Description of Research Expertise
RESEARCH INTERESTS:
The Drapkin lab is driven by a shared passion for advancing scientific discovery, fostering mentorship, and building a collaborative and inclusive community. Guided by these core values, we are dedicated to unraveling the complexities of ovarian cancer with the goal of transforming patient outcomes.
Our mission is to conduct high-impact research that deepens our understanding of ovarian cancer pathogenesis, genetics, and tumor microenvironment dynamics. We are particularly focused on the origins of high-grade serous ovarian carcinoma (HGSOC), the most lethal subtype of ovarian cancer, and have played a pivotal role in uncovering its roots in the Fallopian tube epithelium. Our innovative approach includes developing and utilizing cutting-edge models, such as genetically engineered mouse models (GEMs), Fallopian tube-derived cell lines, and patient-derived tumor xenografts (PDXs).
We strive to foster an environment where team science thrives—embracing collaboration across disciplines, institutions, and communities to drive innovation. Mentorship is a cornerstone of our lab’s ethos, and we are committed to training the next generation of scientists and clinicians through meaningful engagement and support.
By advancing fundamental knowledge and translating discoveries into actionable strategies, we aim to improve the lives of ovarian cancer patients while inspiring a future where diversity, curiosity, and collective effort empower the next wave of breakthroughs in cancer research.
KEYWORDS: Ovarian cancer, Fallopian tube, Spatial Multi-Omics Pre-Cancer Atlas, Tumor Microenvironment, Tumor Innervation, Cyclin E, BRCA1/2, DNA Repair, Protein complexes, Master Transcription Factors, Biomarkers, Animal models.
ROTATION PROJECTS:
Rotation projects are open to students in each of the areas the lab focuses on. Please see Ronny Drapkin to discuss potential rotation projects.
LAB PERSONNEL:
Yelena Zhuravlev, PhD, Program Manager
Matthew Knarr, PhD, Postdoctoral Researcher
Pamela Rojas de Santiago, PhD, Postdoctoral Researcher
Gabriel Mingo, PhD, Postdoctoral Researcher
Dusan Racordon, PhD, Postdoctoral Researcher
Katherine Cummins, PhD, Postdoctoral Researcher
Camille Mccallister, MD, Gynecologic Oncology Fellow
Sarah Kimmel, Research Specialist
Edwin Sedodo, Research Specialist
Harper Green, Penn undergraduate
Sristhi Chowdhury, Penn undergraduate
ADMINISTRATIVE COORDINATOR:
Denise Curley
215-573-9476
denise.curley@uphs.upenn.edu
Selected Publications
Reavis HD, Gysler SM, McKenney GB, Knarr M, Lusk HJ, Rawat P, Rendulich HS, Mitchell MA, Berger DS, Moon JS, Ryu S, Mainigi M, Iwanicki MP, Hoon DS, Sanchez LM, Drapkin R.: Norepinephrine induces anoikis resistance in high-grade serous ovarian cancer precursor cells. JCI Insight 9 (5): e170961,2024.
Taylor MS, Wu C, Fridy PC, Zhang SJ, Senussi Y, Wolters JC, Cajuso T, Cheng WC, Heaps JD, Miller BD, Mori K, Cohen L, Jiang H, Molloy KR, Chait BT, Goggins MG, Bhan I, Franses JW, Yang X, Taplin ME, Wang X, Christiani DC, Johnson BE, Meyerson M, Uppaluri R, Egloff AM, Denault EN, Spring LM, Wang TL, Shih IM, Fairman JE, Jung E, Arora KS, Yilmaz OH, Cohen S, Sharova T, Chi G, Norden BL, Song Y, Nieman LT, Pappas L, Parikh AR, Strickland MR, Corcoran RB, Mustelin T, Eng G, Yilmaz OH, Matulonis UA, Skates SJ, Rueda BR, Drapkin R, Klempner SJ, Deshpande V, Ting DT, Rout MP, LaCava J, Walt DR, Burns KH: Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker. Cancer Discov 13 (12): 2532-2547,2023.
Balood M, Ahmadi M, Eichwald T, Ahmadi A, Majdoubi A, Roversi K, Roversi K, Lucido CT, Restaino AC, Huang S, Ji L, Huang KC, Semerena E, Thomas SC, Trevino AE, Merrison H, Parrin A, Doyle B, Vermeer DW, Spanos WC, Williamson CS, Seehus CR, Foster SL, Dai H, Shu CJ, Rangachari M, Thibodeau J, V Del Rincon S, Drapkin R, Rafei M, Ghasemlou N, Vermeer PD, Woolf CJ, Talbot S: Nociceptor neurons affect cancer immunosurveillance. Nature 611 (7935): 405-412,2022.
Doberstein K, Spivak R, Reavis HD, Hooda J, Feng Y, Kroeger PT Jr, Stuckelberger S, Mills GB, Devins KM, Schwartz LE, Iwanicki MP, Fogel M, Altevogt P, Drapkin R: L1CAM is required for early dissemination of fallopian tube carcinoma precursors to the ovary. Communications Biology 5 (1): 1362,2022.
Chaves-Moreira D, Mitchell MA, Arruza C, Rawat P, Sidoli S, Nameki R, Reddy J, Corona RI, Afeyan LK, Klein IA, Ma S, Winterhoff B, Konecny GE, Garcia BA, Brady DC, Lawrenson K, Morin PJ, Drapkin R: The transcription factor PAX8 promotes angiogenesis in ovarian cancer through interaction with SOX17. Science Signaling 15 (728): eabm2496,2022.
Gysler SM, Drapkin R: Tumor innervation: peripheral nerves take control of the tumor microenvironment. J Clin Invest 131 (11): 2021.
Hooda J, Novak M, Salomon MP, Matsuba C, Ramos RI, MacDuffie E, Song M, Hirsch MS, Lester J, Parkash V, Karlan BY, Oren M, Hoon DS, Drapkin R: Early loss of Histone H2B monoubiquitylation alters chromatin accessibility and activates key immune pathways that facilitate progression of ovarian cancer. Cancer Research 79 (4): 760-772,2019.
Labidi-Galy SI, Papp E, Hallberg D, Niknafs N, Adleff V, Noe M, Bhattacharya R, Novak M, Jones S, Phallen J, Hruban CA, Hirsch MS, Lin DI, Schwartz L, Maire CL, Tille JC, Bowden M, Ayhan A, Wood LD, Scharpf RB, Kurman R, Wang TL, Shih IM, Karchin R, Drapkin R*, Velculescu VE*., * Co-senior/corresponding authors: High grade serous ovarian carcinomas originate in the fallopian tube. Nature Communications 8 (1): 1093,2017.
Karst AM, Jones PM, Vena N, Ligon AH, Liu JF, Hirsch MS, Etemadmoghadam D, Bowtell DD, Drapkin R: Cyclin E1 deregulation occurs early in secretory cell transformation to promote formation of fallopian tube-derived high-grade serous ovarian cancers. Cancer Res 74 (4): 1141-52,2014.
Perets R, Muto KW, Bijron JG, Poole BB, Chin KT, Kwak S, Chen JYH, Karst AM, Setlur SR, Hirsch MS, Crum CP, Dinulescu DM, Drapkin R: Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models. *Highlighted in Nature Reviews Cancer, Cancer Discovery, and Cancer Research. Cancer Cell 24: 751-65 : 2013.
View all publications
Academic Contact Information
University of Pennsylvania
Biomedical Research Building
421 Curie Blvd., Rm. 1215
Philadelphia,
PA
19104
Phone: 215-746-3973
Patient appointments: 800-789-7366