Description of Research Expertise
Dr. Aleman has extensive expertise in the study of hereditary retinal degenerations. He is part of the Retinal Degeneration Center at Scheie Eye Institute and the CAROT center of the Department of Ophthalmology of the University of Pennsylvania. His research expertise includes state-of-the-art psychophysical, electrophysiological and imaging studies in patients and animal models of the human disease. Most of the studies in which Dr. Aleman is an investigator are aimed to lead patients with these incurable retinal degenerations into clinical trials as well as in the detailed characterization of patients, both children and adults, with these conditions.
Clinical Trials
Dr. Aleman is a co-principal investigator in an ongoing gene therapy trial for choroideremia.
Key Words
Hereditary Retinal Degenerations, retinitis pigmentosa, choroideremia, cone rod dystrophy, optical coherence tomography, electroretinogram
Selected Publications
Pierce EA, Aleman TS, Jayasundera KT, Ashimatey BS, Kim K, Rashid A, Jaskolka MC, Myers RL, Lam BL, Bailey ST, Comander JI, Lauer AK, Maguire AM, Pennesi ME.: Gene Editing for CEP290-Associated Retinal Degeneration N Engl J Med : 2024.
Wynne N, Jiang YY, Aleman TS, Morgan JIW.: FOVEAL PHENOTYPES IN CHOROIDEREMIA ON ADAPTIVE OPTICS SCANNING LIGHT OPHTHALMOSCOPY Retina 44 : 659-668,2024.
Wu V, Swider M, Sumaroka A, Dufour VL, Vance JE, Aleman TS, Aguirre GD, Beltran WA, Cideciyan AV.: Retinal response to light exposure in BEST1-mutant dogs evaluated with ultra-high resolution OCT Vision Research : 2024.
Aung MH, Aleman TS, Garcia AS, McGeehan B, Ying GS, Avery RA.: Stimulus type and duration affect magnitude and evolution of flicker-induced hyperemia measured by laser speckle flowgraphy at the optic disc and peripapillary vessels Sci Rep 14 : 6659,2024.
Lam BL, Pennesi ME, Kay CN, Panda S, Gow JA, Zhao G, MacLaren RE; XIRIUS Study Group.: Assessment of Visual Function with Cotoretigene Toliparvovec in X-Linked Retinitis Pigmentosa in the Randomized XIRIUS Phase 2/3 Study Ophthalmology : 2024.
Kim B, Daniel E, Aleman TS, Cousins KAQ, Iacobucci E, Yu Y, Ying G-S, Irwin D: Choroidal evaluation of FTLD-Tau and biomarker-determined Alzheimer’s Disease. Invest. Ophthalmol. Vis. Sci. Invest. Ophthalmol. Vis. Sci. : 1375,2024.
Bedoukian E, Bennett J, Uyhazi KE, Maguire AM, O'Neil E, Krauss E, Roman AJ, Sumaroka A, Swider M, Scoles D, Garafalo AV, Cideciyan AV, Aleman TS: Treatment potential of RPGRIP1-associated inherited retinal degenerations Invest. Ophthalmol. Vis. Sci. : 2209,2024.
Cideciyan AV, Li RTH, Roman AJ, Sumaroka A, Stanton CM, Swider M, Garafalo AV, Heon E, Vincent A, Wright AF, Megaw R, Aleman TS, Browning AC, Dhillon B: Early-onset sub-RPE deposits in late-onset retinal degeneration (L-ORD)caused by the c.489C>G (p.S163R) founder variant in C1QTNF5 Invest. Ophthalmol. Vis. Sci. : 1385,2024.
Wynne N, Jiang Y, Aleman TS, Morgan JIW: Retinal sensitivity in comparison to cone density in choroideremia Invest. Ophthalmol. Vis. Sci. : 4946,2024.
1. Aleman TS, Cideciyan AV, Weber ML, Santos A, Uyhazi KE, Parchinski K, Chung W, Margaritis P, Sun J, Scoles D, Garafalo AV, Jayagopal A, Yerxa BR, Tuller S, Maguire AM, Bennett J: AAV8-hLCA5 subretinal delivery to the macula in LCA5-associated Leber Congenital Amaurosis (LCA5-LCA): Preliminary safety and efficacy results of an ongoing phase I/II gene therapy trial Invest. Ophthalmol. Vis. Sci. : 3288,2024.
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Academic Contact Information
Scheie Eye Institute
51 North 39th Street
Philadelphia,
PA
19104
Phone: 215-614-4100
Patient appointments: 800-789-7366