Selected Publications
Jiang B, Liang S, Liang G, Wei H: Could dantrolene be explored as a repurposed drug to treat COVID-19 patients by restoring intracellular calcium homeostasis? European Review for Medical and Pharmacological Sciences
88 : 28-29,2020.
Jiang B, Wei H: Oxygen therapy strategies and techniques to treat hypoxia in COVID-19 patients European Review for Medical and Pharmacological Sciences
24 (19): 10239-10246,2020.
Wang J, Shi Y, Yu S, Wang Y, Meng Q, Liang G, Eckenhoff MF, Wei H: Intranasal administration of dantrolene increased brain concentration and duration PloS one 15 (3): e0229156,2020.
Yun Shi, Lei Zhang, Xue Gao, Jing Zhang, Matan Ben Abou, Ge Liang, Qingcheng Meng, Adrian Hepner, Maryellen F. Eckenhoff, Huafeng Wei: Intranasal Dantrolene as a Disease-Modifying Drug in Alzheimer 5XFAD Mice Journal of Alzheimer's Disease 76 (4): 1375-1389,2020.
WEI H: New Approaches to Develop Drug Treatment for Alzheimer’s Disease: Targeting Calcium Dysregulation Current Alzheimer Research 17 (4): 311-312,2020.
Matan Ben Abou, Liang Sun, and Huafeng Wei: Approaches to Optimizing Dantrolene Neuroprotection for the Treatment of Alzheimer's Disease Current Alzheimer Research 17 (4): 324-328,2020.
Wang Y, Liang G, Liang S, Mund R, Shi Y, Wei H: Dantrolene Ameliorates Impaired Neurogenesis and Synaptogenesis in Induced Pluripotent Stem Cell Lines Derived from Patients with Alzheimer's Disease Anesthesiology 132 (5): 1062-1079,2020.
Wei H, Jiang B, Behringer EC, Hofmeyer R, Myatra SN, Wong DT, O’ Sullivan E, Hagberg CA, McGuire B, Paker P, Li, J, Pylypenko M, Ma W, Zuo M, Senturk NM, Klein U: Controversial Topics Regarding Airway Management in COVID-19 Patients: Updated Information and International Expert Opinion British Journal of Anaesthesia 126 (361-366): 2021.
Deng X, Vipani M, Liang G, Gouda D, Wang B, Wei H: Sevoflurane modulates breast cancer cell survival via modulation of intracellular calcium homeostasis BMC Anesthesiology 20 : 253,2020.
Liang S, Liang G, Li Y, Wei H.: Dantrolene ameliorate glutamate induced cytosolic and mitochondrial calcium increase in iPSCs derived neurons from AD patients
Annual Meeting of American Society of Anesthesiologists (ASA) : 2020.
Qiaoyun L, Ping X, Benjun Z, ZhiYun W, Wei H: Supraglottic jet oxygenation and ventilation saved a patient with 'cannot intubate and cannot ventilate' emergency difficult airway J Anesth 31 (1): 144-147,2017.
Yang M, Wei H: Anesthetic neurotoxicity: Apoptosis and autophagic cell death mediated by calcium dysregulation Neurotoxicol Teratol. 60 : 59-62,2017.
Ren G, Zhou Y, Liang G, Yang B, Yang M, King A, Wei H: General Anesthetics Regulate Autophagy via Modulating the Inositol 1,4,5-Trisphosphate Receptor: Implications for Dual Effects of Cytoprotection and Cytotoxicity Sci Rep 7 (1): 12378,2017.
Wang Y, Shi Y, Wei H: Calcium Dysregulation in Alzheimer's Disease: A Target for New Drug Development. J Alzheimers Dis Parkinsonism 7 (5): 2017.
Shi Y, Wang Y, Wei H: Dantrolene : From Malignant Hyperthermia to Alzheimer's Disease CNS Neurol Disord Drug Targets 18 (9): 668-676,2019.
Berger M, Schenning KJ, Brown CH, Deiner SG, Whittington RA, Eckenhoff RG, Angst MS, Avramescu S, Bekker A, Brzezinski M, Crosby G, Culley DJ, Eckenhoff M, Eriksson LI, Evered L, Ibinson J, Kline RP, Kofke A, Ma D, Mathew JP, Maze M, Orser BA, Price CC, Scott DA, Silbert B, Su D, Terrando N, Wang DS, Wei H, Xie Z, Zuo Z: Best Practices for Postoperative Brain Health: Recommendations From the Fifth International Perioperative Neurotoxicity Working Group Anesth Analg 127 (6): 1406-1413,2018.
Yang M, Wang Y, Liang G, Xu Z, Chu CT, Wei H: Alzheimer's Disease Presenilin-1 Mutation Sensitizes Neurons to Impaired Autophagy Flux and Propofol Neurotoxicity: Role of Calcium Dysregulation. J Alzheimers Dis 67 (1): 137-147,2019.
Liang H, Hou Y, Wei H, Feng Y: Supraglottic jet oxygenation and ventilation assisted fiberoptic intubation in a paralyzed patient with morbid obesity and obstructive sleep apnea: a case report BMC Anesthesiol 19 (1): 40,2019.
Hou Y, Liang H, Wei H, Feng Y: WEI nasal jet tube during monitored anaesthesia care for removal of oesophageal foreign body for a patient with fragile cardiopulmonary function Indian J Anaesth 63 (5): 403-405,2019.
Liang H, Hou Y, Sun L, Li Q, Wei H, Feng Y: Supraglottic jet oxygenation and ventilation for obese patients under intravenous anesthesia during hysteroscopy: a randomized controlled clinical trial. BMC Anesthesiol 19 (1): 151,2019.
Joseph DJ, Liu C, Peng J, Liang G, Wei H: Isoflurane mediated neuropathological and cognitive impairments in the triple transgenic Alzheimer's mouse model are associated with hippocampal synaptic deficits in an age-dependent manner PloS one 14 (10): e0223509,2019.
Eckenhoff RG, Maze M, Xie Z, Culley DJ, Goodlin SJ, Zuo Z, Wei H, Whittington RA, Terrando N, Orser BA, Eckenhoff MF: Perioperative Neurocognitive Disorder: State of the Preclinical Science Anesthesiology 132 (1): 55-68,2020.
Yao W, Wang T, Jiang B, Gao F, Wang L, Zheng H, Xiao W, Yao Shanglong, Mei W, Chen X, Luo A, Sun L, Cook T, Behringer E, Huitink JM, Wong DT, Lane-Fall M, McNarry AF, McGuire B, Higgs A, Shah A, Patel A, Zuo M, Ma W, Xue Z, Zhang LM, Li W, Wang Y, Hagberg C, O'Sullivan EP, Fleisher LA, Wei H: Emergency tracheal intubation in 202 patients with COVID-19 in Wuhan, China: lessons learnt and international expert recommendations British Journal of Anaesthesia 125 (1): e28-e37,2020.
Xu Z, Wang Y, Liang G, Liu Z, Ma W, Chu CT, Wei H: Propofol affects mouse embryonic fibroblast survival and proliferation in vitro via ATG5- and calcium-dependent regulation of autophagy Acta Pharmacol Sin 41 (3): 303-310,2020.
Xu Z, Liu Z, Zhang Y, Jin C, Shen F, Yu Y, Cheek T, Onuoha O, Liang G, Month R, Atkins J, Tran KM, Wei H: S100β in newborns after C-section with general vs. epidural anesthesia: a prospective observational study Acta Anaesthesiol Scand 62 (3): 293-303,2018.
Qin Y, Li LZ, Zhang XQ, Wei Y, Wang YL, Wei HF, Wang XR, Yu WF, Su DS: Supraglottic jet oxygenation and ventilation enhances oxygenation during upper-gastrointestinal endoscopy in patients sedated with propofol: A randomized multicentre clinical trial British Journal of Anaesthesia 119 (1): 158-66,2017.
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Academic Contact Information
Department of Anesthesiology and Critical Care Medicine
University of Pennsylvania
305 John Morgan Building
3620 Hamilton Walk
Email: huafeng.wei@pennmedicine.upenn.edu
Philadelphia,
PA
19104-6112
Phone: 215-260-9840