Admission Practices and Associated Outcomes , Crit Care Explor, 4(2): 2023,e0858


Anesi GL, Xiong R, Delgado MK Frequency and Trends of Pre-Pandemic Surge Periods in U.S. Emergency Departments, 2006–2019 , Crit Care Explor, 5(8): 2023,e1023


Anesi GL, Dress E, Chowdhury M, Wang W, Small DS, Delgado MK, Bayes B, Szymczak JE, Glassman LW, Barreda FX, Weiner JZ, Escobar GJ, Halpern SD, Liu VX Among-Hospital Variation in ICU Admission Practices and Associated Outcomes for Patients with Acute Respiratory Failure , Ann Am Thorac Soc, 20(3): 2023,406-413


Anesi GL, Liu VX, Chowdhury M, Small DS, Wang W, Delgado MK, Bayes B, Dress E, Escobar GJ, Halpern SD Association of Intensive Care Unit Admission and Outcomes in Sepsis and Acute Respiratory Failure , Am J Respir Crit Care Med, 205(5): 2022,520-528


Anesi GL, Jablonski J, Harhay MO, Atkins JH, Bajaj J, Baston C, Brennan PJ, Candeloro CL, Catalano LM, Cereda MF, Chandler JM, Christie JD, Collins T, Courtright KR, Fuchs BD, Gordon E, Greenwood JC, Gudowski S, Hanish A, Hanson CW, Heuer M, Kinniry P, Kornfield ZN, Kruse GB, Lane-Fall M, Martin ND, Mikkelsen ME, Negoianu D, Pascual JL, Patel MB, Pugliese SC, Qasim ZA, Reilly JP, Salmon J, Schweickert WD, Scott MJ, Shashaty MGS, Sicoutris CP, Wang JK, Wani AA, Anderson BJ, Gutsche JT Characteristics, Outcomes, and Trends of Patients With COVID-19–Related Critical Illness at a Learning Health System in the United States , Ann Intern Med, 174(5): 2021,613-621


Anesi GL, Chowdhury M, Small DS, Delgado MK, Kohn R, Bayes B, Wang W, Dress E, Escobar GJ, Halpern SD, Liu VX Association of a Novel Index of Hospital Capacity Strain on Admission to Intensive Care Units , Ann Am Thorac Soc, 17(11): 2020,1440-1447


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