Description of Research Expertise

Cell and Molecular Biology
Spine
Intervertebral Disc

Selected Publications

Tian Z, Chen K, Shofer FS, Ciesielski B, Wang H, O'Brien WT, Qin L, Zhang Y.: Gene Expression Changes Precede Elevated Mechanical Sensitivity in the Mouse Intervertebral Disc Injury Model. JOR Spine 8 (1): 2025.

Jiawei Lu, Zuozhen Tian, Frances S Shofer, Ling Qin, Honghong Sun, Yejia Zhang: Tnfaip8 and Tipe2 Gene Deletion Ameliorates Immediate Proteoglycan Loss and Inflammatory Responses in the Injured Mouse Intervertebral Disc Am J Phys Med Rehabil 103 (10): 918-924,2024.

Chen K, Tian Z, Wang H, Qin L, Enomoto-Iwamoto M, Zhang Y.: Gene Expression Profiles Perturbed by Injury to the Mouse Intervertebral Disc Am J Phys Med Rehabil : 2024.

Li J, Gui T, Yao L, Guo H, Lin YL, Lu J, Duffy M, Zgonis M, Mauck R, Dyment N, Zhang Y, Scanzello C, Seale P, Qin L.: Synovium and infrapatellar fat pad share common mesenchymal progenitors and undergo coordinated changes in osteoarthritis J Bone Miner Res 39 : 161-176,2024.

Chen K, Tian Z, Wang H, Enomoto-Iwamoto M, Zhang Y: ADAM8 Inactivation Modulates Cellular Component Assembly Gene Expression in the Mouse Intervertebral Disc Genes & Diseases : 2024.

Lu J, Tian Z, Shofer FS, Yao L, Sandroni AZ, Sun H, Qin L, Zhang Y.: Tnfa , Il6 , Cxcl1 , and Adam8 Genes Are the Early Markers After Mouse Tail Intervertebral Disc Injury Am J Phys Med Rehabil 102 : 1063-1069,2023.

Tian Z, Shofer FS, Fan M, Sandroni AZ, Yao L, Han L, Qin L, Enomoto-Iwamoto M, Zhang Y.: ADAM8 inactivation retards intervertebral disc degeneration in mice Genes Diseases 11 : 101059,2023.

Lu K, Wang Q, Jiang H, Li J, Yao Z, Huang Y, Chen J, Zhang Y, Xiao G, Hu X, Luo Z, Yang L, Tong L, Chen D.: Upregulation of β-catenin signaling represents a single common pathway leading to the various phenotypes of spinal degeneration and pain Bone Res 11 : 18,2023.

Tian Z, Shofer FS, Sandroni AZ, Zhao L, Scanzello CR, Zhang Y.: Expression of Human Interleukin 8 in Mice Alters Their Natural Behaviors J Inflamm Res 15 : 2413-2424,2022.

Song N, Xie P, Shen W, Oh H, Zhang Y, Vitale F, Javanmard M, Allen MG.: A microwell-based impedance sensor on an insertable microneedle for real-time in vivo cytokine detection Microsyst Nanoeng 7 : 96,2021.

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Academic Contact Information

Penn Medicine at Rittenhouse
1800 Lombard Street/1st Floor
Philadelphia, PA 19146
Phone: 215-893-2645