Description of Research Expertise

For over a decade Dr. Noël directs a research program with a broad focus on developing x-ray and Computed Tomography (CT) technology. A central component of his research is the harmonization between hardware and software, reconstruction, and post-processing to achieve integrated clinical solutions. He has built an extensive foundation for facilitating the clinical translation of novel diagnostic imaging technology; one example is the introduction of photon-counting CT. A parallel effort is the development of novel 3D printed CT phantoms, which serve as a central ingredient for clinical and research tasks around evaluation and standardization. Recently he and his team introduced patient-specific lung phantoms, which are available to the larger research community. On the other end of the spectrum, his research program contributes to basic x-ray physics questions focusing on phase-contrast and dark-field imaging. His publication record not only includes more than 190 peer-reviewed publications in international journals, but also a patent portfolio in the areas of x-ray and CT imaging.

Selected Publications

Rosario-Berríos DN, Pang A, Liu LP, Maidment PSN, Kim J, Yoon S, Nieves LM, Mossburg KJ, Adezio A, Noël PB, Lennon EM, Cormode DP: The Effect of the Size of Gold Nanoparticle Contrast Agents on CT Imaging of the Gastrointestinal Tract and Inflammatory Bowel Disease Bioconjug Chem 36 (2): 233-244,2025.

Liu, L. P., Pasyar, P., Liu, F., Cao, Q., Sandvold, O. F., Sahbaee, Shinohara, T., P., Litt, H. I., & Noël, P. B.: Assessing the Stability of Photon-Counting CT: Insights from a Two-Year Longitudinal Study European Radiology : 2024.

Liu, L. P., Pua, R., Dieckmeyer, M., Shapira, N., Sahbaee, P., Gang, G. J., Litt, H., & Noël, P. B.: Impact of patient habitus and acquisition protocol on iodine quantification in dual source photon-counting CT Journal of Medical Imaging (Bellingham) 11 (Suppl 1): S12806,2024.

Salazar, E., Liu, L. P., Perkins, A. E., Halliburton, S. S., Shapira, N., Litt, H. I., & Noël, P. B.: Impact of scatter radiation on spectral quantification performance of first- and second-generation dual-layer spectral computed tomography Journal of Applied Clinical Medical Physics 25 (7): e14383,2024.

Im, J. Y., Halliburton, S., Mei, K., Perkins, A. E., Wong, E., Roshkovan, L., Sandvold, O. F., Liu, L. P., Gang. G. J., & Noël, P. B.: Patient-derived PixelPrint phantoms for evaluating clinical imaging performance of a deep learning CT reconstruction algorithm Physics in Medicine and Biology 69 (11): 115009,2024.

Shunhavanich, P., Mei, K., Shapira, N., Stayman, J. W., McCollough, C. H., Gang, G., Noël, P. B., & Hsieh, S. S.: 3D printed phantom with 12 000 submillimeter lesions to improve efficiency in CT detectability assessment. Medical physics 51 (5): 3265-3274,2024.

Liu, L. P., Shapira, N., Halliburton, S. S., Meyer, S., Perkins, A., Litt, H. I., Kauczor, H.U., Leiner, T., Stiller, W., & Noël, P. B.: Spectral performance evaluation of a second-generation spectral detector CT.  Journal of Applied Clinical Medical Physics 25 (4): e14300,2024.

Liu, L. P., Pua, R., Rosario-Berrios, D. N., Sandvold, O. F., Perkins, A. E., Cormode, D. P., Shapira, N., Soulen, M., & Noël, P. B.: Reproducible spectral CT thermometry with liver-mimicking phantoms for image-guided thermal ablation Physics in Medicine & Biology 69 (4): 045009,2024.

Donuru, A., Araki, T., Dako, F., Dave, J. K., Perez, R. P., Xu, D., Nachiapan, A., Barbosa, E. M., Noël, P. B., Litt, H., & Knollman, F.: Photon-counting detector CT allows significant reduction in radiation dose while maintaining image quality and noise on non-contrast chest CT European Journal of Radiology Open 11 : 100538,2023.

Sauter, A. P., Proksa, R., Knipfer, A., Reischl, S., Braren, R. F., Nadjiri, J., Kopp, K., Noël, P. B., Makowski, M., Rummeny, E. J., & Fingerle, A. A.: CT-Guided Liver Biopsy: Evaluation of Spectral Data From Dual-Layer Detector CT for Improved Lesion Detection Cardiovascular and Interventional Radiology 46 (11): 1621-1631,2023.

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Academic Contact Information

Hospital of the University of Pennsylvania
Department of Radiology
3400 Spruce Street, One Silverstein


Philadelphia, PA 19104