Description of Research Expertise

My research interests center around the study of the complications of HIV and its treatment, and currently in the evaluation of strategies for the cure of HIV infection.
I am the director and the PI of the AIDS clinical trial unit of the University of Pennsylvania.
I am one of the founding members of the HIV Reservoirs and Viral Eradication (Cure) Transformative Science Group (TSG) of the AIDS clinical trial group. In addition to my ACTG work, I am involved (as PI of the clinical project) in several early phase trials of new compounds developed in conjunction with the NIH in several IPCP grants, including a Phase I study evaluating the antiviral activity of aprepitant (an NK-1R antagonist that down-regulates the expression of CCR5), a phase I study evaluating the immunogenicity of a therapeutic DNA vaccine administered by intramuscular electroporation in collaboration with David Weiner and several gene therapy studies evaluating the therapeutic use of lentiviral vectors in the management of HIV infection (including the use of VIRxSYS 496 –antisense approach-, the first in humans Sangamo’s zinc finger nuclease for CCR5 edition, in collaboration with Dr. Carl June.

Selected Publications

Board, N. L., Yuan, Z., Wu, F., Moskovljevic, M., Ravi, M., Sengupta, S., Mun, S. S., Simonetti, F. R., Lai, J., Tebas, P., Lynn, K., Hoh, R., Deeks, S. G., Siliciano, J. D., Montaner, L. J., Siliciano, R. F.: Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells Nat Immunol : 2024.

Jacobson, J. M., Felber, B. K., Chen, H., Pavlakis, G. N., Mullins, J. I., de Rosa, S. C., Kuritzkes, D. R., Tomaras, G. D., Kinslow, J., Bao, Y., Olefsky, M., Rosati, M., Bear, J., Hannaman, D., Laird, G. M., Cyktor, J. C., Heath, S. L., Collier, A. C., Koletar, S. L., Taiwo, B. O., Tebas, P., Wohl, D. A., Belanzauran-Zamudio, P. F., McElrath, M. J., Landay, A. L., Actg Study Team: The immunogenicity of an HIV-1 gag conserved element DNA vaccine in people with HIV and receiving antiretroviral therapy AIDS : 2023.

Bilger, A., Plenn, E., Barg, F. K., Rendle, K. A., Carter, W. B., Lamour-Harrington, A., Jones, N., Peterson, B., Sauceda, J. A., Tebas, P., Mounzer, K., Metzger, D., Montaner, L. J., Dube, K.: Participant experiences in HIV cure-directed trial with an extended analytical treatment interruption in Philadelphia, United States HIV Res Clin Pract 24 (1): 2267825,2023.

Anesi, G. L., Degnan, K., Dutcher, L., Saw, S., Maguire, C., Binkley, A., Patel, S., Athans, V., Barton, T. D., Binkley, S., Candeloro, C. L., Herman, D. J., Kasbekar, N., Kennedy, L., Millstein, J. H., Meyer, N. J., Talati, N. J., Patel, H., Pegues, D. A., Sayre, P. J., Tebas, P., Terico, A. T., Murphy, K. M., O'Donnell, J. A., White, M., Hamilton, K. W.: The Penn Medicine COVID-19 Therapeutics Committee-Reflections on a Model for Rapid Evidence Review and Dynamic Practice Recommendations During a Public Health Emergency Open Forum Infect Dis 10 (8): ofad428,2023.

McMyn, N. F., Varriale, J., Fray, E. J., Zitzmann, C., MacLeod, H. J., Lai, J., Singhal, A., Moskovljevic, M., Garcia, M. A., Lopez, B. M., Hariharan, V., Rhodehouse, K., Lynn, K., Tebas, P., Mounzer, K., Montaner, L. J., Benko, E., Kovacs, C., Hoh, R., Simonetti, F. R., Laird, G. M., Deeks, S. G., Ribeiro, R. M., Perelson, A. S., Siliciano, R., Siliciano, J. M.: The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy J Clin Invest : 2023.

Mamidi, R. S., Ayubcha, C., Rigney, G., Kirschner, J., Gerke, O., Werner, T. J., Tebas, P., Alavi, A., Revheim, M. E.: A prospective 18 F-fluorodeoxyglucose positron emission tomography/computed tomography study of the neurometabolic effects in cocaine use and HIV infection AIDS 37 (6): 905-912,2023.

Tebas, P., Lynn, K., Azzoni, L., Cocchella, G., Papasavvas, E., Fair, M., Karanam, B., Sharma, P., Reeves, J. D., Petropoulos, C. J., Lalley-Chareczko, L., Kostman, J. R., Short, W., Mounzer, K., Montaner, L. J.: Susceptibility to 3BNC117 and 10-1074 in ART suppressed chronically infected persons AIDS : 2023.

Hait, S.H., Shrader, H., Lovelace, S., Coates, E., Rothwell, R.S., Donaghy, E., Fichtenbaum, C.J., Santana, J., Presti, R., Roa, J., Bhatnagar, A., Lynch, R.M., Tebas, P., Mascola, J.R., Pegu, A.: Efficacy and Complementarity of HIV-1 Suppression by CD4-Binding bNAbs 30th Conference on Retrovirus and Oppotunistic infections. February 19-22, 2022 Seattle, Abstract #307 : 2023.

Molina, J.-M., Rizzardini, G., Orrell, C., Saud, A.A., Calmy, A., Oka, S., Hinestrosa, F., Kumar, P., Tebas, P., Walmsley, S., Grandhi, A., Gendrano, I.N., Eves, K., Kim, J., Correll, T.A.: Switch to DOR/ISL (100/0.75mg) Qd: Week 48 Results from an Open-Label Phase 3 Trial 30th Conference on Retrovirus and Oppotunistic infections. February 19-22, 2022 Seattle, Abstract #196 : 2023.

Joy, J., Marino, F., Krause, R., Petropoulos, C.J., Papasavvas, E., Fair, M., Mounzer, K., Tebas, P., Montaner, L.J., Bar, K.J.: BEAT2: Peg-IFN-Alpha + 3BNC117 & 10-1074 Rebound Virus Phenotype and Evolution 30th Conference on Retrovirus and Oppotunistic infections. February 19-22, 2022 Seattle, Abstract #326 : 2023.

Academic Contact Information

Academic Address: 502 Johnson Pavilion
Clinical Office: 4 Perelman Center for Advanced Medicine, 3600 Civic Center Boulevard
Philadelphia, PA 19104
Phone: 215-349-8092
Patient appointments: 800-789-7366