Description of Research Expertise
Dr. Christie's career is focused on translational research studies of the risks, pathogenesis, treatment, and outcomes of acute lung injury in the transplant and non-transplant human populations. His research integrates new knowledge generated from bench studies with epidemiology approaches in well-phenotyped, large human populations to generate new definitions of human syndromes, improved diagnostics and prognostics, and targeted therapy approaches in advanced lung diseases and critical illness.
Dr. Christie is the founder of the lung transplant outcomes group (LTOG), which is a multicentered cohort study the etiology and pathogenesis of acute lung injury following lung transplantation (termed primary graft dysfunction). Active LTOG research themes focus on the mechanisms of clinical factors that elevate PGD risk, including donor smoke exposure, recipient obesity and body composition, pulmonary hypertension, alterations in lung microbiome, and autoimmunity to lung collagens. His multidisciplinary lung transplant research focuses on genetics, innate immunity, regulatory T-cells, innate lymphoid cell (ILC) populations in the lung, ischemia reperfusion injury, inflammation, and autoimmunity.
Selected Publications
Tatsuki Koyama, Zhiguo Zhao, John R Balmes, Carolyn S Calfee, Michael A Matthay, John P Reilly, Mary K Porteous, Joshua M Diamond, Jason D Christie, Edward Cantu, Lorraine B Ware; Lung Transplant Outcomes Group: Long-term air pollution exposure and the risk of primary graft dysfunction after lung transplantation J Heart Lung Transplant 24 : 1053-2498,2024.
Emily A Vail, Vicky W Tam, Elizabeth M Sonnenberg, Nikhil R Lavu, Peter P Reese, Peter L Abt, Niels D Martin, Richard D Hasz, Kim M Olthoff, Meeta P Kerlin, Jason D Christie, Mark D Neuman, Vishnu S Potluri: Characterizing proximity and transfers of deceased organ donors to donor care units in the United States Am J Transplant
6 : 983-992,2024.
Emily A Vail, Xingmei Wang, Douglas E Schaubel, Peter P Reese, Edward Cantu, Niels D Martin, Peter L Abt, Kim M Olthoff, Meeta P Kerlin, Jason D Christie, Mark D Neuman: Lung Donation and Transplant Recipient Outcomes at Independent vs Hospital-Based Donor Care Units JAMA Netw Open : 2024.
Edward Cantu, Joshua Diamond, Nikhil Ganjoo, Ana Nottigham, Christian Vivar Ramon, Madeline McCurry, Jacqueline Friskey, Dun Jin, Michaela R Anderson, Jessica Lisowski, Audrey Le Mahajan, A Russell Localio, Robert Gallop, Jesse Hsu, Jason Christie, Douglas E Schaubel: Scoring donor lungs for graft failure risk: The Lung Donor Risk Index (LDRI) Am J Transplant 5 : 839-849,2024.
Zhao G, Gentile ME, Xue L, Cosgriff CV, Weiner AI, Adams-Tzivelekidis S, Wong J, Li X, Kass-Gergi S, Holcomb NP, Basal MC, Stewart KM, Planer JD, Cantu E, Christie JD, Crespo MM, Mitchell MJ, Meyer NJ, Vaughan AE.: Vascular Endothelial-derived SPARCL1 Exacerbates Viral Pneumonia Through Pro-Inflammatory Macrophage Activation bioRxiv : 2024.
Nadir Yehya, Thomas J Booth, Gnana D Ardhanari, Jill M Thompson, L K Metthew Lam, Jacob E Till, Mark V Mai, Garrett Keim, Daniel J McKeone, E Scott Halstead, Patrick Lahni, Brian M Varisco, Wanding Zhou, Erica L Carpenter, Jason D Christie, Nilam S Mangalmurti: Inflammatory and tissue injury marker dynamics in pediatric acute respiratory distress syndrome The Journal of Clinical Investigation 10 : 2024.
Joshua M Diamond, Michaela R Anderson, Edward Cantu, Emily S Clausen, Michael G S Shashaty, Laurel Kalman, Michelle Oyster, Maria M Crespo, Christian A Bermudez, Luke Benvenuto, Scott M Palmer, Laurie D Snyder, Matthew G Hartwig, Keith Wille, Chadi Hage, John F McDyer, Christian A Merlo, Pali D Shah, Jonathan B Orens, Ghundeep S Dhillon, Vibha N Lama, Mrunal G Patel, Jonathan P Singer, Ramsey R Hachem, Andrew P Michelson, Jesse Hsu, A Russell Localio, Jason D Christie: Development and validation of primary graft dysfunction predictive algorithm for lung transplant candidates J Heart Lung Transplant
4 : 633-641,2024.
Diamond JM, Benvenuto L, Claridge T, Witek S, Christie JD, Singer JP, Anderson MR.: Provider beliefs and practices regarding the management of obesity in lung transplant recipients JHLT Open : 2024.
Diamond JM, Cantu E, Calfee CS, Anderson MR, Clausen ES, Shashaty MGS, Courtwright AM, Kalman L, Oyster M, Crespo MM, Bermudez CA, Benvenuto L, Palmer SM, Snyder LD, Hartwig MG, Todd JL, Wille K, Hage C, McDyer JF, Merlo CA, Shah PD, Orens JB, Dhillon GS, Weinacker AB, Lama VN, Patel MG, Singer JP, Hsu J, Localio AR, Christie JD.: The Impact of Donor Smoking on Primary Graft Dysfunction and Mortality after Lung Transplantation Am J Respir Crit Care Med 209 : 91-100,2024.
Christian Bermudez, Francisca Bermudez, Andrew Courtwright, Thomas Richards, Joshua Diamond, Marisa Cevasco, Emily Blumberg, Jason Christie, Asad Usman, Maria M Crespo: Lung transplantation for COVID-2019 respiratory failure in the United States: Outcomes 1-year posttransplant and the impact of preoperative extracorporeal membrane oxygenation support J Thorac Cardiovasc Surg
1 : 384-395,2024.
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Academic Contact Information
Division of Pulmonary and Critical Care Medicine
Hospital of the University of Pennsylvania
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania School of Medicine
423 Guardian Drive
221 Blockley Hall
Philadelphia,
PA
19104
Phone: 215-573-3209
Patient appointments: 800-789-7366