Description of Research Expertise
1. Keratinocyte growth and differentiation-mechanisms of growth control
2. Skin cancer-squamous cell carcinoma, SCCIS, Actinic keratoses
3. Signal transduction-tyrosine kinases and adaptor molecules
4. Murine models of human diseases.
5. Use of organotypic cultures to model disease.
6. Effects of UVB on keratinocytes
7. Psoriasis
8. Dermatopathology-alopecia, appendageal tumors, cancer.
Selected Publications
Maeno H, Suzuki-Horiuchi Y, Funakoshi A, Chumsakul O, Sato Y, Ishii T, Seykora JT: miR-4521-A novel biomarker for human lentigos Exp Dermatol. 2024 33 (6): 2024.
Harris JC, Prouty SM, Nelson MA, Sung DC, Nelson AM, Seykora JT, Kambayashi T, Grice EA.: Laser Capture Microdissection-based RNAseq for Profiling Mouse and Human Sebaceous Gland Transcriptomes. J Invest Dermatol 144 : 2024.
Yang B, Alimperti S, Gonzalez MV, Dentchev T, Kim M, Suh J, Titchenell PM, Ko KI, Seykora J, Benakanakere M, Graves DT: Reepithelialization of Diabetic Skin and Mucosal Wounds Is Rescued by Treatment With Epigenetic Inhibitors. Diabetes. 73 : 120-134,2024.
Ko EK, Anderson A, D'souza C, Zou J, Huang S, Cho S, Alawi F, Prouty S, Lee V, Yoon S, Krick K, Horiuchi Y, Ge K, Seykora JT, Capell BC.: Disruption of H3K36 methylation provokes cellular plasticity to drive aberrant glandular formation and squamous carcinogenesis. Dev Cell. 59 (2): 2024.
Burks HE, Pokorny JL, Koetsier JL, Roth-Carter QR, Arnette CR, Gerami P, Seykora JT, Johnson JL, Ren Z, Green KJ.: Melanoma cells repress Desmoglein 1 in keratinocytes to promote tumor cell migration. J Cell Biol. J Cell Biol. Nov 6;222(11) : 2023.
Maldonado López AM, Ko EK, Huang S, Pacella G, Kuprasertkul N, D'souza CA, Reyes Hueros RA, Shen H, Stoute J, Elashal H, Sinkfield M, Anderson A, Prouty S, Li HB, Seykora JT, Liu KF, Capell BC.: Mettl3-catalyzed m6A regulates histone modifier and modification expression in self-renewing somatic tissue. Sci Adv. 2023 Sep;9(35) : 2023.
Jackson TK, Sow Y, Ayoade KO, Seykora JT, Taylor SC, Ogunleye T.: Central centrifugal cicatricial alopecia in males. J Am Acad Dermatol. 2023 24 : 2023.
Roche FC, Hedberg ML, Fischer AS, Ray A, Dentchev T, Rice X, Taylor SC, Seykora JT.: Activation of STAT3 in lymphocytes associated with central centrifugal cicatricial alopecia. J Am Acad Dermatol. 21:S0190-9622(23)00202-5. : 2023.
"Bhattacharya S, Basu S, Sheng E, Murphy C, Wei J, Kersh AE, Nelson CA, Bryer JS, Ashchyan HA, Steele K, Forrestel A, Seykora JT, Micheletti RG, James WD, Rosenbach M, Leung TH: Identification of a neutrophil-specific PIK3R1 mutation facilitates targeted treatment in a patient with Sweet syndrome" J Clin Invest 133 (1): 2023.
Zuraski CR, Wales C, Nguyen CV, Chan EF, Kovarik C, Seykora JT, Elenitsas R, Moshiri AS.: Cutaneous Ganglioneuromas With Overlying Epidermal Hyperplasia: A Case Series Presentation and Proposal of Potential Etiopathogenesis. Am J Dermatopathol. 2022 Nov 1;44(11):812-816. doi: 10.1097/DAD.0000000000002249. Epub 2022 Jul 19. PMID: 35925148. Nov 1;44(11):812-816 : 2022.
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Academic Contact Information
Department of Dermatology
Room 1011, Biomedical Research Building
421 Curie Blvd
Philadelphia,
PA
19104-6142
Phone: 215-898-0170
Patient appointments: 800-789-7366