Karen Marie Puopolo, MD, PhD (she/her/hers)

Neonatology and Newborn Services

Sees newborns through age 1 month

Chief, Section on Newborn Medicine, Pennsylvania Hospital
Professor of Pediatrics (Neonatology & Newborn Services) at the Children's Hospital of Philadelphia
Dr. Puopolo is an independent physician who is not employed by Penn Medicine.

Call 800-789-7366 Request Appointment

Programs and Centers

Penn Medicine's programs and centers combine doctors from many disciplines to coordinate care from start to finish. Dr. Puopolo is part of these programs:

Penn Neonatology Program (Intensive Care Nursery)

Board Certification

Neonatal-Perinatal Medicine, 2003

Education and Training

Medical School: Tufts University School of Medicine
Residency: Children's Hospital of Boston
Fellowship: Children's Hospital of Boston

Primary Location

Neonatology and Newborn Services Pennsylvania Hospital

Pennsylvania Hospital
2nd Floor
800 Spruce Street
Philadelphia, PA 19107

Map Call 800-789-7366

View details

Penn Medicine Hospital Privileges

Pennsylvania Hospital: Has privileges to treat patients in the hospital.

Selected Publications

Medoro AK, Puopolo KM: Transplacental Antibodies: Role of Maternal Vaccines and Immunity Clin Perinatol 52 (1): 101-113,2025.

Mukhopadhyay S, Puopolo KM: Perinatal and Neonatal Infections: Core Concepts, Emerging Issues, and Future Perspectives Clin Perinatol 52 (1): xix-xxii,2025.

Coggins SA, Wade KC, Watt KM, Downes KJ, Puopolo KM.: Vancomycin Concentrations in Umbilical Cord Blood After Intrapartum Exposure Obstet Gynecol : 2025.

Mukhopadhyay S, Kaufman DA, Saha S, Puopolo KM, Flannery DD, Weimer KED, Greenberg RG, Sanchez PJ, Eichenwald EC, Cotten CM, Stoll BJ, Laptook A.: Late-Onset Sepsis Among Extremely Preterm Infants During the COVID-19 Pandemic Pediatrics 155 (2): e2024067675,2025.

Ratner AJ, Nizet V, Puopolo KM: Group B Streptococcal Infections Remington and Klein's Infectious Diseases of the Fetus and Newborn Infant : 2025.

Coggins SA, Puopolo KM.: Intrapartum antibiotic prophylaxis for group B Streptococcus: what exactly is adequate? Arch Dis Child Fetal Neonatal Ed : 2024.

Coggins SA, Wade KC, Watt KM, Downes KJ, Puopolo KM.: Umbilical cord blood gentamicin concentrations following maternally-administered intrapartum exposures Pediatr Res : 2024.

Puopolo KM: Postnatally acquired cytomegalovirus infection among preterm infants Curr Opin Infect Dis 37 (5): 425-430,2024.

Kuzniewicz MW, Escobar GJ, Forquer H, Li S, Shu D, Kipnis P, Fischer A, Puopolo KM.: Update to the Neonatal Early-Onset Sepsis Calculator Utilizing a Contemporary Cohort Pediatrics 154 (4): e2023065267,2024.

Green MB, Zevallos Barboza A, Mukhopadhyay S, Gerber JS, Morowitz MJ, Puopolo KM, Flannery DD.: Anaerobe-targeted antibiotic therapy in the neonatal intensive care unit J Pediatric Infect Dis Soc : 2024.

View all publications

Academic Contact Information

Children's Hospital of Philadelphia
Newborn Care at Pennsylvania Hospital
800 Spruce Street - 2nd Floor
Philadelphia, PA 19107
Phone: 215-829-3301
Patient appointments: 800-789-7366

American Academy of Pediatrics Section on Neonatal-Perinatal Medicine, National
American Academy of Pediatrics, National
American Academy of Pediatrics, National
American Pediatric Society, National
Center for Pediatric Clinical Excellence (now Clinical Futures), Local
Centers for Disease Control and Prevention and Vermont-Oxford Network, National
Centers for Disease Control and Prevention, National
iNICQ: Choosing Antibiotics Wisely, Vermont-Oxford Network, National
Massachusetts Medical Society, Local
Pediatric Academic Society Annual Meeting Scientific Abstract Reviewer, National
Pediatric Infectious Disease Society, National
Pennsylvania Perinatal Quality Collaborativre, Local
Philadelphia Department of Public Health, Local
Philadelphia Department of Public Health, Local
Society for Pediatric Research, National