Description of Research Expertise

For over a decade Dr. Noël directs a research program with a broad focus on developing x-ray and Computed Tomography (CT) technology. A central component of his research is the harmonization between hardware and software, reconstruction, and post-processing to achieve integrated clinical solutions. He has built an extensive foundation for facilitating the clinical translation of novel diagnostic imaging technology; one example is the introduction of photon-counting CT. A parallel effort is the development of novel 3D printed CT phantoms, which serve as a central ingredient for clinical and research tasks around evaluation and standardization. Recently he and his team introduced patient-specific lung phantoms, which are available to the larger research community. On the other end of the spectrum, his research program contributes to basic x-ray physics questions focusing on phase-contrast and dark-field imaging. His publication record not only includes more than 190 peer-reviewed publications in international journals, but also a patent portfolio in the areas of x-ray and CT imaging.

Selected Publications

Sandvold, O. F., Proksa, R., Daerr, H., Perkins, A. E., Brown, K. M., Koehler, T., Manjeshwar, R. M., & Noel, P. B.: A computationally efficient method for dimensionality reduction in multi-channel spectral CT. medRxiv : 2024.

Shunhavanich, P., Mei, K., Shapira, N., Stayman, J. W., McCollough, C. H., Gang, G., Noël, P. B., & Hsieh, S. S.: 3D printed phantom with 12 000 submillimeter lesions to improve efficiency in CT detectability assessment. Medical physics : 2024.

Im, J. Y., Halliburton, S., Mei, K., Perkins, A. E., Wong, E., Roshkovan, L., Sandvold, O. F., Liu, L. P., Gang. G. J., & Noël, P. B.: Patient-derived PixelPrint phantoms for evaluating clinical imaging performance of a deep learning CT reconstruction algorithm. Physics in Medicine and Biology : 2024.

Liu, L. P., Pua, R., Dieckmeyer, M., Shapira, N., Sahbaee, P., Gang, G. J., Litt, H., & Noël, P. B.: Impact of patient habitus and acquisition protocol on iodine quantification in dual source photon-counting CT Journal of Medical : 2024.

Liu, L. P., Pua, R., Rosario-Berrios, D. N., Sandvold, O. F., Perkins, A. E., Cormode, D. P., Shapira, N., Soulen, M., & Noël, P. B.: Reproducible spectral CT thermometry with liver-mimicking phantoms for image-guided thermal ablation. Physics in Medicine & Biology : 2024.

Rosario-Berrios, D. N., Pang, A., Liu, L., Maidment, P. S., Kim, J., Yoon, S., Nieves, L. M., Mossburg, K., Adezio, A., Noël, P. B., Lennon, E. M., & Cormode, D. P.: The effect of the size of gold nanoparticle contrast agents on CT imaging of the gastrointestinal tract and inflammatory bowel disease. bioRxiv : 2024.

Liu, L. P., Pasyar, P., Liu, F., Cao, Q., Sandvold, O. F., Sahbaee, Shinohara, T., P., Litt, H. I., & Noël, P. B.: Assessing the Stability of Photon-Counting CT: Insights from a Two-Year Longitudinal Study. medRxiv : 2024.

Liu, L. P., & Noël, P. B.: In Regards to Baubeta et al. Journal of Applied Clinical Medical Physics : 2024.

Salazar, E., Liu, L. P., Perkins, A. E., Halliburton, S. S., Shapira, N., Litt, H. I., & Noël, P. B.: Impact of scatter radiation on spectral quantification performance of first‐and second‐generation dual‐layer spectral computed tomography. Journal of Applied Clinical Medical Physics : 2024.

Im, J. Y., Micah, N., Perkins, A. E., Mei, K., Geagan, M., & Noël, P. B.: PixelPrint4D: A 3D printing method of fabricating patient-specific deformable CT phantoms for respiratory motion applications. medRxiv : 2024.

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Academic Contact Information

Hospital of the University of Pennsylvania
Department of Radiology
3400 Spruce Street, One Silverstein


Philadelphia, PA 19104