Penn Medicine Provider
Roger A. Greenberg, MD, PhD

About me

  • Director, Penn Center for Genome Integrity
  • J. Samuel Staub, M.D. Professor

Insurance accepted

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Qualifications and experience

Treatments and Conditions

My research

Krishnamoorthy V#, Foglizzo M#, Dilley RL#*, Wu A, Datta A, Dutta P, Campbell LJ, Degtjarik O, Musgrove LJ, Calabrese AN, Zeqiraj E*, and Greenberg RA*. The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity , Cell, 187(9): 2024,2250-2268


Jiang H*, Zhang T*, Kaur H, Shi T, Krishnan A, Kwon Y, Sung P, and Greenberg RA BLM helicase unwinds lagging strand substrates to assemble the ALT telomere damage response , Molecular Cell, 84(9): 2024,1684-1698


Tianpeng Zhang, Yashpal Rawal, Haoyang Jiang, Youngho Kwon, Patrick Sung & Roger A. Greenberg Break-induced replication orchestrates resection-dependent template switching , Nature, 619(7968): 2023,201-208


Francesca Chandler, Poli Adi Narayana Reddy, Smita Bhutda, Rebecca L., Ross, Arindam Datta, Miriam Walden, Kieran Walker, Stefano Di Donato, Joel A. Cassel, Michael A. Prakesch, Ahmed Aman, Alessandro Datti, Lisa J. Campbell, Martina Foglizzo, Lillie Bell, Daniel N. Stein, James R. Ault, Rima S. Al-awar, Antonio N. Calabrese, Frank Sicheri, Francesco Del Galdo*, Joseph M. Salvino*, Roger A. Greenberg* and Elton Zeqiraj* Molecular glues that inhibit deubiquitylase activity and inflammatory signalling , Nature Structural & Molecular Biology: 2025


Jiang Q, Foglizzo M, Morozov YI, Yang X, Datta A, Tian L, Thada V, Li W, Zeqiraj E and Greenberg RA. Autologous K63-deubiquitylation within the BRCA1-A complex licenses DNA damage recognition , J. Cell Biol. , 221(9): 2022,e202111050


Verma P, Zhou Y, Cao Z, Deraska PV, Deb M, Arai E, Li W, Shao Y, Li Y, Puentes L, Patankar S, Mach RH, Faryabi RB, Shi Y*, and Greenberg RA* ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination deficient cells , Nature Cell Biology: 2021


Walden M*, Tian L*, Ross R, Sykora UM, Byrne DP, Hesketh EL, Masandi SK, Cassel J, Geirge R, Ault JR, Oualid FE, Pawlowski K, Salvino JM, Eyers PA, Ranson NA, Del Galdo F, Greenberg RA#, Zeqiraj E# Metabolic control of BRISC-SHMT2 assembly regulates immune signaling. , Nature, 10.1038/s41586-019-1232-1: 2019


Harding SM, Benci JL, Irianto J, Discher DE, Minn AJ, Greenberg RA Mitotic progression following DNA damage enables pattern recognition within micronuclei , Nature, 548: 2017,466-470


Dilley RL, Verma P, Cho NW, Winters HD, Wondisford AR, and Greenberg RA Break-Induced Telomere Synthesis Underlies Homology-Directed Telomere Maintenance , Nature, 539(7627): 2016,54-58


Cho NW, Dilley RL, Lampson MA, Greenberg RA Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis , Cell, 159(1): 2014,108-21


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