About me
- Director, Penn Center for Genome Integrity
- J. Samuel Staub, M.D. Professor
My Locations
Qualifications and experience
- AACR, National
- AACR Distinguished Lectureship in Breast Cancer Research Award selection committee, National
- American Association for Cancer Research, National
- American Association of Physicians, National
- American Society of Clinical Investigation, National
- Cancer Research UK Investigator Review, International
- Chair of External Advisory Board for Washington University in St. Louis Medical School Program Project Grant in DNA damage responses, National
- Co-Founder and Scientific Advisory Board, JAMM Therapeutics, International
- Co-Founder and Scientific Advisory Board, RADD Pharmaceuticals, Boston MA, International
- Dong-A ST, International
- Dong-A ST Pharmaceuticals, International
- External Advisory Board, Memorial Sloan Kettering Cancer Center Breast SPORE, National
- Scientific Advisory Board Member, Trevarx Biomdical Inc., National
- University of Texas Health Science Center at San Antonio, P01 external advisory board, National
- Washington University of St. Louis School of Medicine, P01 external advisory board, National
- Abramson Cancer Center
Treatments and Conditions
My research
Krishnamoorthy V#, Foglizzo M#, Dilley RL#*, Wu A, Datta A, Dutta P, Campbell LJ, Degtjarik O, Musgrove LJ, Calabrese AN, Zeqiraj E*, and Greenberg RA*. The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity , Cell, 187(9): 2024,2250-2268
Jiang H*, Zhang T*, Kaur H, Shi T, Krishnan A, Kwon Y, Sung P, and Greenberg RA BLM helicase unwinds lagging strand substrates to assemble the ALT telomere damage response , Molecular Cell, 84(9): 2024,1684-1698
Tianpeng Zhang, Yashpal Rawal, Haoyang Jiang, Youngho Kwon, Patrick Sung & Roger A. Greenberg Break-induced replication orchestrates resection-dependent template switching , Nature, 619(7968): 2023,201-208
Francesca Chandler, Poli Adi Narayana Reddy, Smita Bhutda, Rebecca L., Ross, Arindam Datta, Miriam Walden, Kieran Walker, Stefano Di Donato, Joel A. Cassel, Michael A. Prakesch, Ahmed Aman, Alessandro Datti, Lisa J. Campbell, Martina Foglizzo, Lillie Bell, Daniel N. Stein, James R. Ault, Rima S. Al-awar, Antonio N. Calabrese, Frank Sicheri, Francesco Del Galdo*, Joseph M. Salvino*, Roger A. Greenberg* and Elton Zeqiraj* Molecular glues that inhibit deubiquitylase activity and inflammatory signalling , Nature Structural & Molecular Biology: 2025
Jiang Q, Foglizzo M, Morozov YI, Yang X, Datta A, Tian L, Thada V, Li W, Zeqiraj E and Greenberg RA. Autologous K63-deubiquitylation within the BRCA1-A complex licenses DNA damage recognition , J. Cell Biol. , 221(9): 2022,e202111050
Verma P, Zhou Y, Cao Z, Deraska PV, Deb M, Arai E, Li W, Shao Y, Li Y, Puentes L, Patankar S, Mach RH, Faryabi RB, Shi Y*, and Greenberg RA* ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination deficient cells , Nature Cell Biology: 2021
Walden M*, Tian L*, Ross R, Sykora UM, Byrne DP, Hesketh EL, Masandi SK, Cassel J, Geirge R, Ault JR, Oualid FE, Pawlowski K, Salvino JM, Eyers PA, Ranson NA, Del Galdo F, Greenberg RA#, Zeqiraj E# Metabolic control of BRISC-SHMT2 assembly regulates immune signaling. , Nature, 10.1038/s41586-019-1232-1: 2019
Harding SM, Benci JL, Irianto J, Discher DE, Minn AJ, Greenberg RA Mitotic progression following DNA damage enables pattern recognition within micronuclei , Nature, 548: 2017,466-470
Dilley RL, Verma P, Cho NW, Winters HD, Wondisford AR, and Greenberg RA Break-Induced Telomere Synthesis Underlies Homology-Directed Telomere Maintenance , Nature, 539(7627): 2016,54-58
Cho NW, Dilley RL, Lampson MA, Greenberg RA Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis , Cell, 159(1): 2014,108-21