Description of Research Expertise

Dr. Reilly conducts translational patient-oriented research in critical care medicine aimed at understanding clinical and molecular risk factors for sepsis and the acute respiratory distress syndrome (ARDS). He collaborates with other members of the faculty to conduct prospective cohort studies of critically ill patients with severe sepsis and acute trauma. Currently, his research focuses on understanding a novel risk factors for ARDS in the setting of trauma and severe sepsis, including ABO blood type A and chronic exposure to ambient air pollutants. His ultimate goal is to provide mechanistic insights into critical illness that can be translated to improved care for patients suffering from sepsis and ARDS.

Selected Publications

Reilly JP, Zhao Z, Shashaty MGS, Koyama T, Christie JD, Lanken PN, Wang C, Balmes JR, Matthay MA, Calfee CS, Ware LB.: Low to moderate air pollutant exposure and acute respiratory distress syndrome after severe trauma. American Journal of Respiratory and Critical Care Medicine. 199 (1): 62-70,2019.

Reilly JP, Wang F, Jones TK, Palakshappa JA, Anderson BJ, Shashaty MGS, Dunn TG, Johannson ED, Riley TR, Lim B, Abbott JA, Ittner CAG, Cantu E, Lin X, Mikacenic C, Wurfel MM, Christiani DC, Calfee CS, Matthay MA, Christie JD, Feng R, Meyer NJ.: Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: Evidence from mendelian randomization and mediation analysis. Intensive Care Medicine. 44 (11): 1849-1858,2018.

Meyer NJ, Reilly JP, Anderson BJ, Palakshappa JA, Dunn T, Shashaty MGS, Feng R, Christie JD, Palardy JE, Opal SM.: Mortality benefit of recombinant human interleukin-1 receptor antagonist (rhIL1RA) for sepsis varies by initial IL1RA plasma concentration. Critical Care Medicine. 46 (1): 21-28,2018.

Meyer NJ, Reilly JP, Feng R, Christie JD, Hazen SL, Albert CJ, Hartman CL, Franke JD, McHowat J, Ford DA.: Myeloperoxidase-derived 2-chlorofatty acids contribute to human sepsis mortality via acute respiratory distress syndrome. JCI Insight. 2 (23): e96432,2017.

Reilly JP, Christie JD: Is it possible to prevent ARDS? Journal of the American Medical Association (JAMA). 315 (22): 2403-2405,2016.

Reilly JP, Anderson BJ, Mangalmurti NS, Nguyen TD, Holena DN, Wu Q, Nguyen ET, Reilly MP, Lanken PN, Christie JD, Meyer NJ, Shashaty MGS: The ABO histo-blood group and acute kidney injury in critically ill trauma and sepsis patients. Clinical Journal of the American Society of Nephrology. 10 (11): 1911-1920,2015.

Zhong M, Zhang H, Reilly JP, Christie JD, Ishihara M, Kumagai T, Azadi P, Reilly MP: ABO blood group as a model for platelet glycan modification in arterial thrombosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 35 (7): 1570-1578,2015.

Reilly JP, Bellamy S, Shashaty MGS, Gallop R, Meyer NJ, Lanken PN, Kaplan S, Holena DN, May AK, Ware LB, Christie JD: Heterogeneous phenotypes of the acute respiratory distress syndrome after major trauma. Annals of the American Thoracic Society. 11 (5): 728-736,2014.

Reilly JP, Meyer NJ, Shashaty MGS, Feng R, Lanken PN, Gallop R, Kaplan S, Herlim M, Oz NL, Hiciano I, Campbell A, Holena D, Reilly MP, Christie JD: ABO blood type A is associated with increased risk of acute respiratory distress syndrome in whites following both major trauma and severe sepsis. Chest. 145 (4): 753-761,2014.

Qing DY, Conegliano D, Shashaty MG, Seo J, Reilly JP, Worthen GS, Huh D, Meyer NJ, Mangalmurti NS: RBCs induce necroptosis of lung endothelial cells and increase susceptibility to lung inflammation. American Journal of Respiratory and Critical Care Medicine. 190 (11): 1243-1254,2014.

Academic Contact Information

Hospital of the University of Pennsylvania
5042 Gibson Building
3400 Spruce Street
Philadelphia, PA 19104
Patient appointments: 800-789-7366