Description of Research Expertise

Research Interests: The Orthmann-Murphy laboratory studies the dynamic role of glial cells in acquired and inherited demyelinating disease.

Key Words: glia, myelin, multiple sclerosis, demyelination, remyelination

Techniques: multiphoton imaging

Selected Publications

Laura A Adang, Joshua L Bonkowsky, Jaap Jan Boelens, Eric Mallack, Rebecca Ahrens-Nicklas, John A Bernat, Annette Bley, Barbara Burton, Alejandra Darling, Florian Eichler, Erik Eklund, Lisa Emrick, Maria Escolar, Ali Fatemi, Jamie L Fraser, Amy Gaviglio, Stephanie Keller, Marc C Patterson, Paul Orchard, Jennifer Orthmann-Murphy, Jonathan D Santoro, Ludger Schöls, Caroline Sevin, Isha N Srivastava, Deepa Rajan, Jennifer P Rubin, Keith Van Haren, Melissa Wasserstein, Ayelet Zerem, Francesca Fumagalli, Lucia Laugwitz, Adeline Vanderver: Consensus guidelines for the monitoring and management of metachromatic leukodystrophy in the United States Cytotherapy 26 (7) : 739-748,2024.

Aaron Baldwin, Juliette Copeland, Meron Azage, Laynie Dratch, Kelsey Johnson, Rachel A Paul, Defne A Amado, Michael Baer, Andres Deik, Lauren B Elman, Michael Guo, Ali G Hamedani, David J Irwin, Aaron Lasker, Jennifer Orthmann-Murphy, Colin C Quinn, Thomas F Tropea, Steven S Scherer, Russell T Shinohara, Roy H Hamilton, Colin A Ellis: Disparities in genetic testing for neurologic disorders Neurology 102 (6) : https://doi.org/10.1212/WNL.000000000020916,2024.

Dratch L, Azage M, Baldwin A, Johnson K, Paul RA, Bardakjian TM, Michon SC, Amado DA, Baer M, Deik AF, Elman LB, Gonzalez-Alegre P, Guo MH, Hamedani AG, Irwin DJ, Lasker A, Orthmann-Murphy J, Quinn C, Tropea TF, Scherer SS, Ellis CA.: Genetic testing in adults with neurologic disorders: indications, approach, and clinical impacts. J Neurology 271 (2) : 733-747,2024.

Felipe J.S. Jones and Jennifer Orthmann-Murphy: Clinical Reasoning: A 26-year-old woman with chronic progressive gait dysfunction Neurology : 2024.

Anjana Sevagamoorthy, Adeline Vanderver, Jamie L. Fraser, and Jennifer Orthmann-Murphy: Glial Origins of Inherited White Matter Disorders Additional Perspectives on Glia in Cold Spring Harb Perspect Biol : 2024.

Rebecca L. Koch, Claudia Soler-Alfonso, Bridget T. Kiely, Akihiro Asai, Ariana L. Smith, Deeksha S. Bali, Peter B. Kang, Andrew P. Landstrom, H. Orhan Akman, T. Andrew Burrow, Jennifer L. Orthmann-Murphy, Deberah S. Goldman, Surekha Pendyal, Areeg H. El-Gharbawy, Stephanie L. Austin, Laura E. Case, Raphael Schiffmann, Michio Hirano, and Priya S. Kishnani: Diagnosis and management of glycogen storage disease type IV, including adult polyglucosan body disease: A clinical practice resource Molecular Genetics and Metabolism : 2023.

Hannah Loo and Jennifer L Orthmann-Murphy: How do deep cortical microglia impair remyelination? Gordon Research Conference Poster - Glial Biology : 2023.

Joseph Gallegos, Hannah Loo, Thomas Malloy, Jennifer L Orthmann-Murphy: Does a toxic reactive astrocyte subtype influence oligodendrocyte recovery in the cortex? ACTRIMS Annual Meeting Poster 434 : 2023.

Al-alya Alsabah, Zehra Isik Hasiloglu, Rami Massie, Bernard Brais, *Jennifer Orthmann Murphy, *Roberta La Piana: Prevalence of Peripheral Nervous System Involvement in Adult Leukodystrophies AAN annual meeting : 2023.

Alexandra Kornbluh and Jennifer L Orthmann-Murphy: A Practical Approach to Longitudinal Neurological Care of Adults With X-linked Adrenoleukodystrophy and Adrenomyeloneuropathy (X-ALD/AMN) American Academy of Neurology Annual Meeting Poster P17-4.009 : 2022.

Academic Contact Information

Department of Neurology
Hospital of the University of Pennsylvania
3 Gates
3400 Spruce Street
Philadelphia, PA 19104
Phone: 215-662-3606
Patient appointments: 800-789-7366