Description of Research Expertise
Jay Dorsey, MD, PhD has been continuously funded by the NIH for the past decade. He has expertise in genomics, precision medicine, circulating tumor material/liquid biopsy, molecular diagnostics, cancer biomarkers, nanoparticle therapeutics, preclinical tumor models, and clinical trials. His lab focuses on translational-facing research that explores areas of brain tumor biology, biomarkers of resistance/sensitivity to radiation and chemotherapies and identification of predictive/prognostic single-cell biomarkers of solid tumors, including GBM, lung and melanoma. He is Co-Leader of the Abramson Cancer Center's RadOnc Translational Center of Excellence.
Dr. Dorsey also serves as a standing member of the K99/R00 transition to independence NIH study section and is the PI and Director of the DEI-focused (NIH R25-funded undergraduate research pipeline program) SUPERS@PENN program which seeks to introduce the next generation of biomedical scientists to undergraduate research in oncology/medical physics/bioengineering/radiology/radiation biology.
He has published in journals such as Cancer Research, Cell, Nature Communications, Nature Cancer, ACS Nano, Int J Radiat Oncol Biol Phys., and Molecular Cancer Research.
His work has been funded by ASCO, RSNA, Burroughs Wellcome Fund, and the National Institutes of Health.
Selected Publications
Dastgheyb SS, Dreyfuss AD, LaRiviere MJ, Mohiuddin JJ, Baumann BC, Shabason J, Lustig RA, Dorsey JF, Lin A, Grady SM, O'Malley BW, Lee JYK, Newman JG, Schuster JM, Alonso-Basanta M.: A Prospective Phase I/II Clinical Trial of High-Dose Proton Therapy for Chordomas and Chondrosarcomas Adv Radiat Oncol 9 : 101456,2024.
Zhang D, Cleveland AH, Krimitza E, Han K, Yi C, Stout AL, Zou W, Dorsey JF, Gong Y, Fan Y.: Spatial analysis of tissue immunity and vascularity by light sheet fluorescence microscopy Nat Protoc : 2024.
Yang F, Akhtar MN, Zhang D, El-Mayta R, Shin J, Dorsey JF, Zhang L, Xu X, Guo W, Bagley SJ, Fuchs SY, Koumenis C, Lathia JD, Mitchell MJ, Gong Y, Fan Y.: An immunosuppressive vascular niche drives macrophage polarization and immunotherapy resistance in glioblastoma Sci Adv : 2024.
Paul R, Dorsey JF, Fan Y: Cell plasticity, senescence, and quiescence in
cancer stem cells: Biological and therapeutic implications Pharmacol Ther. : 2022.
Paul R, Dorsey JF, Fan Y.: Cell plasticity, senescence, and quiescence in cancer stem cells: Biological and therapeutic implications Pharmacol Ther : 2022.
Yang AI, Mensah-Brown KG, Shekhtman EF, Kvint S, Wathen CA, Hitti FL, Alonso-Basanta M, Avery SM, Dorsey JF, Y K Lee J.: Gamma Knife radiosurgery for trigeminal neuralgia provides greater pain relief at higher dose rates J Radiosurg SBRT : 2022.
Lee SH, Kao GD, Feigenberg SJ, Dorsey JF, Frick MA, Jean-Baptiste S, Uche CZ, Cengel KA, Levin WP, Berman AT, Aggarwal C, Fan Y, Xiao Y: Multiblock Discriminant Analysis of Integrative 18F-FDG-PET/CT Radiomics for Predicting Circulating Tumor Cells in Early-Stage Non-small Cell Lung Cancer Treated With Stereotactic Body Radiation Therapy Int J Radiat Oncol Biol Phys. 110 (5): 1451-1465,2021.
Lee SH, Kao GD, Feigenberg SJ, Dorsey JF, Frick MA, Jean-Baptiste S, Uche CZ, Cengel KA, Levin WP, Berman AT, Aggarwal C, Fan Y, Xiao Y.: Multiblock Discriminant Analysis of Integrative (18)F-FDG-PET/CT Radiomics for Predicting Circulating Tumor Cells in Early-Stage Non-small Cell Lung Cancer Treated With Stereotactic Body Radiation Therapy Int J Radiat Oncol Biol Phys 110 : 1451-1465,2021.
Mathilde Bouché, Yuxi C Dong, Saad Sheikh, Kimberly Taing, Deeksha Saxena, Jessica C Hsu, Minna H Chen, Ryan D Salinas, Hongjun Song, Jason A Burdick, Jay Dorsey, David P Cormode: Novel Treatment for Glioblastoma Delivered by a Radiation Responsive and Radiopaque Hydrogel ACS Biomater Sci Eng. : 2021.
Yang F, He Z, Duan H, Zhang D, Li J, Yang H, Dorsey JF, Zou W, Nabavizadeh, SA, Bagley SJ, Abdullah K, Brem S, Zhang L, Xu X, Byrne KT, Vonderheide RH, Gong Y, Fan Y.: Synergistic immunotherapy of glioblastoma by dual targeting of IL-6
and CD40 Nat Commun. 12 (1): 2021.
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Academic Contact Information
Department of Radiation Oncology
Perelman Center for Advanced Medicine
Bldg 421 SCTR 8-135
3400 Civic Center Blvd
Philadelphia,
PA
19104
Phone: 215-662-2428
Patient appointments: 800-789-7366