Description of Research Expertise

Research Interests: HLA genes and molecules in clinical transplantation

Keywords: Human immunogenetics, HLA genes and molecules. Clinical Histocompatibility, clinical transplantation, autoimmunity.

Research Summary:

Dr. Kamoun's research interest is to define the extent and nature of HLA haplotype genetic diversity and to understand the biological relevance of amino acid polymorphism in HLA class I and class II molecules. Computational and biostatical methods are used to evaluate the significance of HLA amino acid polymorphism in clinical transplantation and autoimmunity.

Another interest is to better understand the impact of B cell alloresponse and anti-HLA antibodies on allograft outcomes in clinical transplantation including islet cell transplantation. Clinical trials are used to assess the effectiveness of B cell depleting agents on alloantibody levels and allograft survival in transplant recipients.

Selected Publications

Kamoun M, Holmes JH, Israni AK, Kearns JD, Teal V, Yang WP, Rosas SE, Joffe MM, Li H, Feldman HI: HLA-A amino acid polymorphism and delayed kidney allograft function Proc Natl Acad Sci U S A 105 (48): 18883-8,2008.

Nikaein A, Cherikh W, Nelson K, Baker T, Leffell S, Bow L, Crowe D, Connick K, Head MA, Kamoun M, Kimball P, Klohe E, Noreen H, Rebellato L, Sell T, Sullivan K, Land G: Organ Procurement and Transplantation Network/United Network for Organ Sharing Histocompatibility Committee collaborative study to evaluate prediction of crossmatch results in highly sensitized patients Transplantation 87 (4): 557-62,2009.

Harris RA, Sugimoto K, Kaplan DE, Ikeda F, Kamoun M, Chang KM: Human leukocyte antigen class II associations with hepatitis C virus clearance and virus-specific CD4 T cell response among Caucasians and African Americans Hepatology 48 (1): 70-9,2008.

Sutter JA, Kwan-Morley J, Dunham J, Du YZ, Kamoun M, Albert D, Eisenberg RA, Luning Prak ET: A longitudinal analysis of SLE patients treated with rituximab (anti-CD20): factors associated with B lymphocyte recovery Clin Immunol 126 (3): 282-90,2008.

Goral S, Prak EL, Kearns J, Bloom RD, Pierce E, Doyle A, Grossman R, Naji A, Kamoun M: Preformed donor-directed anti-HLA-DP antibodies may be an impediment to successful kidney transplantation Nephrol Dial Transplant 23 (1): 390-2,2008.

Kamoun M, Israni AK, Joffe MM, Hoy T, Kearns J, Mange KC, Feldman D, Goodman N, Rosas SE, Abrams JD, Brayman KL, Feldman HI: Assessment of differences in HLA-A, -B, and -DRB1 allele mismatches among African-American and non-African-American recipients of deceased kidney transplants Transplant Proc 39 (1): 55-63,2007.

Rickels MR, Kamoun M, Kearns J, Markmann JF, Naji A: Evidence for allograft rejection in an islet transplant recipient and effect on beta-cell secretory capacity J Clin Endocrinol Metab 92 (7): 2410-4,2007.

Monos D, Heliopoulos J, Argyris E, Cordopatis P, Zompra A, Kamoun M: Analysis of the CD2 and spliceosomal Sm B/B' polyproline-arginine motifs defined by a monoclonal antibody using a phage-displayed random peptide library J Mol Recognit 19 (6): 535-41,2006.

Narula S, LaRosa DF, Kamoun M, Dalmau J, Levinson AI: Progressive multifocal leukoencephalopathy in a patient with common variable immunodeficiency and abnormal CD8+ T-cell subset distribution Ann Allergy Asthma Immunol 98 (5): 483-9,2007.

Luning Prak ET, Young DS, Kamoun M, Nachamkin I, Alexander CB, Spitalnik SL, Peerschke EI, Smith BR: 2008 ACLPS panel discussion on resident education in clinical pathology Am J Clin Pathol 131 (5): 618-22,2009.

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Academic Contact Information

Hospital of the University of Pennsylvania
7.020 Founders Pavilion
3400 Spruce St.
Philadelphia, PA 19104-4238
Phone: 215-614-1902