Description of Research Expertise

My laboratory focuses on the effects of traumatic brain injury on the limbic system, including the hippocampus, PFC, and amygdala. We are particularly interested in the changes in coding in these structures, as well as the interactions between them, in both cognition and emotional processing. We are developing new targets of neuromodulation for these regions and their connections as well.

Selected Publications

Adam, Christopher D., Mirzakhalili, Ehsan, Gagnon, Kimberly G., Cottone, Carlo, Arena, John D., Ulyanova, Alexandra V., Johnson, Victoria E., Wolf, John A.: Disrupted Hippocampal Theta-Gamma Coupling and Spike-field Coherence Following Experimental Traumatic Brain Injury eLife : 2024.

Harary PM, Jgamadze D, Kim J, Wolf JA, Song H, Ming GL, Cullen DK, Chen HI.: Cell Replacement Therapy for Brain Repair: Recent Progress and Remaining Challenges for Treating Parkinson's Disease and Cortical Injury Brain Sci 13 : 1654,2023.

Lu Y, Lee J, Li J, Allu SR, Wang J, Kim H, Bullaughey KL, Fisher SA, Nordgren CE, Rosario JG, Anderson SA, Ulyanova AV, Brem S, Chen HI, Wolf JA, Grady MS, Vinogradov SA, Kim J, Eberwine J.: CHEX-seq detects single-cell genomic single-stranded DNA with catalytical potential Nat Commun 14 : 7346,2023.

Alexandra V. Ulyanova, Carlo Cottone, Christopher D. Adam, Nikhil Maheshwari, Michael R. Grovola, Oceane E. Fruchet, Jami Alamar, Paul F. Koch, Victoria E. Johnson, D. Kacy Cullen, John A. Wolf: Hippocampal Interneuronal Dysfunction and Hyperexcitability in a Porcine Model of Concussion Communications Biology : 2023.

James P. Harris, Constance J. Mietus, Kevin D. Browne, Kathryn L. Wofford, Carolyn E. Keating, Daniel P. Brown, Brian N. Johnson, John A. Wolf, Douglas H. Smith, Akiva S. Cohen, John E. Duda, D. Kacy Cullen: Neuronal somatic plasmalemmal permeability and dendritic beading caused by head rotational traumatic brain injury in pigs–An exploratory study Frontiers Cellular Neuroscience 17 : 2023.

Harris JP, Mietus CJ, Browne KD, Wofford KL, Keating CE, Brown DP, Johnson BN, Wolf JA, Smith DH, Cohen AS, Duda JE, Cullen DK.: Neuronal somatic plasmalemmal permeability and dendritic beading caused by head rotational traumatic brain injury in pigs-An exploratory study Front Cell Neurosci 17 : 1055455,2023.

Eberwine J, Kim J, Anafi RC, Brem S, Bucan M, Fisher SA, Grady MS, Herr AE, Issadore D, Jeong H, Kim H, Lee D, Rubakhin S, Sul JY, Sweedler JV, Wolf JA, Zaret KS, Zou J.: Subcellular omics: a new frontier pushing the limits of resolution, complexity and throughput Nat Methods : 2023.

Jgamadze D, Lim JT, Zhang Z, Harary PM, Germi J, Mensah-Brown K, Adam CD, Mirzakhalili E, Singh S, Gu JB, Blue R, Dedhia M, Fu M, Jacob F, Qian X, Gagnon K, Sergison M, Fruchet O, Rahaman I, Wang H, Xu F, Xiao R, Contreras D, Wolf JA, Song H, Ming GL, Chen HI.: Structural and functional integration of human forebrain organoids with the injured adult rat visual system Cell Stem Cell 30 : 137-152,2023.

Smith DH, Burrell JC, Browne KD, Katiyar KS, Ezra MI, Dutton JL, Morand JP, Struzyna LA, Laimo FA, Chen HI, Wolf JA, Kaplan HM, Rosen JM, Ledebur HC, Zager EL, Ali ZS, Cullen DK.: Tissue-engineered grafts exploit axon-facilitated axon regeneration and pathway protection to enable recovery after 5-cm nerve defects in pigs Sci Adv 8 : eabm3291,2022.

Galanopoulou, Aristea S., Löscher, Wolfgang, Lubbers, Laura, O’Brien, Terence J., Staley, Kevin, Vezzani, Annamaria, D’Ambrosio, Raimondo, White, H. Steve, Sontheimer, Harald, Wolf, John A., Twyman, Roy, Whittemore, Vicky, Wilcox, Karen S., Klein, Brian: Antiepileptogenesis and disease modification: Progress, challenges, and the path forward—Report of the Preclinical Working Group of the 2018 NINDS-sponsored antiepileptogenesis and disease modification workshop Epilepsia Open 6 (2): 276-296,2021.

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Academic Contact Information

Rm.172A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104
Phone: 215-746-4680