Description of Research Expertise
Optical imaging of endogenous and/or exogenous fluorescence for the following research interests:
1) Identification of optical redox imaging biomarkers for cancer diagnosis/prognosis (cell culture, tissue, frozen clinical biopsy samples);
2) Identification of optical redox imaging biomarkers for aging and age-associated neurodegenerative diseases (cell culture, tissue, clinical biopsy samples);
3) Imaging biomarkers for prematurity-associated lung disorders;
4) Development of optical redox imaging methods for detecting therapeutic effects (cell culture & tissue);
5) Development of label-free optical imaging methods to quantify NADH and FAD signals in formalin-fixed-paraffin-embedded tissue slides;
6) Identification of bronchopulmonary dysplasia endotypes;
Selected Publications
Xu, He N., Nioka, Shoko, Glickson, Jerry D., Chance, Britton, Li, Lin Z.: Quantitative mitochondrial redox imaging of breast cancer metastatic potential J Biomed Opt 15 (3): 036010,2010.
Xu, H. N.*, Li, L. Z.: Quantitative redox imaging biomarkers for studying tissue metabolic state and its heterogeneity J Innov Opt Health Sci 7 (2): 1430002-1-20,2014.
Xu, He N.*, Tchou, Julia., Feng, Min, Zhao, Huaqing, Li, Lin Z*.: Optical redox imaging indices discriminate human breast cancer from normal tissues J Biomed Opt 21 : 114003,2016.
He N. Xu*, Min Feng, Kavindra Nath, David Nelson, Jeff Roman, Huaqing Zhao, Zhenwu Lin, Jerry Glickson, Lin Z. Li*: Optical redox imaging of lonidamine treatment response of melanoma cells and xenografts Mol Imaging Biol 21 (3): 426-435,2019.
He N. Xu*, Huaqing Zhao, Karthikeyani Chellappa, James G. Davis, Shoko Nioka, Joseph A. Baur, Lin Z. Li*: Optical redox imaging of fixed unstained muscle slides reveals useful biological information Mol Imaging Biol 21 (3): 417-425,2019.
Allison Podsednik, Annemarie Jacob, Lin Z. Li, He N. Xu*: Relationship between optical redox status and reactive oxygen species in cancer cells React Oxyg Species 9 (26): 95-108,2020.
Xu, H. N., Lin, Z., Gandhi, C. K., Amatya, S., Wang, Y., Li, L. Z. and Floros, J.: Sex and SP-A2 dependent NAD(H) Redox Alterations in Mouse Alveolar Macrophages in Response to Ozone Exposure: Potential Implications for COVID-19 Antioxidants 9 (10): 915,2020.
Garcia-Mesa, Y., Xu, H. N., Vance, P., Gruenewald, A. L., Garza, R., Midkiff, C., Alvarez-Hernandez, X., Irwin, D. J., Gill, A. J. and Kolson, D. L.: Dimethyl fumarate, an approved multiple sclerosis treatment, reduces brain oxidative stress in SIV-infected rhesus macaques: Potential therapeutic repurposing for HIV neuroprotection Antioxidants 10 : 416,2021.
Zhigang Zhang, He N. Xu, Siyu, Li, Antonio Jr Davila, Karthikeyani Chellappa, James G., Davis, Yuxia Guan, David W. Frederick, Weiqing Chu, Huaqing Zhao, Lin Z. Li, Joseph A. Baur: Rapamycin maintains NAD+/NADH redox homeostasis in muscle cells Aging 12 : 2-15,2020.
Xu, H.N.*; Gourmaud, S.; Podsednik, A.; Li, X.; Zhao, H.; Jensen, F.E.; Talos, D.M.*; Li, L.Z.*: Optical redox imaging of ex vivo hippocampal tissue reveals age-dependent alterations in the 5xFAD mouse model of Alzheimer’s disease Metabolites 12 : 786,2022.
Academic Contact Information
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Phone: 215-746-2075