Description of Research Expertise

Dr. Meyer identifies genetic and molecular risk factors for acute respiratory distress syndrome (ARDS) and organ dysfunction during sepsis to better understand the pathophysiology of these conditions and to seek novel treatments. The goal of her work is to develop personalized therapy for sepsis and ARDS. Her research program includes:

1) A large observational cohort of critically ill subjects with sepsis including COVID-19 pneumonia phenotyped for infection subtype, comorbidities, survival, ARDS, acute kidney injury (AKI), and cognitive impairment
2) Discovery and validation of genetic and molecular risk factors for sepsis-associated organ dysfunction
3) Clinical trials for ARDS and sepsis [Active: iSPY COVID; CHILL cooling to heal injured lungs]

Selected Publications

Mathew, D., Giles, J. R., Baxter, A. E., Oldridge, D. A., Greenplate, A. R., Wu, J. E., Alanio, C., Kuri-Cervantes, L., Pampena, M. B., D'Andrea, K., Manne, S., Chen, Z., Huang, Y. J., Reilly, J. P., Weisman, A. R., Ittner, C. A. G., Kuthuru, O., Dougherty, J., Nzingha, K., Han, N., Kim, J., Pattekar, A., Goodwin, E. C., Anderson, E. M., Weirick, M. E., Gouma, S., Arevalo, C. P., Bolton, M. J., Chen, F., Lacey, S. F., Ramage, H., Cherry, S., Hensley, S. E., Apostolidis, S. A., Huang, A. C., Vella, L. A., U. Penn COVID Processing Unit, Betts*, M. R., Meyer*, N. J., Wherry*, E. J. (*co-senior author): Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications Science 369 (6508): eabc8511,2020.

Kuri-Cervantes, L., Pampena, M. B., Meng, W., Rosenfeld, A. M., Ittner, C. A. G., Weisman, A. R., Agyekum, R. S., Mathew, D., Baxter, A. E., Vella, L. A., Kuthuru, O., Apostolidis, S. A., Bershaw, L., Dougherty, J., Greenplate, A. R., Pattekar, A., Kim, J., Han, N., Gouma, S., Weirick, M. E., Arevalo, C. P., Bolton, M. J., Goodwin, E. C., Anderson, E. M., Hensley, S. E., Jones, T. K., Mangalmurti, N. S., Luning Prak, E. T., Wherry*, E. J., Meyer*, N. J., Betts*, M. R. (*co-senior author): Comprehensive mapping of immune perturbations associated with severe COVID-19 Sci Immunol 5 (49): eabd7114,2020.

Guillen-Guio Beatriz, Lorenzo-Salazar Jose M, Ma Shwu-Fan, Hou Pei-Chi, Hernandez-Beeftink Tamara, Corrales Almudena, García-Laorden M Isabel, Jou Jonathan, Espinosa Elena, Muriel Arturo, Domínguez David, Lorente Leonardo, Martín María M, Rodríguez-Gallego Carlos, Solé-Violán Jordi, Ambrós Alfonso, Carriedo Demetrio, Blanco Jesús, Añón José M, Reilly John P, Jones Tiffanie K, Ittner Caroline Ag, Feng Rui, Schöneweck Franziska, Kiehntopf Michael, Noth Imre, Scholz Markus, Brunkhorst Frank M, Scherag André, Meyer Nuala J, Villar Jesús, Flores Carlos: Sepsis-associated acute respiratory distress syndrome in individuals of European ancestry: a genome-wide association study. The Lancet. Respiratory medicine 8 (3): 258-266,2020.

Reilly John P, Wang Fan, Jones Tiffanie K, Palakshappa Jessica A, Anderson Brian J, Shashaty Michael G S, Dunn Thomas G, Johansson Erik D, Riley Thomas R, Lim Brian, Abbott Jason, Ittner Caroline A G, Cantu Edward, Lin Xihong, Mikacenic Carmen, Wurfel Mark M, Christiani David C, Calfee Carolyn S, Matthay Michael A, Christie Jason D, Feng Rui, Meyer Nuala J: Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis. Intensive care medicine 44 (11): 1849-1858,2018.

Meyer Nuala J, Reilly John P, Anderson Brian J, Palakshappa Jessica A, Jones Tiffanie K, Dunn Thomas G, Shashaty Michael G S, Feng Rui, Christie Jason D, Opal Steven M: Mortality Benefit of Recombinant Human Interleukin-1 Receptor Antagonist for Sepsis Varies by Initial Interleukin-1 Receptor Antagonist Plasma Concentration. Critical care medicine 46 (1): 21-28,2018.

Reilly, John P.; Meyer, Nuala J.; Shashaty, Michael G.S.; Anderson, Brian J.; Ittner, Caroline A.G.; Dunn, Thomas G.; Lim, Brian; Forker, Caitlin; Bonk, Michael P.; Kotloff, Ethan D.; Feng, Rui; Cantu, Edward;, Mangalmurti, Nilam S.; Calfee, Carolyn S.; Matthay, Michael A.; Mikacenic, Carmen; Walley, Keith R.; Russell, James A.; Christiani, David C.; Wurfel, Mark M.; Lanken, Paul N.; Reilly, Muredach P.; Christie, Jason D.: The ABO Histo-Blood Group, endothelial activation, and acute respiratory distress syndrome risk in critical illness J Clin Invest 131 (1): e139700,2021.

Jones Tiffanie K, Feng Rui, Kerchberger V Eric, Reilly John P, Anderson Brian J, Shashaty Michael G S, Wang Fan, Dunn Thomas G, Riley Thomas R, Abbott Jason, Ittner Caroline A G, Christiani David C, Mikacenic Carmen, Wurfel Mark M, Ware Lorraine B, Calfee Carolyn S, Matthay Michael A, Christie Jason D, Meyer Nuala J: Plasma sRAGE Acts as Genetically Regulated Causal Intermediate in Sepsis-Associated ARDS. American journal of respiratory and critical care medicine 201 (1): 47-56,2020.

Meyer Nuala J, Reilly John P, Feng Rui, Christie Jason D, Hazen Stanley L, Albert Carolyn J, Franke Jacob D, Hartman Celine L, McHowat Jane, Ford David A: Myeloperoxidase-derived 2-chlorofatty acids contribute to human sepsis mortality via acute respiratory distress syndrome. JCI insight 2 (23): e96432,2017.

Meyer Nuala J, Calfee Carolyn S: Novel translational approaches to the search for precision therapies for acute respiratory distress syndrome. The Lancet. Respiratory medicine 5 (6): 512-523,2017.

Palakshappa Jessica A, Meyer Nuala J: Which Patients with ARDS Benefit from Lung Biopsy? Chest 148 (4): 1073-1082,2015.

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Academic Contact Information

Division of Pulmonary and Critical Care Medicine
Hospital of the University of Pennsylvania
3400 Spruce Street
5037 Gates Building
Philadelphia, PA 19104
Phone: 215-662-7049
Patient appointments: 800-789-7366