Description of Research Expertise
My lab’s primary research goals are directed towards understanding the genetic, cellular, and mechanical mechanisms that regulate normal development, disease, and repair of dense connective tissues. I am particularly interested in identifying markers that define resident progenitors vs. mature cell types and the environmental cues (molecular and mechanical) that regulate their differentiation. I was awarded a K99/R00 grant in 2015 to define the tendon cell lineage and pathways that regulate tenogenesis, which led to our current work investigating the role of hedgehog signaling in tendon-to-bone repair and developing novel drug delivery systems targeting this pathway to improve repair outcomes. My lab also examines how mechanical forces impact the formation and maintenance of dense connective tissues. Ultimately, the long-term goals of my lab are directed towards translating these mechanistic studies to novel therapeutic strategies.
Selected Publications
Yuqi Zhang, Meghan E. Kupratis, Giorgos Kotsaris, Nathaniel Dyment, Lin Han, Eiki Koyama, Robert L. Mauck: Altered Transcriptional Landscape And Emergent Region-dependent Mechano-response In The Developing Porcine Meniscus Orthopaedic Research Society Annual Meeting : 2025.
Nat A. Thurlow, Jeremy D. Eekhoff, Meera Ratnagiri, Courtney A. Nuss, Stephanie N. Weiss, Nathaniel A. Dyment, Louis J. Soslowsky: Coordination Of Collagens V And XI Guide Fibril Assembly During Mouse Patellar Tendon Postnatal Development Orthopaedic Research Society Annual Meeting : 2025.
Zizhao Li, Se-Hwan Lee, Ellen Y. Zhang, Marina Santos, Lin Xu, Ruqiang Lu, Dong Hwa Kim, Jaeun Jung, Jayden Shin, Richard Tran, Nathaniel Dyment, Thomas Schaer, Su Chin Heo: A Multiphasic ECM Scaffold System For Rotator Cuff Repair With Tailored Stiffness And Structure For Enhanced Regeneration Orthopaedic Research Society Annual Meeting : 2025.
Meghan E. Kupratis, Yuqi Zhang, Jiaqi Xiang, Bryan Kwok, Nathaniel A. Dyment, Lin Han, Eiki Koyama, Robert L. Mauck: Morphogenesis And Mechano-response Of The Developing Porcine Meniscus Orthopaedic Research Society Annual Meeting : 2025.
Jiaqi Xiang, Bryan Kwok, Mingyue Fan, Meghan E. Kupratis, Sara Tufa, Douglas R. Keene, Robert L. Mauck, Nathaniel A. Dyment, Eiki Koyama, Lin Han: Distinct Molecular And Structural Traits Of Permanent Versus Transient Cartilage In Early Development Orthopaedic Research Society Annual Meeting : 2025.
Qi He, Hanli Guo, Yuewei Lin, Kyu Sang Joeng, Ernestina Schipani, Nathaniel A Dyment, Ivo Kajazic, Ling Qin: Bone Marrow Late Mesenchymal Progenitors Regulate Bone Remodeling, Hematopoiesis, And Vasculature Orthopaedic Research Society Annual Meeting : 2025.
Mary Kate Evans, Ellie Bernstein, Ngoc Khanh Hoang, Jiaqi Xiang, Ellie Ferguson, Tonia Tsinman, Xi Jiang, Lin Han, Eiki Koyama, Joel Boerckel, Robert Mauck, Nathaniel Dyment: Actomyosin Contractility Is Critical For Cell Organization And Matrix Accrual During Tendon Growth Orthopaedic Research Society Annual Meeting : 2025.
Jacob C. Nixon, Stephanie A. Weiss, Nathaniel A. Dyment, Lou J. Soslowsky: The Temporal Role Of Collagen XII In Mouse Tendon Healing Orthopaedic Research Society Annual Meeting : 2025.
Harrison Cottingham, Camila Reyes, Nathan Campbell, Eric Gutierrez, Gordon Smilanich, Talayah Johnson, Nathaniel Dyment, Chad Carroll: Impact Of Serum Advanced Glycation End-products And RAGE Inhibition On Gene Expression In A Murine Model Of Patellar Tendon Healing Orthopaedic Research Society Annual Meeting : 2025.
Talayah Johnson, Natalie L. Fogarty, Alisia Lin, Bryan Kwok, Tonia K. Tsinman, Xi Jiang, Eiki Koyama, Lin Han, Josh R. Baxter, Robert L. Mauck, Nathaniel A. Dyment: Differential Response Of Neonatal And Adult Limbs To Reduced Loading From Sciatic Nerve Resection Orthopaedic Research Society Annual Meeting : 2025.
Academic Contact Information
McKay Orthopaedic Research Laboratory
330A Stemmler Hall
3450 Hamilton Walk
Philadelphia,
PA
19104-6081
Phone: 215-746-8138