Selected Publications
McAfee Q, Chen CY, Yang Y, Caporizzo MA, Morley M, Babu A, Jeong S, Brandimarto J, Bedi KC Jr, Flam E, Cesare J, Cappola TP, Margulies K, Prosser B, Arany Z.: Truncated titin proteins in dilated cardiomyopathy Sci Transl Med 13 : eabd7287,2021.
Goli, Rahul, Li, Jian, Brandimarto, Jeff, Levine, Lisa D, Riis, Valerie, McAfee, Quentin, DePalma, Steven, Haghighi, Alireza, Seidman, J G, Seidman, Christine E, Jacoby, Daniel, Macones, George, Judge, Daniel P, Rana, Sarosh, Margulies, Kenneth B, Cappola, Thomas P, Alharethi, Rami, Damp, Julie, Hsich, Eileen, Elkayam, Uri, Sheppard, Richard, Alexis, Jeffrey D, Boehmer, John, Kamiya, Chizuko, Gustafsson, Finn, Damm, Peter, Ersboll, Anne S, Goland, Sorel, Hilfiker-Kleiner, Denise, McNamara, Dennis M, IMAC-2 and IPAC Investigators, Arany, Zolt: Genetic and Phenotypic Landscape of Peripartum Cardiomyopathy. Circulation : 2021.
Murashige D, Jang C, Neinast M, Edwards JJ, Cowan A, Hyman MC, Rabinowitz JD, Frankel DS, Arany Z.: Comprehensive quantification of fuel use by the failing and nonfailing human heart Science 370 : 364-368,2020.
Ibrahim A, Yucel N, Kim B, Arany Z: Local Mitochondrial ATP Production Regulates Endothelial Fatty Acid Uptake and Transport Cell Metabolism 4 (32): 309-319,2020.
Hoshino Atsushi, Wang Wei-Jia, Wada Shogo, McDermott-Roe Chris, Evans Chantell S, Gosis Bridget, Morley Michael P, Rathi Komal S, Li Jian, Li Kristina, Yang Steven, McManus Meagan J, Bowman Caitlyn, Potluri Prasanth, Levin Michael, Damrauer Scott, Wallace Douglas C, Holzbaur Erika L F, Arany Zoltan: The ADP/ATP translocase drives mitophagy independent of nucleotide exchange. Nature 575 (7782): 375-379,2019.
Neinast Michael D, Jang Cholsoon, Hui Sheng, Murashige Danielle S, Chu Qingwei, Morscher Raphael J, Li Xiaoxuan, Zhan Le, White Eileen, Anthony Tracy G, Rabinowitz Joshua D, Arany Zoltan: Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids. Cell metabolism 29 (2): 417-429.e4,2018.
Kim Boa, Jang Cholsoon, Dharaneeswaran Harita, Li Jian, Bhide Mohit, Yang Steven, Li Kristina, Arany Zolt: Endothelial pyruvate kinase M2 maintains vascular integrity. The Journal of clinical investigation 128 (10): 4543-4556,2018.
Das Abhirup, Huang George X, Bonkowski Michael S, Longchamp Alban, Li Catherine, Schultz Michael B, Kim Lynn-Jee, Osborne Brenna, Joshi Sanket, Lu Yuancheng, Treviño-Villarreal Jose Humberto, Kang Myung-Jin, Hung Tzong-Tyng, Lee Brendan, Williams Eric O, Igarashi Masaki, Mitchell James R, Wu Lindsay E, Turner Nigel, Arany Zolt, Guarente Leonard, Sinclair David A: Impairment of an Endothelial NAD-HS Signaling Network Is a Reversible Cause of Vascular Aging. Cell 173 (1): 74-89.e20,2018.
Ware JS, Li J, Mazaika E, Yasso CM, DeSouza T, Cappola TP, Tsai EJ, Hilfiker-Kleiner D, Kamiya CA, Mazzarotto F, Cook SA, Halder I, Prasad SK, Pisarcik J, Hanley-Yanez K, Alharethi R, Damp J, Hsich E, Elkayam U, Sheppard R, Kealey A, Alexis J, Ramani G, Safirstein J, Boehmer J, Pauly DF, Wittstein IS, Thohan V, Zucker MJ, Liu P, Gorcsan J, McNamara DM, Seidman CE, Seidman JG, Arany Z: Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies. The New England journal of medicine 374 (3): 233-41,2016.
Jang C, Oh SF, Wada S, Rowe GC, Liu L, Chan MC, Rhee J, Hoshino A, Kim B, Ibrahim A, Baca LG, Kim E, Ghosh CC, Parikh SM, Jiang A, Chu Q, Forman DE, Lecker SH, Krishnaiah S, Rabinowitz JD, Weljie AM, Baur JA, Kasper DL, Arany Z: A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance. Nature medicine 22 (4): 421-6,2016.
Patten IS, Rana S, Shahul S, Rowe GC, Jang C, Liu L, Hacker MR, Rhee JS, Mitchell J, Mahmood, Hess P, Farrell C, Koulisis N, Khankin EV, Burke SD, Tudorache I, Bauersachs J, del Monte F, Hilfiker-Kleiner D, Karumanchi SA, Arany Z: Cardiac angiogenic imbalance leads to peripartum cardiomyopathy. Nature 485 (7398): 333-8,2012.
Arany Z, Foo S-Y, Ma Y, Ruas JL, Bommi-Reddy A, Girnun G, Cooper M, Laznik D, Chinsomboon J, Rangwala SM, Baek KH, Rosenzweig A, Spiegelman BM: HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature 451 (7181): 1008-12,2008.
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Academic Contact Information
Perelman School of Medicine
University of Pennsylvania
11th floor Smilow Translational Research Center
34th and Civic Center Blvd
Philadelphia,
PA
19014
Phone: 215-898-3482