Description of Research Expertise
My major research interests are as follows:
1) To investigate the molecular recognition mechanism of opioids and their receptors using biophysical, biochemical, thermodynamic, protein engineering, and high-resolution structural approaches.
2) Pharmacological effects of opioid receptor agonists.
3) Anesthetic interaction with proteins
4) Preoperative evaluation and outcome
Selected Publications
Ji F, Wang Z, Ma N, Riley J, Armstead WA, Liu R: Herkinorin dilates cerebral vessels via kappa opioid receptor and cyclic adenosine monophosphate (cAMP) signalling in a piglet model Brain Res 1490 : 95-100,2013.
Perez-Aguilar JM, Saven JG, Liu R: Human µ opioid receptor models with evaluation of the accuracy using the crystal structure of the murine µ opioid receptor. J Anesth Clin Res 3 (218): doi:10.4172/2155-6148.1000218,2012.
Bu W, Liu R, Cheung-Lau JC, Dmochowski IJ, Loll PJ, Eckenhoff RG: Ferritin couples iron and fatty acid metabolism FASEB J 26 (6): 2394-23400,2012.
Liu R, Bu W, Xi J, Mortazavi SR, Cheung-Lau J, Dmochowski IJ, Loll PJ: Beyond the detergent effect: A binding site for sodium dodecyl sulfate (SDS) in mammalian apoferritin Acta Crystallogr D Biol Crystallogr 68 (5): 497-504,2012.
Liu R, Perez-Aguilar JM, Liang D, Saven JG: Binding site and affinity prediction of general anesthetics to protein targets using docking Anesth Analg 114 (5): 947-955,2012.
Liu R, Garcia PS, Fleisher LA: Interest in anesthesia as reflected by keyword searches using common search engines J Anesth Clin Res 3 (1): 192. DOI: 10.4172/2155- 6148.1000192,2012.
Oakley S, Vedula S, Bu W, Xi J, Liu R, Eckenhoff RG, Loll PJ: Recognition of anesthetic barbiturates by a protein binding site: A high
resolution structural analysis PLoS One 7 (2): e32070,2012.
Wang Z, Ma N, Rily J, Armstead WA, Liu R: Salvinorin A administration after global cerebral hypoxia/ischemia preserves cerebrovascular autoregulation via kappa opioid receptor in piglets PLoS One 7 (7): e41724,2012.
Yan Z, Tanner JW, Lin D, Chalian AA, Savino JS, Fleisher LA, Liu R: Airway trauma in an academic cardiac electrophysiology laboratory center with high patient volume Anesth Analg 116 (1): 112-117,2013.
Su D, Reiley J, Armstead W, Liu R: Salvinorin A dilates pial artery by activating NOS, opioid receptor and the KATP channel Anesthesiology : A713,2010.
Su D, Riley J, Kiessling WJ, Armstead WM, Liu R: Salvinorin A pretreatment preserves cerebrovascular autoregulation after brain hypoxic/ischemic injury via ERK/MAPK in piglets Anesth Anal 114 (1): 200-204,2011.
Zhou R, Perez-Aguilar JM, Meng Q, Saven JG, Liu R: Opioid binding sites in human serum albumin Anesth Analg 114 (1): 122-128,2012.
Su D, Riley J, Kiessling WJ, Armstead WM, Liu R: Salvinorin A produces cerebrovasodilation through activation of nitric oxide synthase, κ receptor, and adenosine triphosphate-sensitive potassium channel Anesthesiology 114 (2): 374-379,2011.
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Academic Contact Information
Department of Anesthesiology and Critical Care
336 John Morgan Building
3620 Hamilton Walk
Philadelphia,
PA
19104
Phone: 215-746-1485