Description of Research Expertise
Dr. Brotman's research focuses on advanced hemodynamic monitoring and dialysis techniques for acute kidney injury and chronic kidney disease. She has a broad background in biomedical engineering and epidemiology, with specific training in hierarchical modeling of longitudinal data and incorporation of advanced technology into clinical application. She has worked on various translational projects, including mathematical models for tumor growth, functional imaging, alternative serum biomarkers to guide clinical diagnostic and treatment decisions, and use of machine learning algorithms to assess the risk of acute kidney injury. She developed a novel method to quantify a semi-instantaneous rate of vascular refilling that could be monitored continuously throughout hemodialysis and studied its association with circulatory instability during hemodialysis treatments. This work has laid the foundation for a line of inquiry in the use of advanced monitoring techniques to improve the precision and tolerance of fluid removal during hemodialysis. She is currently studying the acute impacts of hemodialysis on various areas of systemic and local perfusion, including changes in blood pressure, plasma refill, and cardiac and cerebral perfusion and function. Her work has been funded by the National Institute of Health (NIH) and Industry-sponsored grants.
Selected Publications
Wang, Christina H.; Negoianu, Dan; Zhang, Hanjie; Casper, Sabrina; Hsu, Jesse Y.; Kotanko, Peter; Raimann, Jochen; Dember, Laura M.: Dynamics of Plasma Refill Rate and Intradialytic Hypotension During Hemodialysis: Retrospective Cohort Study With Causal Methodology Kidney 360 4 (4): e505-e514,2023.
Wang, Christina H.; Fay, Kevin; Shashaty, Michael G.S.; Negoianu, Dan: Volume Management with Kidney Replacement Therapy in the Critically Ill Patient Clinical Journal of the American Society of Nephrology (CJASN) : 2023.
Wang, CH: Variability of Plasma Refill Rate and Risk of Intradialytic Hypotension During Maintenance Hemodialysis. Poster Presentation, The American Society of Nephrology Kidney Week (Virtual) : 2021.
Wang, CH: Plasma Refill Rate: A Potential Hemodynamic Marker of Intradialytic Hypotension during Hemodialysis Poster Presentation, American Society of Nephrology Kidney Week (Virtual) : 2021.
Wang, CH: Dynamics of Plasma Refill Rate and Intradialytic Hypotension during Hemodialysis. Oral Presentation, National Kidney Foundation Young Investigators Forum (Virtual) : 2021.
Wang, CH: Plasma Refill Rate and Intradialytic Hypotension during Hemodialysis Poster Presentation, Department of Medicine Research Day, The Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA : 2020.
Wang, CH: Plasma Refill Rate and Intradialytic Hypotension during Hemodialysis Oral Presentation, Mid-Atlantic Young Investigators Forum, Baltimore, MD : 2020.
Wang CH, Hogan JJ.: Monoclonal Gammopathies and Kidney Disease: Searching for Significance Clin J Am Soc Nephrol 13 : 1781-1782,2018.
Wang CH, Rubinsky AD, Minichiello T, Shlipak MG, Price EL.: Creatinine Versus Cystatin C: Differing Estimates of Renal Function in Hospitalized Veterans Receiving Anticoagulants J Gen Intern Med : 2018.
Wang, CH: Creatinine Versus Cystatin C: Differing Estimates of Renal Function in Hospitalized Veterans Receiving Anticoagulants Oral Presentation, California-Hawaii SGIM, UCLA, Los Angeles, CA : 2017.
Academic Contact Information
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Patient appointments: 800-789-7366