In Summer 2023, Penn Trauma Journal Reports Offer a Diverse Perspective on Trauma Practice and the Patient Experience

July Trauma Reports graphic with ambulanceIn July 2023, Penn Trauma researchers offered an overview of surgical decision-making, technical and practical advances, and comparative inquiry that embraced the breadth of trauma surgery and medicine.

Early posttraumatic brain injury tranexamic acid prevents blood-brain barrier hyperpermeability and improves surrogates of neuroclinical recovery.

Surgeons from Penn Trauma and Neurosurgery hypothesized that administration of the antifibrinolytic TXA early (1 hour post-TBI), blunts penumbral, blood-brain barrier (BBB) leukocyte-endothelial cell (LEU-EC) interactions and microvascular permeability, in vivo when compared with late administration (24 hours post-TBI).

July 2023. Journal of Trauma and Acute Care Surgery.

Operative and Nonoperative Outcomes of Emergency General Surgery Conditions: An Observational Study Using a Novel Instrumental Variable. Annals of Surgery 2023;278:72-78.

Kaufman EJ, Keele LJ, Wirtalla CJ, Rosen CB, Roberts SE, Mavroudis CL, Reilly PM, Holena DN, McHugh MD, Small D, Kelz RR.

To enhance decision-making in emergency general surgery, Penn Trauma researchers conducted a large (507,677 patients) retrospective study to compare operative versus nonoperative management of emergency general surgery conditions (including colorectal, upper GI, and hepatopancreaticobiliary conditions) on short- and long-term outcomes using instrumental variable analysis to minimize selection bias.

New Research from Penn Trauma

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