Selected Publications
Nannan Li, Jesse L. Rodriguez, Yibo Yin, Meghan T Logun, Logan Zhang, Shengkun Yu, Kelly A. Hicks, Vicky Zhang, Laura Zhang, Chuncheng Xie, Jiabin Wang, Joseph A Fraietta, Zev A. Binder*, Zhiguo Lin*, and Donald M. O’Rourke*: Armored Bicistronic CAR T Cells with Dominant-negative TGF-β Receptor II to Overcome Resistance in Glioblastoma Mol Ther 32 (10): 3522-3538,2024.
Elinor Willis, Jillian Verrelle, Esha Banerjee, Charles-Antoine Assenmacher, James C. Tarrant, Nicholas Skuli, Moriah L. Jacobson, Donald M. O’Rouke, Zev A. Binder*, and Enrico Radaelli1*: Humanization with CD34-positive hematopoietic stem cells in NOG-EXL mice results in improved long-term survival and less severe myeloid cell hyperactivation phenotype relative to NSG-SGM3 mice Veterinary Pathology 61 (4): 664-674,2024.
Jingxian Liu, Song Cao, Kathleen J. Imbach, Marina A. Gritsenko, Tung-Shing M. Lih, Jennifer E. Kyle*, Tomer M. Yaron*, Zev A. Binder*, Yize Li*, Ilya Strunilin*, Yi-Ting Wang*, Chia-Feng Tsai*, Weiping Ma*, Lijun Chen*, Natalie M. Clark, Andrew Shinkle, Nataly Naser Al Deen, Wagma Caravan, Andrew Houston, Faria A. Simin, Matthew A. Wyczalkowski, Liang-Bo Wang, Erik, Storrs, Siqi Chen, Ritvik Illindala, Yuping D. Li, Reyka G. Jayasinghe, Dmitry Rykunov, Sandra L. Cottingham, Rosalie K. Chu, Karl K. Weitz, Ronald J. Moore, Tyler Sagendorf, Vladislav A. Petyuk, Michael Nestor, Lisa M. Bramer, Kelly G. Stratton, Athena A. Schepmoes, Sneha P. Couvillion, Josie Eder, Young-Mo Kim, Yuqian Gao, Thomas L. Fillmore, Rui Zhao, Matthew E. Monroe, Austin N. Southard-Smith, Yang E. Li, Rita Jui-Hsien Lu, Jared L. Johnson, Maciej Wiznerowicz, Galen Hostetter, Chelsea J. Newton, Karen A. Ketchum, Ratna R. Thangudu, Jill S. Barnholtz-Sloan, Pei Wang, David Fenyö, Eunkyung An, Mathangi Thiagarajan, Ana I. Robles, D. R. Mani, Richard D. Smith, Eduard Porta-Pardo, Lewis C. Cantley, Antonio Iavarone, Feng, Chen, Mehdi Mesri, MacLean P. Nasrallah, Hui Zhang, Adam C. Resnick, Milan G. Chheda, Karin D. Rodland, Tao Liu, Li Ding, Philadelphia Coalition for a Cure, Clinical Proteomic Tumor Analysis Consortium: Multi-scale signaling and tumor evolution in high-grade gliomas Cancer Cell 42 (7): 1217-1238.e19,2024.
Stephen J. Bagley, Meghan Logun, Joseph A. Fraietta, Xin Wang, Arati S. Desai, Linda J. Bagley, Danuta Jarocha, Rene Martins, Eileen Maloney, Lester Lledo, Carly Stein, Amy Marshall, Rachel Leskowitz, Julie K. Jadlowsky, Shannon Christensen, Bike Su Oner, Gabriela Plesa, Andrea Brennan, Vanessa Gonzalez, Fang Chen, Yusha Sun, Whitney Gladney, David Barrett, Ali Nabavizadeh, MacLean P. Nasrallah, Wei-Ting Hwang, Guo-Li Ming, Hongjun Song, Donald L. Siegel, Carl H. June, Elizabeth O. Hexner, Zev A. Binder*, Donald M. O'Rourke*: Intrathecal Bivalent CAR T Cells Targeting EGFR and IL13Rα2 in Recurrent Glioblastoma: Phase 1 Trial Interim Results Nat Med 30 (5): 1320-1329,2024.
David E. Reynolds, Yusha Sun, Xin Wang, Phoebe Vallapureddy, Jianhua Lim, Menghan Pan, Andres Fernandez Del Castillo, Jonathan C. T. Carlson, Mark A. Sellmyer, Maclean Nasrallah, Zev Binder, Donald M. O’Rourke, Guo-li Ming, Hongjun Song, and Jina Ko: Live Organoid Cyclic Imaging Adv Sci (Weinh) 11 (14): e2309289,2024.
Stephen J. Bagley*, Zev A. Binder*, Lamia Lamrani*, Eliana Marinari, Arati S. Desai, MacLean P. Nasrallah, Eileen Maloney, Steven Brem, Robert A. Lustig, Goldie Kurtz, Michelle Alonso-Basanta, Pierre-Emmanuel Bonté, Christel Goudot, Wilfrid Richer, Eliane Piaggio, Shawn Kothari, Lea Guyonnet, Coralie L. Guerin, Joshua J. Waterfall, Suyash Mohan, Wei-Ting Hwang, Oliver Y. Tang, Meghan Logun, Meghna Bhattacharyya, Kelly Markowitz, Devora Delman, Amy Marshall, E. John Wherry, Sebastian Amigorena, Gregory L. Beatty, Jennifer L. Brogdon, Elizabeth Hexner, Denis Migliorini, Cecile Alanio & Donald M. O’Rourke: Repeated peripheral infusions of anti-EGFRvIII CAR T cells in combination with pembrolizumab show no efficacy in glioblastoma: a phase 1 trial Nature Cancer 5 (3): 517-531,2024.
Jun Guo, Anahita Fathi Kazerooni, Erik Toorens, Hamed Akbari, Fanyang Yu, Chiharu Sako, Elizabeth Mamourian, Russell T. Shinohara, Constantinos Koumenis, Stephen J. Bagley, Jennifer J. D. Morrissette, Zev A. Binder, Steven Brem, Suyash Mohan, Robert A. Lustig, Donald M. O’Rourke, Tapan Ganguly, Spyridon Bakas, MacLean P. Nasrallah & Christos Davatzikos: Integrating imaging and genomic data for the discovery of distinct glioblastoma subtypes: a joint learning approach Sci Rep 14 (1): 4922,2024.
Fanyang Yu, Jun Guo, Anahita Fathi Kazerooni, Hamed Akbari, Erik Toorens, Chiharu Sako, Elizabeth Mamourian, Stephen J Bagley, Zev Binder, Robert A Lustig, Steven Brem, Donald M O'Rourke, Tapan Ganguly, Spyridon Bakas, MacLean P Nasrallah, Pratik Chaudhari, Christos Davatzikos: NIMG-66. Radiogenomics-Based Heterogeneity Analysis of Glioblastoma Reveals MR Imaging Phenotypical Characterization of EGFR Mutations Neuro-Oncology 25 (Supplement_5): 2023.
Nannan Li, Jesse Rodriguez, Zev Binder, Donald O’Rourke: Dual antigen targeting CAR T cells armored with a dominant-negative TGF-β Receptor II enhance antitumor potency by overcoming TGF-β immunosuppression in GBM. Journal for ImmunoTherapy of Cancer : 2023.
Meghan Logun, Stephen J Bagley, Xin Wang, Daniel Zhang, Yusha Sun, Guo-li Ming, Ali Nabavizadeh, Amy Marshall, Eileen Maloney, Wei-Ting Hwang, Joseph Fraietta, Vanessa Gonzalez, Arati Desai, Linda Bagley, Elizabeth Hexner, MacLean P Nasrallah, Hongjun Song, Zev Binder, Donald M O'Rourke: CTIM-40. Early Radiographic Response and Engraftment of Phase I First-in-Human Bicistronic CAR T Cells Correlate with Real-Time Autologous GBM Organoid Cytolysis Neuro-Oncology 25 (Supplement_5): 2023.
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