Description of Research Expertise
Dr. Roshkovan completed a Thoracic Radiology fellowship and Abdominal Imaging fellowship at the University of Pennsylvania Perelman School of Medicine. His primary research focus in developing improved measures of cancer detection and therapy response assessment in thoracic oncology. His work centers on functioning as an active member of an interdisciplinary research team dedicated to advances in thoracic oncology including therapeutic clinical trials and development of novel radiomic signatures for non-small cell therapy response prediction and improving therapy response assessment in NSCLC and mesothelioma.
In addition, Dr. Roshkovan is actively engaged in research efforts at the institutional level at Penn as well as the national level where he is an integral part of teams tasked to procure and curate COVID-19 imaging and clinical data so as to accelerate innovation and discovery in improved ways of detecting and characterizing COVID-19 pneumonia. He is also lead in a research project at Penn evaluating utilization of computed tomography (CT) in patients suspected of COVID-19 pneumonia.
He is a member of the Penn Thoracic Oncology Radiomics Working Group, the iMig Pleural Expert Panel and the ACR COVID-19 Registry Steering Committee
Selected Publications
Singh A, Roshkovan L, Horng H, Chen A, Katz SI, Thompson JC, Kontos D.: Radiomics Analysis for the Identification of Invasive Pulmonary Subsolid Nodules From Longitudinal Presurgical CT Scans J Thorac Imaging : 2024.
Margaret Stalker, Suzanne Walker, Emily S. Lebow, Evan P. Anderson, Leonid Roshkovan, Sharyn I. Katz, Leslie Litzky, Andrew R. Haas, Sunil Singhal, Corey J. Langer, Keith A. Cengel, and Melina Elpi Marmarelis: Brain metastases in patients with pleural mesothelioma receiving dual checkpoint blockade compared to single-agent checkpoint blockade or chemotherapy. Journal of Clinical Oncology 42 (16): 2024.
Im JY, Halliburton SS, Mei K, Perkins AE, Wong E, Roshkovan L, Sandvold OF, Liu LP, Gang GJ, Noël PB.: Patient-derived PixelPrint phantoms for evaluating clinical imaging performance of a deep learning CT reconstruction algorithm Phys Med Biol 69 : 115009,2024.
W. Chen, Lauren K. Brady, Eric A. Cohen, Walter C. Mankowski, Leonid Roshkovan, Mohammed Qutaish, Sharyn Katz, Patricia G.Castro, Nora Pencheva, Maria Jure-Kunkel, Brandon W. Higgs, Despina Kontos.: Evaluating the potential of radiomics features to predict
outcome to an anti body-drug conjugate therapy in non-small cell lung cancer patients.
AACR 2024, San Diego. : 2024.
Apurva Singh, Hannah Horng, Leonid Roshkovan, Charu Aggarwal, Erica L. Carpenter, Sharyn I. Katz, Despina Kontos.: Exploring the prognostic power and biological significance of a
robust radiomic biomarker of overall survival in advanced non-small cell lung cancer patients
treated with first-line immunotherapy. SPIE Medical Imaging Symposium 2024, San Diego. : 2024.
Andrew William Chen, Ohm Patel, Eric A. Cohen, Leonid Roshkovan, Despina Kontos.: Radiomic phenotypes of the background lung parenchyma from [18]F-FDG PET/CT images can augment tumor radiomics and clinical factors in predicting response after surgical resection of tumors in patients with non-small cell lung cancer. SPIE Medical Imaging Symposium 2024, San Diego : 2024.
K. Mei, L. Roshkovan, S. Sharma, S. Ross, S. Wu, Z. Yu, R. Thompson, P. Noël.: Ultra-low dose photon-counting CT: Assessing stability of radiomics features with a patient-based lung
phantom. ECR 2024, Vienna. : 2024.
Im JY, Halliburton SS, Mei K, Perkins AE, Wong E, Roshkovan L, Gang GJ, Noël PB.: Lifelike PixelPrint phantoms for assessing clinical image quality and dose reduction capabilities of a deep learning CT reconstruction algorithm Proc SPIE Int Soc Opt Eng : 2024.
Majumder S, Katz S, Kontos D, Roshkovan L.: State of the art: radiomics and radiomics-related artificial intelligence on the road to clinical translation
BJR Open. 2023 Dec 12;6(1):tzad004.
: 2024.
Apurva Singh, Hannah Horng, Leonid Roshkovan, Charu Aggarwal, Erica L. Carpenter, , Sharyn I. Katz, Despina Kontos.: Exploring the biological significance of a robust radiomic
biomarker of tumor heterogeneity in advanced non-small cell lung cancer patients treated with first-line immunotherapy. RSNA 2023, Chicago. : 2023.
Academic Contact Information
Department of Radiology
Hospital of the University of Pennsylvania
1 Silverstein Building, 3400 Spruce Street
Philadelphia,
PA
19104
Phone: 215-662-3036