Selected Publications
Joseph TT, Bu W, Haji-Ghassemi O, Chen YS, Woll K, Allen PD, Brannigan G, van Petegem F, Eckenhoff R.: Propofol directly binds and inhibits skeletal muscle ryanodine receptor 1 (RyR1) British Journal of Anaesthesia : 2024.
Johanna Becker-Baldus, Alexei Yeliseev, Thomas T. Joseph, Snorri Th. Sigurdsson, Lioudmila Zoubak, Kirk Hines, Malliga R. Iyer, Arjen van den Berg, Sam Stepnowski, Jon Zmuda, Klaus Gawrisch, and Clemens Glaubitz: Probing the Conformational Space of the Cannabinoid Receptor 2 and a Systematic Investigation of DNP-Enhanced MAS NMR Spectroscopy of Proteins in Detergent Micelles ACS Omega 8(36) : 32963-32976,2023.
John T Petroff, Noah M Dietzen, Ezry Santiago-McRae, Brett Deng, Maya S Washington, Lawrence J Chen, K Trent Moreland, Zengqin Deng, Michael Rau, James AJ Fitzpatrick, Peng Yuan, Thomas T Joseph, Jérôme Hénin, Grace Brannigan, Wayland WL Cheng: Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation Nature Communications 13 (1): 7017,2022.
Joseph TT: Best practices for resilient automation of biomolecular simulations Methods in Cell Biology 169 : 2022.
Joseph TT, Bu W, Lin W, Zoubak L, Yeliseev A, Liu R, Eckenhoff RG, Brannigan G: Ketamine Metabolite (2R,6R)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors ACS Chem Neurosci 12 (9): 1487–1497,2021.
Yeliseev A, Iyer MR, Joseph TT, Coffey NJ, Cinar R, Zoubak L, Kunos G, Gawrisch K: Cholesterol as a modulator of cannabinoid receptor CB2 signaling Scientific Reports 11 (Article number: 3706): 2021.
Wague A, Joseph TT, Woll KA, Bu W, Vaidya KA, Bhanu NV, Garcia B, Nimigean CM, Eckenhoff RG, Riegelhaupt PM: Mechanistic insights into volatile anesthetic modulation of K2P channels eLife 9 : e59839,2020.
Wenric S, Jeff JM, Joseph T, Yee M-C, Belbin GM, Owusu Obeng A, Ellis SB, Bottinger EP, Gottesman O, Levin MA, Kenny EE: Rapid response to the alpha-1 adrenergic agent phenylephrine in the perioperative period is impacted by genomics and ancestry Pharmacogenomics Journal 21 : 174–189,2020.
Thomas T Joseph, David B Wax, Raymond Goldstein, Jia Huang, Patrick J McCormick, Matthew A Levin: A Web-Based Perioperative Dashboard as a Platform for Anesthesia Informatics Innovation Anesthesia and Analgesia 131 (5): 1640-1645,2020.
McKinstry-Wu Andrew, Woll Kellie A, Joseph Thomas, Bu Weiming, White E Railey, Bhanu Natarajan V, Garcia Benjamin A, Brannigan Grace, Dailey William P, Eckenhoff Roderic G: Azi-medetomidine: Synthesis and Characterization of a Novel α2 Adrenergic Photoaffinity Ligand. ACS Chemical Neuroscience 10 (11): 4716-4728,2019.
Salari R, Joseph T, Lohia R, Hénin J, Brannigan G: A streamlined, general approach for computing ligand binding free energies and its application to GPCR-bound cholesterol Journal of Chemical Theory and Computation 14 (12): 6560–6573,2018.
Kass JL, Lakha S, Levin MA, Joseph T, Lin H-M, Genden EM, Teng MS, Miles BA, DeMaria S: Intraoperative hypotension and flap loss in free tissue transfer surgery of the head and neck Head and Neck 40 (11): 2315-2557,2018.
Flaherty D, Kim S, Zerillo J, Park C, Joseph T, Hill B, Lin H-M, Li J, Hamsher C, Weiner MM, DeMaria S: Preoperative QTc Interval is Not Associated With Intraoperative Cardiac Events or Mortality in Liver Transplantation Patients. Journal of Cardiothoracic and Vascular Anesthesia : pii: S1053-0770(18)30389-6,2018.
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Academic Contact Information
Department of Anesthesiology and Critical Care
John Morgan Building, 319A
3620 Hamilton Walk
Philadelphia,
PA
19104