Selected Publications
Verginadis II, Velalopoulou A, Kim MM, Kim K, Paraskevaidis I, Bell B, Oliaei Motlagh SA, Karaj A, Banerjee E, Finesso G, Assenmacher CA, Radaelli E, Lu J, Lin Y, Putt ME, Diffenderfer ES, Guha C, Qin L, Metz JM, Maity A, Cengel KA, Koumenis C, Busch TM: FLASH proton reirradiation, with or without hypofractionation, reduces chronic toxicity in the normal murine intestine, skin and bone. RadioTher. Oncology : 2025.
Ni H, Reitman ZJ, Zou W, Akhtar MN, Paul R, Huang M, Zhang D, Zheng H, Zhang, R, Ma R, Ngo G, Zhang L, Diffenderfer ES, Motlagh SAO, Kim MM, Minn AJ, Dorsey JF, Foster JB, Metz J, Koumenis C, Kirsch DG, Gong Y, Fan Y.: FLASH radiation reprograms lipid metabolism and macrophage immunity and sensitizes medulloblastoma to CAR-T cell therapy.
Nat. Cancer : 2025.
Lee G, Nelson B, Koenig J, Plastaras JP, Metz JM, Yeap BY, Zhang Y, Drapek, LC, Baglini C, Ryan DP, Parikh AR, Allen JN, Clark JW, Blaszkowsky LS, Ben-Josef, E, Hong TS, Kharofa JR, Wo JY.: Long-term Outcomes of Definitive Chemoradiation
With Proton Therapy for Treatment of Carcinoma of the Anal Canal: Combined
Analysis of 2 Prospective Trials.
Int. J Radiation Oncology-Biology-Physics : 2025.
Kim K, Kim MM, Skoufos G, Diffenderfer ES, Motlagh SAO, Kokkorakis M, Koliaki, I, Morcos G, Shoniyozov K, Griffin J, Hatzigeorgiou AG, Metz JM, Lin A, Feigenberg SJ, Cengel KA, Ky B, Koumenis C, Verginadis II: FLASH Proton Radiation Therapy Mitigates Inflammatory and Fibrotic Pathways and Preserves
Cardiac Function in a Preclinical Mouse Model of Radiation-Induced Heart
Disease.
Int. J Radiation Oncology-Biology-Physics : 2024 .
Anstadt EJ, Carmona R, Berlin E, Yegya-Raman N, Venigalla S, Reddy V, Williams GR, Leibensperger MR, Wojcieszynski A, Baumann BC, Lee MK, Plastaras, JP, Furth EE, Mell LK, Metz JM, Ben-Josef E.: SMAD4 loss predicts worse overall and distant metastasis-free survival in patients with resected pancreatic adenocarcinoma.
Cancer : 2024 .
Amit U, Shagun M, Plastaras JP, Metz JM, Karasic TB, Lubas MJ, Ben-Josef E.: Clinical outcomes and risk stratification in unresectable biliary tract cancers undergoing radiation therapy.
Radiation Oncology : 2024.
erginadis II, Velalopoulou A, Kim MM, Kim K, Paraskevaidis I, Bell B, Oliaei, Motlagh SA, Karaj A, Banerjee E, Finesso G, Assenmacher CA, Radaelli E, Lu J, Lin Y, Putt ME, Diffenderfer ES, Guha C, Qin L, Metz JM, Maity A, Cengel KA, Koumenis C, Busch TM.: FLASH proton reirradiation, with or without hypofractionation, mitigates chronic toxicity in the normal murine intestine, skin, and bone.
bioRxiv [Preprint] : 2024.
Hartsell WF, Simone CB 2nd, Godes D, Maggiore J, Mehta MP, Frank SJ, Metz JM, Choi JI.: Temporal Evolution and Diagnostic Diversification of Patients Receiving
Proton Therapy in the United States: A Ten-Year Trend Analysis (2012 to 2021)
From the National Association for Proton Therapy.
Int. J Radiation Oncology-Biology-Physics : 2024.
Chowdhury P, Velalopoulou A, Verginadis II, Morcos G, Loo PE, Kim MM, Motlagh SAO, Shoniyozov K, Diffenderfer ES, Ocampo EA, Putt M, Assenmacher CA, Radaelli E, Lu J, Qin L, Liu H, Leli NM, Girdhani S, Denef N, Vander Stappen F, Cengel KA, Busch TM, Metz JM, Dong L, Lin A, Koumenis C.: Proton FLASH Radiotherapy
Ameliorates Radiation-induced Salivary Gland Dysfunction and Oral Mucositis and Increases Survival in a Mouse Model of Head and Neck Cancer. Mol Cancer Therapy. : 2024.
Bakhtiar M, Butala AA, Berlin EE, Metz JM, Bradley JD, Jones JA, Lukens JN, Paydar I, Taunk NK: Factors Associated With and Characteristics of Patients Receiving Proton Therapy at the End of Life.
International Journal Particle Therapy : 2024.
Academic Contact Information
Perelman Center for Advanced Medicine
3400 Civic Center Blvd
2 West
Philadelphia,
PA
19104
Phone: 215-349-5570
Patient appointments: 800-789-7366