Description of Research Expertise

RESEARCH INTERESTS

Control and function of human embryonic globin genes.

Key words: Globin, embryonic, sickle cell anemia, thalassemia, mRNA, prothrombin.

Selected Publications

Jiang, Y., Xu, X.-S., and Russell, J.E.: The high stability of [beta]-globin mRNA requires site-specific binding of factors that remodel the structure of its 3'UTR. The 8th Cooley's Anemia Symposium, New York Academy of Sciences, March 17-19 : 2005.

Jiang, Y., Xu, X.-S., and Russell, J.E.: The high stability of human [beta]-globin mRNA is determined by a specific cis-element within its 3'UTR. 28th Annual Meeting of the National Sickle Cell Disease Program, Cincinnati, April 9-13 : 2005.

He, Z., and Russell, J.E.: Evidence that differential stabilization of [beta]-like globin mRNAs is mediated by specific determinants in their 3'UTRs. 28th Annual Meeting of the National Sickle Cell Disease Program, Cincinnati, April 9-13 : 2005.

Russell, J.E.: Adaptive post-transcriptional processes mitigate globin chain imbalance in [beta]-thalassemic erythrocytes 27th Annual Meeting of the National Sickle Cell Disease Program, Los Angeles, April 18-21 : 2004.

He, Z., and Russell, J.E.: Co-expression of human [zeta] globin corrects the sickle phenotype in mouse models of sickle cell disease 27th Annual Meeting of the National Sickle Cell Disease Program, Los Angeles, April 18-21 : 2004.

Frehm, E.J., Russell, J.E., and Gow, A.J.: Genetic and pharmacologic modulation of nitric oxide-hemoglobin reactivity Eastern Society for Pediatric Research, Old Greenwich CT, March 26-28 : 2004.

Russell, J.E.: Hemoglobinopathies and thalassemias. Medical Knowledge Self-Assessment Program 13 : 30-32,2003.

View all publications

Academic Contact Information

Biomedical Research Building, Room 713
421 Curie Boulevard
Philadelphia, PA 19104
Phone: 215-898-4406
Patient appointments: 800-789-7366